In The News - Volume 1 - Issue 13 - October 9, 2015

University of Michigan team helps perform first kidney transplants in Ethiopia
A University of Michigan-led team performed the first kidney transplants in Ethiopia last week, after spending more than two years to help establish a transplant center in the  African country.
U-M Transplant Surgeon Jeffrey D. Punch, M.D. led a team that did three kidney transplants at St. Paul’s Hospital Millennium Medical College in Addis Ababa, Ethiopia. The transplants were done on three people who received kidneys from living donors. All of the patients, recipients and donors, are doing well. [More]

Better donor-recipient match with genomics
Now, a large international team of transplant surgeons and scientists has come together to investigate the genetic factors behind transplant successes and failures. The project involves more than three dozen research institutions around the world, including the McGill University and Génome Québec Innovation Centre, and is called the International Genetics & Translational Research in Transplantation Network (iGeneTRAiN).
Their efforts are detailed in a pair of papers published today in Genomic Medicineand in the journal Transplantation (available online soon); co-authors of the Transplantation paper include Jiannis Ragoussis, McGill University and Génome Québec Innovation Centre, and Chee L. Saw, from McGill University Health Centre. [More]

Womb transplantation approved for 10 British women
The first British baby to be born as a result of womb transplantation could arrive as soon as 2017, after doctors in the UK have given the green light for a clinical trial in which 10 British women will undergo the procedure
Last year, Medical News Today reported on the world's first ever successful birth from a transplanted womb in a 36-year-old woman from Sweden.
The woman - who wishes to remain anonymous - was born without a womb. After receiving a donor womb from a 61-year-old family friend, she gave birth to a healthy baby boy named Vincent.
Now, doctors from Imperial College London in the UK have given their ethical approval for a clinical trial that will involve performing the procedure on 10 British women without wombs, giving them the opportunity to carry their own babies. [more]

New formula predicts liver volume for live donor liver transplantation
A new formula developed by researchers in Switzerland and Japan was accurate in calculating standard liver volume in recipients of living donor liver transplantation, according to study data published in the Journal of Hepatology. To create this formula, liver volumes of 180 Japanese donor candidates from a tertiary care Japanese hospital between March 2006 and December 2013 and 160 Swiss patients with normal livers treated at a tertiary care Swiss hospital between January 2001 and April 2014 were analyzed by researchers. The data was randomly divided into a test subtest and validation subtest sample, stratified by race. The new formula was then performed on 50 living donor liver transplant (LDLT) recipients. [More]

Male birth control: Organ transplant drugs could hold the answer to developing 'pill'
Two drugs usually given to organ transplant patients could hold the answer to developing a male birth control “pill”, according to new research. 
Studying mice, researchers led by Haruhiko Miyata of Osaka University’s Research Institute for Microbial diseases, identified a version of calcineurin only found in sperm. This version contains a protein called PPP3CC.
They found mice with sperm unable to make, or that made low amounts, of the protein had sex with female mice but didn’t make them pregnant, suggesting an absence of PPP3CC induced infertility in the mice.
The study, published in Science, discovered that sperm with low PPP3CC made the part of the sperm connecting the head to the tail extremely rigid.

New hydrogel can keep stem cells alive for heart repair
The study used a hydrogel to protect and nourish stem cells bound for injection and differentiation into heart muscle cells. It used rats with damaged hearts and attempted to fix the damage by injecting their cell-laced hydrogel, “re-muscularizing” the area and fixing the characteristic damage of a heart attack. The hydrogel worked like a charm; when injected into the hearts of rats, the hydrogel saw about 73% of the stem cells survive, compared with just 12% survival while suspended in a normal injection fluid. [More]

Lack of Organ Donors Reins in Demand for Organ Transplant Immunosuppressant Drugs; Market to Decline at CAGR of -5.0% till 2023: Transparency Market Research
According to a new market report published by Transparency Market Research "Organ Transplant Immunosuppressant Drugs Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2015 - 2023," the global organ transplant immunosuppressant drugs market was valued at US$5.1 bn in 2014 and is expected to decline at a CAGR of - (5.0)% from 2015 to 2023, to reach an estimated value of US$3.2 bn in 2023. [More]

