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Tribune Pulse - June 13, 2019 - Volume III - Issue 23

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Just Released - Transplantation - June Issue

Hot topics this month include issues of patient navigation for recipients and both assessment and care of living donors counterpoised with standardization of outcome measures for clinical trials in transplantation. Liver transplant allocation in Europe and liver retransplantation in North America are of great importance, and interesting data may change approaches in the future. Reviews of the impact of sex and gender accompany reviews of subclinical inflammation and fibrosis. Enough for summer reading on the beach?

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TTS Biennial Congress Locations to Rotate by Region

During its March 2019 meeting, the TTS Council discussed the method of selecting locations for its biennial congresses.

In the past, a call-for-bids was issued at large to all members of TTS regardless of location. The bids were then analyzed and a location selected based on various criteria, including capabilities of the sponsoring society and venue, budgets, safety, travel connections for our worldwide members, etc. These criteria while all valid largely disregarded the global leadership role of TTS to help develop transplantation in all six TTS Regions: North America, Europe, Latin America, Asia, Middle East & Africa, and Oceania. As a result, since 1980 and projected to 2022, the TTS Biennial Congress was awarded 8 times to North America, 8 times to Europe, 3 times to Asia, twice to Oceania, and once to Latin America; it has not been awarded once to Middle East & Africa.

As a change from previous years, the TTS Council has decided during its March meeting that it would be more appropriate for future congresses to take place on a rotation among all of the TTS Regions represented, and that this rotation should begin with the 2024 congress to be held in the Middle East & Africa Region as it is the only region that has not yet organized a TTS congress. For this reason, the bids for the 2024 and future TTS Biennial congresses will be made by invitation only.

Invitations to bid for the 2024 congress have therefore been sent to the Middle East Society for Organ Transplantation (MESOT) and the Southern African Transplantation Society (SATS).

Beginning 2026, a fixed rotation to TTS Regions will take place, starting with the Region that has not held a congress for the longest time. This will mean that the rotation will be Oceania in 2026, North America in 2028, Europe in 2030, Asia in 2032, Latin America in 2034 and back to Middle East & Africa in 2036.

Of course, if a viable bid is not presented from the scheduled Region, alternative bids will be sought.

If you have any questions regarding this process, please contact the TTS Executive Director (This email address is being protected from spambots. You need JavaScript enabled to view it. ).

Transplantation - Highlighted Article

Dr. Andrea Schlegel, Editorial Fellow, Transplantation

The Relationships Between Cold Ischemia Time, Kidney Transplant Length of Stay, and Transplant-Related Costs

Serrano OK, Vock DM, Chinnakotla S, et al.
Transplantation 2019; 103 (2): 401-411

On the background of a changed organ allocation policy with the aim to equally serve candidates waiting for a kidney transplantation in all regions, authors of this interesting manuscript have developed statistical models to assess the impact of cold ischemia time (CIT) on the rate of delayed graft function (DGF) and length of hospital stay (LOS).

The statistical analysis is based on the entire kidney recipient population in United States, transplanted between 2006 and 2014. Outcomes after kidney transplantation in the authors‘ own center were compared to the UNOS population. Interestingly, authors found a higher DGF rate in the national population (25.7%), when compared to their own centers (17.8%), where machine perfusion was used more frequently as well. A 10 hour increase in CIT was associated with a 41% increase in the adjusted odds of DGF. Preemptive transplants and the use of machine perfusion was associated with reduced rates of DGF. Additionally, an increase in CIT led to a prolonged hospital stay mediated through higher DGF rates and subsequently elevated cost. The overall message, that a quicker kidney implantation with subsequent reduction of cold ischemia time or improved kidney quality by application of machine perfusion, will not only reduce DGF rate but also achieve a reduction of LOS and related costs is of great clincial importance. The authors should be congratulated for their paper. Further studies in this field are of great interest.

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Webinar | Learn how easy it is to apply for the ISN-TTS Sister Transplant Centers Program

When?

June 24 AT 2 PM CEST. Check when this webinar is happening in your timezone, here.

Speakers

Peter Kerr, Chair of the ISN Sister Centers Programs, and Philip J. O’Connell, Past-President of The Transplantation Society and Director of Transplantation, will guide you through each step of the application process.

They will share some handy tips on how to prepare a successful application and answer any questions you may have.

About the ISN-TTS Sister Transplant Centers Program

The ISN-TTS Sister Transplant Centers Program link renal and transplant centers in low-resource countries with established centers so they can benefit from educational support and work together to increase opportunities for kidney patients.

