tts2018program

The Transplantation Society is a non-profit NGO providing global leadership in transplantation. Our core mission include the development of the science and clinical practice, scientific communication, continuing education and guidance on the ethical practice.

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This Handheld Device Could Print New Skin Onto Burn Victims

2018 05 02 skin 3d

Researchers have long been looking for methods of creating artificial skin grafts, either from biological or synthetic materials. There are a number of such products on the market, but they have limitations: some are expensive, some can only be used temporarily, some take weeks to create from the patient’s own skin cells. The University of Toronto researchers developed a printer the size of a shoe box, weighing less than one kilogram (2.2 pounds). It dispenses strips of “bio ink” made of biological materials. These materials include collagen—the most abundant protein in the dermis, or middle layer of the skin—and fibrin, a protein needed for wound healing. The strips of artificial skin can be deposited directly on the injured area.

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These cells turn lung transplants deadly

Researchers have uncovered the precise cells that flow into and cause inflammation in newly transplanted lungs.

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Understanding immune system interplay to improve organ transplant success

A rare opportunity to analyse both blood and tissue samples from human transplant recipients has allowed immunology researchers at the Babraham Institute to pinpoint how an immunosuppressive drug works to prevent the production of antibodies against the transplanted tissue. This understanding, gained through working together with transplant research immunologists in Oxford, may lead to improved ways of identifying transplant recipients at risk of rejection and treating autoimmune disease.

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Baby Born in World's First In Utero Stem Cell Transplant Trial

May 25 - An in utero stem cell transplant for a critically ill second-trimester fetus has led to the birth of an apparently healthy infant. The newborn is the first patient enrolled in the world's first clinical trial using stem cells transplanted prior to birth.

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U.S. DRUG OVERDOSES MEAN MORE ORGANS FOR TRANSPLANTATION, HARVARD STUDY SHOWS

May 30 - The opioid epidemic ravaging the U.S. is killing tens of thousands a year, with over 63,600 overdose deaths in 2016. Although opioid prescriptions have started falling, the crisis is not abating. When pills aren't available, many users turn to heroin or its more dangerous cousin, fentanyl. But a strange phoenix has risen from these ashes: life-saving organs available for transplantation. After Mandeep Mehra and a colleague at Harvard Medical School noticed an increase in the number of donors, they tracked the source to opioid-related deaths. Newsweek spoke with Mehra, a professor of medicine, about the discovery of this disconcerting correlation.

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Don't Miss our 10th Anniversary of the Declaration of Istanbul @ TTS2018

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This workshop will comprise a half-day morning program addressing common ethical and clinical dilemmas in the management of organ donation and transplantation cases that may involve organ trafficking, and a half-day afternoon program exploring the update to the Declaration of Istanbul on Organ Trafficking and Transplant Tourism in the context of persisting and emerging issues in this field.

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Jayme Locke, TTS Young Members Committee Co-CHair wins ACTS Distinguished Investigator Award

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May 23 - The honor, received by Jayme Locke in April at the Association for Clinical and Translational Science Conference in Washington, D.C., is presented to a senior investigator whose innovative research or education leadership has had a major impact on or through clinical and translational science, specifically in applying translational research findings into effective public policies that promote health.

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Researchers Want To Show HIV-Positive Organ Donation Is Safe And Can Save Lives

A large-scale clinical trial launched by the National Institutes of Health in May could pave the way for more HIV-positive patients with kidney disease to receive life-saving transplants.

The trial, called the HOPE in Action Multicenter Kidney Study, will assess the risks of transplanting kidneys from HIV-positive donors into patients living with the virus, says Dr. Christine Durand, assistant professor of medicine at Johns Hopkins University and a principal investigator of the study.

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NIH Blog - Seven More Awesome Technologies Made Possible by Your Tax Dollars

May 31 - We live in a world energized by technological advances, from that new app on your smartphone to drones and self-driving cars. As you can see from this video, NIH-supported researchers are also major contributors, developing a wide range of amazing biomedical technologies that offer tremendous potential to improve our health.

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Transplantation - Featured Article

Submitted by Dr Karen Keung, Editorial Fellow, Transplantation.

Terasaki Epitope Mismatch Burden Predicts the Development of De Novo DQ Donor-Specific Antibodies and are Associated With Adverse Allograft Outcomes
Willicombe M, Blow M, Santos-Nunez E, Freeman C, Brookes P, Taube D.
Transplantation. 102(1):127-134

In predicting the development of de novo donor specific antibodies (DSA), recent data suggests that matching at the epitope level is superior to matching at the antigen level. HLA DQB1 antibodies are the most common de novo donor-specific antibodies (DSA) detected postrenal transplantation. In this retrospective study of renal transplant recipients, the authors compared the immunogenicity of the different HLA antigens, individual DQB1 alleles, and DQB1 Terasaki-defined Epitopes (TerEp), to determine whether DQ epitopes determined by Terasaki could more accurately predict de novo DQ development over HLA antigen matching (n=1003, mean follow up 4.28 ± 2.18 years posttransplant); 198 (19.74%) kidney transplant recipients developed de novo DSA of which 88 (44.4%) developed a DSA against a DQB1 mismatched antigen. In patients mismatched at a single DQB1 allele, the risk of de novo DQ DSA development increased with the number of TerEp mismatches, although the immunogenicity of the different DQ TerEps did not appear to be equal. Antibody mediated rejection-free survival was inferior in all patients with an antibody against TerEp epitopes. These data show that epitope mismatch burden determined by TerEps helps predict risk of de novo DQ DSA development and offers an alternative approach to predict an alloimmune response, which can further aid immunologic risk assessment.

