Overview

CMV is the most common infection after solid organ transplantation. Through optimal method of prevention, diagnosis, and treatment of CMV, overall outcomes can be significantly enhanced. Guidelines have been developed that encourage best practices, which will be reviewed. In recent years, multiple new agents with activity against CMV have appeared on the horizon, and their role in management of transplant patients will be mentioned. In addition, novel diagnostics may help manage complex patients. Advances in the field, as well as novel concepts and expert opinions, will be covered in this talk.

Objectives

1.       Understand the differences and nuances among various viral load diagnostics, including use of the international standard for CMV viral load testing

2.       Appreciate various methods of prevention including universal prophylaxis, preemptive therapy, and a hybrid approach

3.       Consider the potential for cellular immune assays and their impact on prevention, treatment, and overall outcomes

4.       Interpret clinical resistance of CMV to antiviral therapy and proceed with best approaches to management