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Prof. Haberal Receives Honorary Fellowship of the Royal College of Physicians and Surgeons of Glasgow

Prof. Mehmet Haberal, President of The Transplantation Society, was selected by the Royal College of Physicians and Surgeons of Glasgow to receive Honorary Fellowship, which is presented only to those distinguished individuals who possess an international reputation in the field of surgery or medicine.

Prof. Mehmet Haberal with RCPSG President Prof. Jackie Taylor and RCPSG Past-President Prof. David Galloway following the ceremony

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A few words about SPLIT – the newest TTS section

Photo taken of the 2019 Council at our Mid-Year Meeting in Rockville, Maryland.

Back row (from left to right): Jeff Mitchell, Simon Horslen, Riccardo Superina, Marcelo Cantarovich, Beau Kelly, Jennifer White, Ravinder Anand, Katie Tait, Sue Feist
Front row (from left to right): Saeed Mohammad, George Mazariegos, Vicky Ng, Evelyn Hsu, Nitika Gupta, Steve Lobritto, Sue Rhee, Dana Mannino

The Studies of Pediatric Liver Transplantation (SPLIT) was started in 1995 and has evolved from a voluntary research registry into a multi-faceted organization focused on research, education, quality improvement, patient advocacy, mentorship, and improving outcomes for children receiving liver transplantation. Work from the SPLIT data registry was modeled to help develop the disease severity scoring system (PELD) for children. SPLIT held NIDDK U01 funding between 2004 and 2009. The organization has continued to grow in scope and membership, but remains constant with the unwavering vision to be the voice for children requiring liver transplantation. In 2018, SPLIT incorporated, changed its name to The Society of Pediatric Liver Transplantation (allowing retention of its longstanding SPLIT acronym), acquired tax-exempt status (501c(3)), and became the newest section of The Transplantation Society.

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TRANSPLANTATION - WEEK'S MOST DOWNLOADED PAPER

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IN THE NEWS

Researchers Discover that Some Cells in the Pancreas and Liver Don't Replicate, Just like Brain Cells

June 7 - The most common way of looking at our age is the number of days or years since we were born. But biologists sometimes look at aging differently, because the cells in our body we have today are not necessarily the original cells we were born with. But sometimes they are.

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Long-term islet transplant recipients show near-normal glucose control

June 8 - Continuous glucose monitoring demonstrates improved time-in-range, key metabolic data compared to hybrid closed-loop systems.

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Tissue Engineering: The Big Picture on Growing Small Intestines

June 8 - Babies born prematurely often face intense medical challenges, including intestines that are underdeveloped or diseased. While an intestine transplant can benefit some patients, many babies are simply too small to endure this procedure.

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Updated AST IDCOP Guidelines for Vaccination of Organ Transplant Recipients

June 5 - Based on emerging data on live-attenuated and inactivated vaccines, the American Society of Transplantation Infectious Diseases Community of Practice (AST IDCOP) released updated recommendations for the vaccination of solid organ transplant candidates and recipients.

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New drug regimens improve outcomes for kidney transplant patients

June 5 - Preliminary results suggest that the immunosuppressive drug belatacept can help safely and effectively treat kidney transplant patients without the negative long-term side effects of traditional immunosuppressive regimens.

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Upcoming Meetings and ANNOUNCEMENTS

CAST 2019 - Reduced Registration ends June 30

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TOND-TDTD - Save the dates - October 10-11, 2019!

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The 3rd Joint Meeting of the Turkish Transplantation Society and the Turkic World Transplantation Society will be held in Tashkent, Uzbekistan on October 10-11, 2019. The Scientific and Local Organizing Committees, comprised of international transplantation leaders, have developed a program that reflects current problems and represents a collection of scientific, educational, and practical information. The meeting will be an exciting opportunity for transplant professionals to share their expertise as well as their concerns regarding the development of the field in their own countries.

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International Transplantation Science Meeting 2019

ITS 2019 is set for Nov. 10-13 in Clearwater Beach, Florida. Keynote speakers include Katherine High, President and Head of R&D at Spark Therapeutics, and Ronald Germain, chief of Laboratory of Immune System Biology and Lymphocyte Biology Section at the National Institute of Allergy and Infectious Diseases National Institutes of Health.

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IPITA 2019 LYON - France

Registration is open and preliminary program is available.

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TID2019 - REGISTRATION NOW OPEN!

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IXA 2019 - Registration is Open - Early-Bird Ends July 15!

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TTS-ISODP - Save the dates - November 14-16, 2019!

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CTRMS 2019 – Lesvos - Greece

Late-Breaking and Poster Abstract Submissions are now being accepted!

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CIRTA 2019 - PARIS, FRANCE

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ISVCA 2019 - New Delhi, India - Save the dates - September 30 - October 1, 2019!

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