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A 'wake-up call' about what's killing America's young people

(CNN)There has been a significant rise in accidental deaths, homicides and suicides among young people across the United States, and experts are calling it a wake-up call. The total death rate for 10- to 19-year-olds in the United States declined 33% between 1999 and 2013 but then suddenly soared 12% between 2013 and 2016, according to a new report from the National Center for Health Statistics at the US Centers for Disease Control and Prevention.

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In the News

Precision medicine taking the individual's whole genome into consideration

May 25 - Precision medicine has the potential to transform drug therapy and patients' lives. A recent study published in Human Genomics brings us closer to unlocking that potential.

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Indy 500 drivers don't like to talk about organ donation, but it's becoming their cause

May 24 - At the Indianapolis Motor Speedway Stefan Wilson's race car trumpets from its sidepods, its prime patch of advertising space, in bold letters: "Driven 2 Save Lives." It's a slogan of the Indiana Donor Network, one of Wilson's chief sponsors. The aim is to encourage people to register as organ donors.

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Pulmonary Hypertension Has Adverse Effect on Post-Lung Transplant Survival

May 25 - Pulmonary hypertension (PH) confirmed by preoperative cardiac catheterization is associated with the prognosis of Asian patients after lung transplantation for end-stage lung disease, according to the results of a study published in the Journal of Thoracic Disease.

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Most Transplant Recipients in One Place: Baskent University Breaks World Record

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On May 12, 2018, Baskent University set out to break the Guinness World Record for the largest group of organ transplant recipients in one place at one time. 457 transplant patients from all four corners of Turkey travelled to Ankara to take part in the "New Life Journey: Atatürk Walk and Run" organized by Başkent University at their Bağlıca Campus in Ankara.

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New Study Will Probe Safety of HIV-to-HIV Kidney Transplants

May 19 - A new study may pave the way for HIV-positive patients to receive organ transplants. The National Institutes of Health this month announced the launch of the HOPE in Action Multicenter Kidney Study to research the safety of kidney transplantation from HIV-positive donors to HIV-positive recipients.

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IS THIS STEM-CELL CLINIC REALLY MAKING CANCER VACCINES?

May 16 - ON THE FIRST Saturday of March, Kristin Comella put on a white doctor's coat and took the stage at the fourth annual conference for the Academy of Regenerative Practices. The founder and president of the academy, Comella also oversees an expanding empire of stem cell clinics that promise patients cures for most anything that ails them. None of those treatments—for everything from diabetes and asthma to multiple sclerosis and arthritis—have been approved by the US Food and Drug Administration.

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3D Printing Saves Toddler's Life with Kidney Transplant

kidneyMay 19 - In a pioneering operation, surgeons use 3D scanning and 3D printing to verify that a father's kidney would fit in his young son's abdomen before a live-saving kidney transplant.

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Transplantation - Featured Article

Submitted by r Joel Thomas Adler, Editorial Fellow, Transplantation.

Health care costs for the evaluation, surgery, and follow-up care of living kidney donors
[published online April 19, 2018]
Habbous S, Sarma S, Barnieh L, et al.
Transplantation. doi: 10.1097/TP.0000000000002222

Living donor kidney transplantation is widely practiced, but the cost of evaluation for donors is very poorly understood. Much of this cost is assumed to be due to the nephrectomy itself, but no formal studies have accounted for repeat testing, additional testing due to incremental findings, and consideration of other tests that are needed because of the donor's personal medical history. Habbous et al studied the health care costs of 1099 donors in Ontario, Canada. The incremental costs were found to be $16 290 (for the donor) for the entire evaluation, perioperative, and 1-year follow-up periods. The perioperative cost varied significantly across transplant centers. These data provide a useful framework to make care of the living donor more cost effective. Note, those costs may vary in different health care systems!

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Scientists have transplanted memory from one snail to another. So, what does it mean for humans?

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May 17 - It's the kind of study science fiction dreams are made of: A team of neurobiologists at UCLA "transplanted" a memory from the nervous system of one snail into another.

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In the News

Researchers uncover clues to early lung transplant failure

May 22 - Among organ transplant patients, those receiving new lungs face a higher rate of organ failure and death compared with people undergoing heart, kidney and liver transplants. One of the culprits is inflammation that damages the newly transplanted lung.

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Researchers build artificial cellular compartments as molecular workshops

May 22 - How to install new capabilities in cells without interfering with their metabolic processes? Scientists have altered mammalian cells in such a way that they formed artificial compartments in which sequestered reactions could take place, allowing the detection of cells deep in the tissue and also their manipulation with magnetic fields.

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Crusaders disease re-emerges despite liver transplants

May 17 - Health professionals on Thursday said it was imperative for Cyprus to stay updated on the latest research on amyloidosis, also known as Crusaders' disease, after it emerged that the disease re-emerges in a significant number of people who have undergone liver transplant.

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Robots grow mini-organs from human stem cells

May 17 - A robotic approach to mass-producing organoids could accelerate regenerative medicine research and drug discovery.

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