The Transplantation Society is a non-profit NGO providing global leadership in transplantation. Our core mission include the development of the science and clinical practice, scientific communication, continuing education and guidance on the ethical practice.

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New! Transplantation - Vol. 102, No. 5, May 2018

Livers, kidneys and frail patients for lung transplantation provide some themes for your reading this month. A series of papers consider risk factors in liver transplantation. The ILTS consensus guideline for immunosuppression after liver transplantation provide important reading, and there is also news in xenotransplantation, kidney transplantation and management of PTLD and renal cell cancer.

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TTS EDUCATION COMMITTEE WEBINAR SERIES
"TRENDS AND CHALLENGES IN LIVER TRANSPLANTATION"

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TUESDAY, MAY 15, 2018 - 2:00 PM EDT (MONTREAL TIME)
KIDNEY PROBLEMS IN LIVER TRANSPLANTATION

sukru Moderator: Marcelo Cantarovich, MD
Professor, Department of Medicine, Division of Nephrology, Faculty of Medicine, McGill University
Montréal, QC, Canada
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Discussant: Annmarie Huysman Liapakis, MD
Assistant Professor of Medicine (Digestive Diseases), Yale School of Medicine
New Haven, CT, USA

  • Management of hepatorenal syndrome
  • Outcomes of hepatorenal syndrome, organ access
  • Indications for combined liver/kidney transplant
  • Learn how to optimize care of the cirrhotic patient to prevent hepatorenal syndrome
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Discussant: Clifford D. Miles, MD, MS, FAST
Associate Professor of Internal Medicine
University of Nebraska Medical Center
Omaha, NE, USA

  • Review the etiologies of kidney injury in the setting of liver disease
  • Discuss pathophysiology of hepatorenal syndrome
  • Know how to establish the diagnosis of hepatorenal syndrome

CLICK FOR DETAILS AND TO SIGNUP

STATEMENT ON THE GLOBAL KIDNEY EXCHANGE CONCEPT

CoE Statement on GKE

The Council of Europe’s Committee on Organ Transplantation has rejected a US-backed organ-swapping plan as “human organ trafficking” over concerns that donors will be abused. According to the committee, organ-swapping, as proposed by the Global Kidney Exchange (GKE), goes against the fundamental rule of organ donation – that “the human body and its parts shall not give rise to financial gain or comparable advantage.”

Rafael Matesanz, founder of the National Transplant Organisation (ONT) of Spain and TTS 2018 Plenary speaker commented that "GKE can be considered a disguised form of commercialization, which can be included into the trend of the rich countries to seek the easiest formula to satisfy their demands for transplant organs at the expense of the citizens of poor countries."

Link to Statement

Matesanz Rafael
Don't miss Rafael Matesanz's plenary talk @ TTS 2018 on Challenges to improving deceased organ donation - past, present and future!


Read more at www.tts2018.org

CALL FOR HOSTING FOR THE 16TH MEETING OF THE INTERNATIONAL SOCIETY FOR ORGAN DONATION AND PROCUREMENT (2021)

The International Society for Organ Donation and Procurement aims to foster, promote and develop all aspects of organ and tissue donation and procurement. The ultimate aim is to increase the supply of high quality organs and tissue to match patients' need and to promote countries increasing performance towards self-sufficiency and improved opportunity for transplantation.

Every two years, the ISODP Congress brings together clinicians and scientists from all parts of the world in the fields of organ procurement and donation.

The most recent Congress was hosted in Geneva, Switzerland from September 5-9, 2017. The Congress welcomed 429 participants from 28 countries.

Deadline for submissions: June 15, 2018 

CLICK HERE TO READ MORE



In the News

Study Explains How Newborn Mice Can Regrow Damaged Hearts

Newborn mice are able to repair damaged heart tissue better than animals injured just a few days later in their lives. What accounts for this regenerative capacity, and exactly when and why it disappears, have been unanswered questions. A report in Science Advances (May 2) posits that the extracellular matrix gets in the way of heart tissue renewal.

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NIH clinical trial to track outcomes of kidney transplantation from HIV-positive donors to HIV-positive recipients

The first large-scale clinical trial to study kidney transplantations between people with HIV has begun at clinical centers across the United States. The HOPE in Action Multicenter Kidney Study will determine the safety of this practice by evaluating kidney recipients for potential transplant-related and HIV-related complications following surgery. The study is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

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American Society of Transplantation: PATIENTS Act would limit access to transplantation

The American Society of Transplantation opposes the Dialysis Patient Access to Integrated-care, Empowerment, Nephrologists and Treatment Services Demonstration Act, also known as the PATIENTS Demonstration Act, saying it would limit patient access to transplantation. The group joins dialysis provider Dialysis Clinic Inc., the American Association of Kidney Patients and the Kidney Care Alliance, which note the act would limit patient choice and favors the country's two largest for-profit dialysis organizations.

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Transplanted Human Islets Grow Blood Vessels and Secrete Insulin to Treat Diabetic Mice

Researchers in Japan and the U.S. have developed a laboratory technique for generating vascularized pancreatic islet tissue that when transplanted into diabetic mice grows a system of mature blood vessels and secretes insulin to control the animals' blood sugar.

The team, led by Hideki Taniguchi, M.D., Ph.D., and colleagues at the Yokahama City University Graduate School of Medicine in Japan, developed a tissue engineering method, known as self-condensation cell culture, which can generate endothelialized 3D tissue oganoids from multiple types of cells and diverse tissue fragments derived from a variety of organs. They say results from in vivo studies in which bioengineered human and mouse islets were transplanted into diabetic mice indicate that the technology could be used to create vascularized, functional islet tissue transplants for treating type 1 diabetes in humans.

