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CTRMS Webinar - Targeting Donor Aging and Cellular Senescence

1227.1 - Targeting Donor Aging and Cellular Senescence: Innovations in Regeneration and Transplantation

Presenter: Stefan G. Tullius, Nathan LeBrasseur, Alice Tomei, Ekaterine Berishvili, , ,
Authors: Stefan G. Tullius, Nathan LeBrasseur, Alice Tomei, Ekaterine Berishvili

Overview

Dr. Tullius will discuss innovative strategies to rejuvenate and optimize older donor organs, addressing the persistent challenge of organ shortages in transplantation. He will focus on cutting-edge approaches to mitigate ischemia-reperfusion injury, reduce functional decline, and tackle age-related augmented immunogenicity.

The webinar will highlight recent advancements in organ preservation and perfusion technologies, as well as the potential of senotherapeutics to enhance the viability and functionality of older organs. Dr. Tullius will also delve into the interaction between donor and recipient age, exploring the possibility of rejuvenating older organs when transplanted into younger recipients. These novel approaches have the potential to significantly narrow the gap between organ supply and demand, offering transformative solutions for end-stage organ failure.

Dr. LeBrasseur will discuss the groundbreaking advancements in understanding the molecular and cellular damage that accumulates with age, making aging the greatest risk factor for chronic conditions such as cardiovascular disease, Alzheimer’s disease, diabetes, cancer, and lung diseases. This seminar will explore the innovative hypothesis that addressing aging itself could delay or even prevent the onset of age-related diseases and disabilities, thereby extending human healthspan.

A key focus of the webinar will be cellular senescence—a cell fate triggered by various forms of damage—and its role in organ deterioration and dysfunction. Dr. LeBrasseur will highlight compelling evidence from preclinical models demonstrating that genetic and pharmacological elimination of senescent cells can improve the function of multiple organ systems. Additionally, the presentation will feature emerging data from human studies that underscore the potential of senescent cell-targeting therapies as a novel approach to revolutionize health and aging.

Learning Objectives

  1. Understand role of cellular senescence in aging and disease
  2. Understand the mechanisms of cellular senescence in aging
  3. Explore innovative strategies to rejuvenate donor organs and improve transplant outcomes
  4. Discover cutting-edge therapies targeting aging to enhance tissue regeneration and healthspan.

Supporting MAterials

Iske J, Roesel MJ, Martin F, Schroeter A, Matsunaga T, Maenosono R, Tripathi U, Xiao Y, Nian Y, Caldarone BJ, Vondran FWR, Sage PT, Azuma H, Abdi R, Elkhal A, Pirtskhalava T, Tchkonia T, Kirkland JL, Zhou H, Tullius SG.
Transplanting old organs promotes senescence in young recipients
Am J Transplant. 2024 Mar;24(3):391-405. doi: 10.1016/j.ajt.2023.10.013. Epub 2023 Oct 31.

Cummings SR, Lui LY, Zaira A, Mau T, Fielding RA, Atkinson EJ, Patel S, LeBrasseur N.
Biomarkers of cellular senescence and major health outcomes in older adults
Geroscience. 2024 Dec 18. doi: 10.1007/s11357-024-01474-9. Epub ahead of print.


Alice Tomei, USA
Moderator
Bio

Ekaterine Berishvili, Switzerland
Moderator
Bio

Stefan G. Tullius, USA
Speaker
Bio

Nathan LeBrasseur, USA
Speaker
Bio

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