Our goal is to address the gaps in knowledge that remain in the field of pediatric liver transplantation and ultimately improve outcomes in children receiving liver transplants. We believe the best way to meet this goal is through the SPLIT clinical research network which is composed of transplant centers that have proven that they are capable to conduct clinical research and answer important questions in the field. We have updated the overall research focus of the Network and expanded the scope of research to be conducted to include quality improvement/comparative effectiveness studies and clinical trials in addition to a core observational study. Observational research conducted through the Network will identify opportunities for quality improvement efforts or alternatively identify gaps in knowledge which serve as a foundation for patient-based research. Quality improvement efforts and/or research projects will be conducted and then applied to the clinical arena through type 2 translational research which seeks to translate new and existing findings into improvement in clinical practice.