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Survey study for transplant surgeons

Dr. Nancy Ascher and Dr. Chris Freise from the University of California, San Francisco, invite you to participate in a short survey study (5 minutes) on kidney transplantation in women with breast cancer. A diagnosis of breast cancer in a patient awaiting kidney transplantation might affect candidacy for receiving a transplant. Understanding how transplant surgeons make decisions in these situations could improve management recommendations and inform future trials. All participants will have the option of receiving the survey results. We appreciate your time!

Link to Survey


Liver Cells Switch Identities to Grow New Tissue

May 2 - By studying a rare liver disease called Alagille syndrome, scientists from UC San Francisco and Cincinnati Children's Hospital Medical Center have discovered the mechanism behind an unusual form of tissue regeneration that may someday reduce the need for expensive and difficult-to-obtain organ transplants.

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Lung Transplants in Scleroderma Patients As Safe, Effective As in Other Lung Disease Patients, Study Shows

May 3 - Patients with scleroderma who undergo lung transplants have similar survival rates to patients who get lung transplants due to other diseases, according to a new study.

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A transplant of CRISPR-edited liver cells could replace lifelong injections for hemophilia B patients

May 3 - A Salk Institute team transplanted liver cells into mouse models of hemophilia B, finding that the treatment restored their ability to form blood clots for a year. The hope is that this one-and-done treatment could replace the frequent injections of clotting factors that are currently used to treat the inherited blood disorder.

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Almost 100,000 Canadians registered to donate organs after Humboldt Broncos crash

May 8 - The crash killed 16 team members and staff, including 21-year-old Logan Boulet of Lethbridge, who signed his organ donor card just weeks earlier and wound up saving six lives. The “Logan Boulet effect” has snowballed across the country, too. Nearly 100,000 Canadians have signed up to become organ donors since the April 6 crash.

READ THE FULL ARTICLE


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Transplantation Direct - May 2018 - Volume 4 - Issue 5

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This month in Transplantation Direct we feature a wide variety of topics in transplantation. For those interested in liver transplantation, performing transplants with a venovenous bypass is explored in a large single center Canadian study, and Duke surgeons present a case of complications associated with an accessory gallbladder. A Japanese group examines the safety of performing an adult living donor liver transplant in patients with portal vein thrombosis; other articles focus on the value of MRCP in diagnosing biliary anastomotic strictures, and on mechanisms involving endothelial cell dysfunction in the context of steatotic human livers. In heart transplantation, data supporting the feasibility of biomarker use for monitoring right heart pressures is introduced. For those interested in kidney transplantation, we have reports on modifiable factors associated with prolonged warm ischemia time, a modified Delphi Study in the UK related to optimizing listing for transplantation, and on the use of personalized patient evaluation protocols for making decisions on live donation. Lung transplant studies are also included in this issue, examining cyclophosphamide use for refractory acute cellular rejection, and an analysis of long-term outcomes in combined lung-liver transplants. We hope that you find this content useful and look forward to an article contribution from you soon.

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Sindh Institute Of Urology And Transplant's Biomedical Ethics Centre Joins WHO Regional Activities

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April 26 - The Centre of Biomedical Ethics and Culture (CBEC) of the Sindh Institute of Urology and Transplant (SIUT) was designated as a World Health Organisation (WHO) Collaborating Centre in Bioethics at a special ceremony held at the SIUT.

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Hospital first in UK to introduce pioneering liver transplant technology

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Professor Chris Watson and Andrew Butler with the new machine (Sally Wardle/PA).

May 2 - A hospital has become the first in the UK to bring state-of-the-art liver transplant technology into routine practice. Addenbrooke's Hospital in Cambridge will use machine perfusion, a process which can keep a liver "alive" outside the body for up to 24 hours by maintaining it at body temperature. The technology allows doctors to test how well a liver is functioning before transplant, boosting the chances the procedure will be a success. Addenbrooke's has become the only liver transplant centre in the UK to use the perfusion technique as part of its standard clinical practice.

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In the News

Transflammation: A New Frontier In Regenerative Medicine

May 1 - Cardiovascular regeneration focuses on repairing or replacing damaged or senescent cardiac and vascular tissue. This damage is largely caused by myocardial ischemia (poor perfusion of the heart causing dysfunction or loss of cardiac tissue), fibrosis (with the replacement of myocytes and vessels with non-functional scar tissue) each of which may lead to heart failure, impaired functional capacity and quality of life, serious arrhythmias, and death.

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Implantable islet cells come with their own oxygen supply

April 25 - Treating type-1 diabetes by transplanting islet cells becomes a trend but proven challenging. One impediment is that once the islets are transplanted, they will kick the bucket in the event that they don't get a sufficient supply of oxygen. Presently, scientists at MIT, working with an organization called Beta-O2 Technologies, have created and tried an implantable gadget that outfits islet cells with their own supply of oxygen, by means of a chamber that can be recharged like clockwork.

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Organ Donation System Set For Changes

April 28 - NPR's Scott Simon speaks to transplant surgeon Dr. Dorry Segev about why the current system of organ allocation can be a death sentence for some patients.

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THE HEART PRINTER

April 18 - THE IDEA:Bioprinting fully functioning human hearts to be used for transplants. Steven Morris, 53, started BioLife4D in 2016, bringing on board Jeffrey Morgan, the head of cardiothoracic transplantation at Baylor College of Medicine, as chief medical officer. Bioprinting a full-size human organ has never been done. But Morris and Morgan have devised a method they believe can work that involves extracting blood cells from a transplant candidate, reengineering them into heart cells, then 3D printing the heart cells layer by layer into a functioning organ—chambers, valves, and all.

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