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CTRMS Webinar - Promoting regeneration through mitochondrial transfer-mediated vascular regeneration and anti-inflammatory biomaterials

12265.1 - Promoting regeneration through mitochondrial transfer-mediated vascular regeneration and anti-inflammatory biomaterials

Presenter: Juan Melero-Martin, Kam W. Leong, , ,
Authors: Juan Melero-Martin, Kam W. Leong, Alice Tomei, Ekaterine Berishvili Berney

Overview

Dr. Melero-Martin will discuss how mitochondrial transfer through tunneling nanotubes or mitochondria transplantation enhances endothelial cell engraftment and could improve treatments for limb ischemia and myocardial infarction.

Dr. Leong will discuss the design of biomaterials such as nucleic acid-binding polymers to regulate inflammation by scavenging effects and/or targeted delivery of therapeutic agents to inflamed sites for enhanced bioavailability and minimized systemic side effects.

Learning Objectives

  1. Understand the challenges of endothelial cell engraftment and vascularization for treatment ischemic conditions
  2. Understand the mechanisms of mitochondrial transfer and mitophagy
  3. Therapeutic application of mitochondrial transfer for endothelial cell regeneration
  4. Understand the importance of regulating inflammation
  5. Understand how to use biomaterials to control inflammation
  6. Therapeutic application of nucleic acid-binding polymers as a novel approach for managing inflammatory diseases

Supporting material

Lin RZ, Im GB, Luo AC, Zhu Y, Hong X, Neumeyer J, Tang HW, Perrimon N, Melero-Martin JM.
Mitochondrial transfer mediates endothelial cell engraftment through mitophagy.
Nature. 2024 May;629(8012):660-668. doi: 10.1038/s41586-024-07340-0. Epub 2024 May 1. PMID: 38693258.

Alice Tomei, USA
Moderator
Bio

Ekaterine Berishvili Berney, Switzerland
Moderator
Bio

Juan Melero-Martin, USA
Speaker
Bio

Kam W. Leong, USA
Speaker
Bio

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