Freezing And Storing Donated Organs Could Eliminate Some Transplant Waitlists - Hype or Hope?
A news article appeared this week in the online news site futurism.com which highlighted the company Arigos and their goal of freezing and storing organs. The article was well balanced however we are looking for your feedback.
Is this Hype or Hope? What do you think about this technology and their chances for success in the absence of published research?
Short article commentary by TTS Member Christopher Burlak: The company, Arigos, has recently received attention for their claim of freezing organs as a solution the human organ shortage. While this technology would be an advancement enhancing coordination of life saving organs as they are delivered to the patient, the company founders haven't published any of their science. They propose that as helium inflates organs for freezing it protects the vasculature and cellular structure from ice crystal damage. Functional data will be imperative to understand if their organs are worth pursing as a tool to better prepare a patient and organ for transplantation. The science has the potential to dramatically reduce the cost of using genetically engineered large animals as well. We could have pigs raised to different maturities and thus organ sizes and then procured and preserved by this method. Then there would be no housing or standing costs for pig herds. The reduced environmental impact and herd loss due to age would be a real incentive. Ultimately the balance of business and science are necessary for their mutual success but science is driven by peer review and until that can happen there is little we can conclude about the importance of Arigos and their technology.
Transplantation Direct Journal - Highlighted Article
Submitted by Dr Joel Thomas Adler, Editorial Fellow, Transplantation.
Center-driven and Clinically Driven Variation in US Liver Transplant Maintenance Immunosuppression Therapy: A National Practice Patterns Analysis.
Nazzal M, Lentine KL, Naik AS, et al.
Transplant Direct. 2018;4:e364
There is little known about immunosuppression variation after liver transplantation. Using a unique database that integrates the United States national transplant registry and pharmacy fill records, the authors were able to study the immunosuppression regimens of nearly 25 000 liver transplant recipients. The most common regimen was triple immunosuppression for the first 6 months; this changed to either a corticosteroid or antimetabolite sparing regimen from 7-12 months. Clinical characteristics explained little of the variation; rather, it seemed driven by individual program immunosuppression regimens. These data provide insight into how liver immunosuppression is chosen, but perhaps most importantly, this analysis creates a framework to study comparative effectiveness in a natural experiment.
Prof. Haberal Receives Honorary Fellowship of the International Medical Sciences Academy
Caption: Prof. Haberal addresses the membership during his lecture on "Experimental and Clinical Application of Ileobladder Technique in Kidney Transplantation for Very Small and/or Neurogenic Bladder
On 24-25 August, 2018, Prof. Mehmet Haberal, President of The Transplantation Society, was invited as guest of honor to the 37th Congress of the International Medical Sciences Academy (IMSA) in Glasgow, Scotland.
The meeting was organized in the 400-year-old historic building that is home to the Royal College of Physicians and Surgeons of Glasgow in Scotland, UK. Prof. Nadey Hakim, Vice President of IMSA and Past World President of the International College of Surgeons introduced Prof. Haberal to the distinguished members as a pioneer in surgery and as founder of Başkent University, the first Foundation University in Turkey with a medical faculty and health services, which is celebrating its 25th year.
Clearing a Xenotransplantation Hurdle: Detecting Infectious Agents in Pigs
In a paper published in Xenotransplantation, Mark Prichard, PhD, and colleagues at the University of Alabama at Birmingham have described the development and testing of 30 quantitative assays for pig infectious agents. These assays had sensitivities similar to clinical lab assays for viral loads in human patients. After validation, the UAB team also used the assays on nine sows and 22 piglets delivered from the sows through caesarian section.
In the News
Niki Lauda: Former F1 champion 'functioning well' after lung transplant
August 6 - The 69-year-old had been suffering from "severe lung disease," according to the Vienna General Hospital, and had surgery on August 2 after flying home from a holiday in Ibiza.
USA - Kidney allocation system may improve access to kidney transplants
August 24 - The implementation of a kidney allocation system improved equity in access to kidney transplants; however, there were geographic disparities, according to results recently published.