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Participate in the DICG public consultation concerning the Declaration of Istanbul

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To celebrate the 10th anniversary of the DoI, which was created in 2008, a draft new edition of the DoI has been prepared by a multidisciplinary working group with 39 members. The group has reviewed the original DoI in the light of persisting and emerging issues relating to organ trafficking and transplant tourism, and made changes which are intended to ensure that the DoI offers clear guidance for health professionals and policy makers.

Click here to view the draft DOI and provide your feedback

Paul Teraski honored by the national inventors hall of fame

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The Class of 2018 will be honored at "The Greatest Celebration of American Innovation," a two-day event held in Washington D.C.. In partnership with the United States Patent and Trademark Office (USPTO), NIHF will honor these Inductees May 2-3 at one of the innovation industry's most highly anticipated events — "The Greatest Celebration of American Innovation."

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Transplantation Journal - Featured Article

Submitted by Dr Andrea Schlegel, Editorial Fellow, Transplantation.

A Comparison of HLA Molecular Mismatch Methods to Determine HLA Immunogenicity [published online February 13, 2018]

Wiebe C, Kosmoliaptsis V, Pochinco D, Taylor C, Nickerson P..
Transplantation. doi: 10.1097/TP.0000000000002117.

The authors present the first comparison of available scoring systems to assess HLA donor-recipient mismatches and their correlation with the development of de novo donor-specific antibody (dnDSA) in kidney transplant recipients on active immunosuppression. The authors determined HLA-DR and DQ molecular mismatches at the molecular level comparing 3 different methods: an eplet analysis that identifies small patches of surface exposed mismatched amino acids, an amino acid mismatch scoring physicochemical properties of all mismatched amino acid sequence polymorphisms, and an electrostatic mismatch that assesses the HLA tertiary structure for unique electrostatic potential profiles. The authors tested those methods in 596 renal transplant recipients and correlated their results with the development of HLA-DR/DQ dnDSA´s. Authors demonstrate a good correlation among the 3 scoring systems (R2=0.85-0.96). Importantly, HLA-DR and DQ free survival after kidney transplantation equally correlated with Eplet, amino acid and electrostatic mismatches (p<0.0001). Notably, all 3 methods predicted the development of dnDSA in a multivariate analysis after adjustment for recipient age, immunosuppression, and nonadherence, thus providing precise methods of alloimmune risk assessment.

CLICK HERE TO VIEW

TTS-IRTA WEBINAR WEDNESDAY, MARCH 14, 2018 - 12 Noon EST (Montreal Time)

Click HERE FOR MORE INFORMATION AND TO SIGNUP

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UPDATE OF THE INTERNATIONAL INTESTINAL TRANSPLANT REGISTRY AND INTESTINAL TRANSPLANT OUTCOMES

Speaker: Matthew Everly, PharmD, BCPS, FAST, Director, Terasaki Research Institute, Los Angeles, CA, USA


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Moderator: Robert Venick, MD
, Associate Professor of Pediatrics and Surgery; Medical Director, Intestinal Transplantation David Geffen School of Medicine, UCLA, Los Angeles, CA USA

 


In the News

Pakistan - SIUT’s transplant operating theatre complex opened

March 3 - The Sindh Institute of Urology and Transplantation (SIUT) on Friday opened its state-of-the-art Bashir Dawood Transplant Operating The­atre Complex equipped to carry out up to four transplant surgeries simultaneously.

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Johns Hopkins doctors successfully transplant hepatitis C-infected kidneys into virus-free patients

March 6 - In a small study, doctors at Johns Hopkins have successfully transplanted 10 hepatitis C-infected kidneys into patients without hepatitis C and prevented the patients from becoming infected by hepatitis C. The success of these transplants could mean more organs being available for the nearly 100,000 people in the U.S. currently waiting for a kidney transplant.

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Scientists Identify "Elusive" Human Pancreatic Progenitor Cells

February 28 - Scientists at the Diabetes Research Institute (DRI), University of Miami, have identified and characterized a population of progenitor cells located in defined areas of the human pancreas, which can be stimulated to develop into glucose-responsive beta cells.

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First Liver Transplant Surgery Performed in Patient With CRC Metastases

February 28 - To improve patient outcomes, physicianresearchers in Cleveland Clinic’s Liver Cancer Program have developed a new transplantation protocol for treating liver metastases from CRC.

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New Stem Cell Found in Lung, May Offer Target for Regenerative Medicine

March 1 - Newly identified stem cells in the lung that multiply rapidly after a pulmonary injury may offer an opportunity for innovative future treatments that harness the body's ability to regenerate.

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22-year-old's 3-D scanner can diagnose heart diseases in 90 seconds

March 8 - The company built a 3-D heart scanner that it hopes will change how ERs treat chest pain

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Researchers move one step closer towards functioning kidney tissue from stem cells

March 2 - Researchers from the Murdoch Children's Research Institute (MCRI), University of Melbourne and Leiden University Medical Centre (LUMC) in The Netherlands have made an important step towards making human kidneys from stem cells that they one day hope can be used to treat kidney disease.

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Drug saves lives of those on liver transplant list, in world-first treatment

March 3 - In a world-first, Melbourne's Austin Health has reapplied how the drug Terlipressin is given to patients waiting for a liver transplant, reducing the length of hospital stays and improving their post-surgery recovery.

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Study to look at extending heart transplantation donor pool

March 6 - Surgeons and scientists at Baylor College of Medicine and the Texas Heart Institute will study the utility of previously unused organs to increase the number of heart transplantations, potentially making transplant possible for thousands of patients who die while waiting for an acceptable heart to become available.

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Scientists develop pigs for transplants

Mar. 8, 2018 - The Japan News -The Yomiuri Shimbun A team of scientists says it has created a pig that can be used in transplantations in humans. According to the team, which includes researchers from Meiji University and Kyoto Prefectural University, the animal is the first to be developed for transplantation based on national guidelines ..

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NIH Blog: Snapshots of Life: Finding Where HIV Hides

Researchers have learned a tremendous amount about how the human immunodeficiency virus (HIV), which causes AIDS, infects immune cells. Much of that information comes from studying immune cells in the bloodstream of HIV-positive people. Less detailed is the picture of how HIV interacts with immune cells inside the lymph nodes, where the virus can hide. In this image of lymph tissue taken from the neck of a person with uncontrolled HIV infection, you can see areas where HIV is replicating (red) amid a sea of immune cells (blue dots). Areas of greatest HIV replication are associated with a high density of a subtype of human CD4 T-cells (yellow circles) that have been found to be especially susceptible to HIV infection.

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Official Sections of The Transplantation Society

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