Liver transplantation prolongs DFS in pediatric HBL, HCC
Liver transplantation combined with chemotherapy provided long-term DFS in pediatric patients with advanced hepatoblastoma and hepatocellular carcinoma, according to the results of a retrospective analysis.
Favorable outcomes with transplantation persisted even among patients with hepatocellular carcinoma (HCC) larger than Milan and University of California, San Francisco (UCSF) criteria for transplant eligibility, results also showed. [More]

Consortium Tackles Transplant Genetics With More Than 30K Donor, Recipient Samples
NEW YORK (GenomeWeb) – Members of the International Genetics and Translational Research in Transplantation Network (iGeneTrain) are banding together to apply genomics to transplantation studies in the hopes of better understanding and improving transplant patient outcomes. In a paper in press in the journal Transplantation, the team described the goals and progress made so far for the iGeneTrain effort. When the paper was submitted, that work included 22 genetic studies, though the tally now comes in closer to 30 studies, according to information on the iGeneTrain web site. [More]

It takes two livers to save an obese patient
An obese man requiring liver transplant had to seek donation from two of his family members as the portion of liver donated by one was not sufficient.
Sameer Mitra, 46, weighed 93kg. Doctors had to take out 220 grams of the liver lobe from his brother-in-law, and another 550gm from his brother-in-law's wife to conduct the life-saving procedure.

Study Does Not Support Significant Role of CMV Virus In Transplant Outcomes
Dr. Erdbruegger: Controversy exists whether CMV infections or viremia after kidney transplantation affect patient and graft survival.
We aimed to explore the role of CMV in a retrospective study on almost 600 patients followed at our transplant center over a period of up to 10 years post-transplant. The analysis included protocol biopsy findings and causes for graft failure and death.

Global Gene Therapy Market Outlook 2015-2020
According to this new research report Global Gene Therapy Market Outlook 2020, a major focus has been on the ongoing clinical trials for the development of innovative products. In this context, the study provides a comprehensive overview of various aspects of the clinical trials in the gene therapy market, such as phases, geographies, vector types, etc. As indicated by the new estimation carried out in our most recent study, the global gene therapy industry can possibly turn into a multi-million dollar industry by the end of 2020, as new products, particularly those in the advanced stage of clinical studies or with pending approvals, may enter the market to boost the growth.

Commercialization of New Technologies Driving Big Market Growth in Nanomedicine, According to BCC Research
According to the new report from BCC Research, Global nanomedicine market was valued at $214.2 billion in 2013 and $248.3 billion in 2014. The total market is projected to grow at a compound annual growth rate (CAGR) of 16.3% from 2014 through 2019 and reach $528 billion by 2019. Increasing market penetration by existing products and the commercialization of new technologies are spurring double-digit growth in the nanomedicine market. BCC Research reveals in its new report that these trends will strengthen, leading the market to more than double in value during the forecast period.

A price tag for human organs
Malaysia - A new Act aimed at stopping the illegal organ trade involving Malaysian patients is currently being studied by the Attorney-General’s Chambers.
To deter such trading, the Organ and Tissue Transplantation Bill was drafted and is currently with the Attorney-General’s Chambers for further deliberation.
The new law is set to ban organ trading and regulate living organ donations, i.e. organ donations by people who are still alive.
Currently, the Human Tissues Act 1974, which will be replaced by the new Act, only governs organs donated after the donor is dead and is silent about organ trading.

Belfast hospital equals UK organ transplant record
Belfast City Hospital has equalled a UK record for the number of transplants carried out in a single day, after it carried out five kidney transplants in 24 hours.
The number of procedures on 13 September was one short of the world recordof six transplant surgeries held by a hospital in Texas, USA.
Fourteen doctors, 20 nurses and three scientists were involved in the Belfast procedures and several operating theatre nurses came into work on their day off to facilitate the huge surgical undertaking.