Chronic pancreatitis (CP) is a severe illness which may cause significant deterioration of patients well-being because of constant pain. Pancreatic cancer and diabetes are co-morbities which often follow CP. Pancreatic resection following pancreatic islets autotransplantation might be a successful therapeutic option for selected group of those patients. Unfortunately liver cirrhosis, portal vein thrombosis or hepatic virus infection (B or C) make standard transplantation into portal vein impossible. Alternative implementation sites might be an option for those patients. Successful islets transplantation into gastric sub-mucosa in pre-clinical study on pigs (1,2)  makes gastric submucosa promising option for future. Aim of this study was to report a successful resection of the pancreas and endoscopic islets autotransplantation into gastric sub-mucosa in man. Patient and methods. A 53-year old man with alcohol related chronic pancreatitis for 15 years was operated on 14^thof march 2013. In anamnesis: 3 months earlier patient was diagnosed with type 2 diabetes – only dietary treatment. Suffering with chronic pain treated with opioid analgesics, 16-years ago underwent antrectomy due topeptic ulcer perforation, also HBS-Ag positive and diagnosed with thrombosis of right portal vein. Patient underwent pancreatectomy  and splenectomy modo Child. Pancreas was immediately flushed with 1000 ml of UW solution through splenic artery and vein and sent to isolation facility. Islets were isolated, Cobe procedure was not performed. Endoscopic gastric sub-mucosa transplantation was performed 6 hours later. Levels of fasting c-peptide was measured prior to procedure and 1,2,3,4,5,7,14 and 30 days post autotransplantation. C-peptide stimulation (CPS)test was performed prior to procedure and one month post autotransplantation. Fasting glicemia and oral glucose tolerance test (OGTT) was performed prior and 7 and 30 days post transplantation. Control gastroscopy and endoultrasonography (EUS) were performed within first week post-trasnplantation.  Results: Isolation: 250 000 IEq (unpurified) was isolated – 3700 IEq/ kg of patients’ body weight. Pellets had 6 ml and was suspended in 60 ml of ringer solution. Transplantation: 18 injection was performed -3 to 5 ml of islets suspension was introduced into submucosa  of gastric trunk and fundus. No  complication during procedure was observed. Post-operative period: Patient did not require any insulin nor oral hypoglicemics post operation. In early post-operative patient underwent pneumonia and pulmonary embolism successfully treated with antibiotics and Low Molecular Weight Heparin. POST-procedure gastroscopy did not revealed any signs of inflammation or ulceration. EUS did not revealed any fluid collections within gastric wall. PRE-procedure fasting c-peptide was 1.23 ng/ml. POST-procedure C-peptide was(in 1,2,3,4,5,7,14,30 days): 1.11, 1.27, 0.55, 0.94, 1.08, 0.55, 0.69, 1.2, 1.09 ng/ml, respectively. PRE-procedure CPS-test in 0,5,10,15,30,60,120 min was: 1.22, 1.06, 1.35, 1.71, 4.39, 9.63,5.07 ng/ml, respectively. POST-procedure CPS-test was: 1.09, 1.13, 1.31, 3.9, 5.22, 3.82, 1.93 ng/ml, respectively. PRE-procedure OGTT in 0, 5, 10, 15, 30, 60, 120 min was: 85, 91, 98, 98, 167, 210, 76 mg/dl respectively. POST-procedure OGTT was: 96, 116, 127, 191, 224, 153, 68 mg/dl. Conclusion. Preliminary results of endoscopic gastric sub-mucosa islets autotransplantation showsthat it might be an alternative option for islets autotransplantation in case of patients with contraindication for transplantation into portal vein.