The clinicopathological conference will discuss a solid organ transplant recipient with post-transplant central nervous system (CNS) infection. The presenters and expert panelist will discuss the differential diagnoses and the diagnostic approaches including novel microbiologic tests.
To discuss differential diagnoses of brain lesions in a solid organ transplant recipient
To discuss diagnostic approach to brain lesions in solid organ transplant recipient
To discuss novel microbiologic tests for central nervous system infections
Wright AJ, Fishman JA. Central nervous system syndromes in solid organ transplant recipients. Clin Infect Dis. 2014;59(7):1001-11.
Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med. 2007;357(25):2601-14.
Azar MM, Gaston DC, Kotton CN, Malinis MF. Emerging Microbiology Diagnostics for Transplant Infections: On the Cusp of a Paradigm Shift. Transplantation. 2020 Jul;104(7):1358-1384.
Maricar Malinis Moderator
Yale School of Medicine
I joined the faculty of the Section of Infectious Diseases in 2013. I am an Associate Professor of Medicine with secondary appointment in the Department of Surgery (Transplant). I am the Medical Director of Transplant and Oncology Infectious Diseases Program.
I obtained my bachelor of science in Chemistry at the University of Philippines Diliman and my medical degree at the University of Philippines College of Medicine. I completed internal medicine residency at Seton Hall Graduate Medical Education. Afterwards, I did fellowships in Geriatric Medicine at University of Michigan, Infectious Diseases at University of Louisville, and Transplant Infectious Diseases at Cleveland Clinic Foundation.
I am an active member of the American Society of Transplantation (AST) and the AST Infectious Diseases Community of Practice (IDCOP). I am currently the Chair of the AST IDCOP Older Adult Working Group which is focused on clinical outcomes of transplant-related infections in older adults. In addition, I am currently the Member-at-large of the AST ID COP and Councilor of the Transplant Infectious Diseases Section of the Transplantation Society. I am also an active member of the Infectious Diseases Society of America and currently a Committee Member of the Clinical Affairs Committee and Digital Advisory Group. In 2020, I completed my 3-year term as a Member-at-large of Organ Procurement Transplant Network Ad hoc Disease Transmission Advisory Committee .
I am involved in clinical teaching of medical students, residents and fellows. Due to growing interest in Transplant Infectious Diseases, we created a curriculum specific for 2nd year ID fellows who want pursue a career in this field. Since 2015, we had 6 fellows who completed a 2nd year Clinical Track focused on Transplant Infectious diseases.
My research is focused on clinical outcomes of transplantation in people living with HIV and older adults. I have participated in several multi-center studies, including clinical trials. I am the primary investigator of the HOPE Act study at Yale and several multi-center clinical trials of novel anti-viral agents for immunocompromised hosts.
Daniel Kaul Presenter
University of Michigan United States Bio
Daniel Kaul MD is a professor of internal medicine in the division of infectious disease and the University of Michigan. He directs the transplant infectious disease service as well as the infectious disease training program. He has been the local principal investigator on numerous investigator initiated, federally funded, and industry sponsored clinical trials.
Rick holds membership in the North American Transplant Coordinator’s Organization, the American Society of Transplant Surgeons and the American Association of Tissue Banks. Rick is a past President of the American Board of Transplant Certification and holds certifications as a Certified Procurement Transplant Coordinator and a Certified Transplant Preservationist. Rick has delivered lectures and educational sessions for over 70 organizations and professional societies in the U.S. and internationally. He has also contributed to over 30 publications in peer reviewed journals to improve the science of donation and transplantation. Rick obtained his Bachelor of Science degree in Biology from Pennsylvania State University and a Master of Forensic Science degree from George Washington University.
Ihab Kassab Presenter University of Michigan United States
Ihab Kassab received his medical degree from Hawler Medical University in Iraq. He completed his residency in Internal Medicine at Jersey Shore University Medical Center in New Jersey then followed by a Chief Medical Resident at Morristown Medical Center in New Jersey. In 2018, he Jointed Michigan Medicine as clinical instructor of medicine. His area of practice focuses on hospital medicine, education of medical students.
Marwan Azar Expert Discussant
Yale School of Medicine United States Bio
My clinical and research interests lie at the intersection of Infectious Diseases and Clinical Microbiology, particularly in the application of emerging technologies for the diagnosis of infections in immunocompromised hosts including transplant recipients. I am also especially interested in diagnostics and treatment for invasive fungal infections, a common and often devastating infection in this population. Though novel diagnostics, such as metagenomic sequencing of clinical specimens, hold significant promise in providing early, accurate and hypothesis independent results, my training as a clinical pathologist has shed light on their potential drawbacks and the need for result validation within specific populations. Through carefully constructed studies, I plan to analyse the accuracy and utility of these diagnostics in the population of patients that I care for, in hopes that they can be later integrated into standard diagnostic algorithms.
Carlos Isada Expert Discussant
Cleveland Clinic Foundation United States Bio
Dr. Isada is currently Vice Chairman of the Department of Infectious Diseases at the Cleveland Clinic. He is a former Infectious Diseases Fellowship Program Director from 1994-2019, with an interest in Problem Based Learning in graduate medical education. His clinical activities are mainly in the section of Neurologic Infectious Diseases at the Cleveland Clinic. He holds a Joint Appointment in Clinical Pathology, Section of Clinical Microbiology.
Organized in collaboration with the TID Official Journal
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