Jacques F.A.P. Miller

Medawar Prize Laureate (1990)

The Medawar Prize - 1990

Jacques F.A.P. Miller was awarded the Medawar Prize in 1990 for his work on the immunological function of the thymus and of the thymus-derived lymphocytes.

Highlighted Articles

QnAs with Max D. Cooper and Jacques F. A. P. Miller

Brian Doctrow
PNAS January 7, 2020 117 (1) 12-14; first published December 2, 2019; https://doi.org/10.1073/pnas.1920087116
Anyone who has ever contracted chicken pox can thank the adaptive immune system for future protection against the disease. It is also thanks to this system that vaccines prevent diseases. The adaptive immune system provides organisms with a memory of past infections, enabling the body to quickly kill returning infections before they can do significant damage. Immunologists Jacques F. A. P. Miller and Max D. Cooper determined that adaptive immunity requires 2 distinct cell types that perform complementary functions.

Discovering the Origins of Immunological Competence

Jacques F. A. P. Miller
Annual Review of Immunology Vol. 17:1-17 (Volume publication date April 1999) https://doi.org/10.1146/annurev.immunol.17.1.1
Work done in the late 1950s and in the 1960s revealed the role of the thymus in virus-induced leukemia in mice. Thymectomizing mice at birth to test whether the virus first multiplied in thymus tissue and then spread elsewhere ultimately led to the conclusion that the thymus was essential to the normal development of the immune system. Subsequent testing to try to understand how the thymus contributes to the pool of immunocompetent lymphocytes opened a new chapter in immunology and required a reappraisal of many immunological phenomena and an understanding of the molecular interactions that take place during cell-to-cell interactions.

Highlighted Videos

B and T cells — The Organizing Principle of the Adaptive Immune System

Albert and Mary Lasker Foundation, September 9, 2019

Professor Jacques Miller: T cells and the Immune System

WEHImovies, July 12, 2017

Jacques Miller 50th Anniversary

WEHImovies, December 1, 2016



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