Dr. Bottino is a world-renowned expert in pancreas and islet cell biology and transplantation. She served as the Director of the Islet Isolation Laboratory, first, at the University of Pittsburgh and, subsequently, at Allegheny Health Network. In conjunction with the Cleveland Clinic, her lab pioneered the utility of remote clinical islet isolation as part of total pancreatectomy and autologous islet transplantation. As the Director of the core, she has prioritized the ability to function as a Core Resource to assist investigators by providing the specialized or rare islets they require for their studies. The Bottino Lab has an unmatched record of islet isolations from pancreatic organs obtained from deceased human donors of all ages, including newborn.
Dr. Bottino has an extensive expertise in the isolation of islet cells from pigs, monkeys and rodents for research purposes, for experimental transplantation, as well as in developing models of diabetes in animals, in particular monkeys. Dr. Bottino conducted pioneer studies on the use of genetically engineered pigs as islet donors for xenotransplantation in immunosuppressed diabetic nonhuman recipients, demonstrating long-term normalization of blood glucose levels in recipients. Dr. Bottino currently serves as a Councilor of the IXA from North America. She has published >150 peer-reviewed articles in high impact journals, including Nature Medicine, Nature Communication, Lancet, Cell, Cell Rep, J Clin Invest, JCI Insight, Gastroenterology, and many more.