Clinical Reader in Renal Pathology
Imperial College London London, UK
Dr. Candice Roufosse (MD PhD FRCPath) is a Clinical Reader in Renal Pathology in the Centre for Inflammatory Diseases (CID), Dept Immunology & Inflammation, Imperial College London. She is also an Honorary Consultant and Subspecialty Lead for Renal and Electron Microscopy, North West London Pathology, affiliated to Imperial College Healthcare NHS Trust. She is Subspecialty Advisor for Renal and Transplant at the Royal College of Pathologists and leads the UK Renal Pathology Network, under the umbrella of the UK Kidney Association. She is Counsellor for the Renal Pathology Society.
Dr Roufosse carries out translational research in kidney and transplant kidney pathology, with a focus on the application of gene expression analysis and advanced imaging technologies to improve diagnosis, including digital pathology and AI. She is a trial pathologist for clinical trials in transplantation and glomerulonephritis. Particular areas of expertise are transplant rejection and paraprotein-related renal injury.
Consultant, Division of Anatomic Pathology
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Science Rochester, Minnesota, USA
Lynn D. Cornell, M.D. is a Professor of Laboratory Medicine and Pathology at Mayo Clinic in Minnesota. Dr. Cornell completed residency in Anatomic and Clinical Pathology, followed by a Renal Pathology fellowship, at Massachusetts General Hospital. She received a Ruth L. Kirschstein National Research Service Award (NIH) for a post-doctoral research fellowship with Dr. Robert Colvin. Since 2007, she has worked at Mayo Clinic as a renal pathologist. Dr. Cornell established a renal pathology fellowship program at Mayo Clinic in 2013 and serves as the program director. Dr. Cornell received the Gloria Gallo Research Award from the Renal Pathology Society. She has served as Councilor for the Renal Pathology Society since 2023.
Professor, Attending Renal Pathologist
Cedars-Sinai Medical Center, Los Angeles, California USA
Mark Haas is a renal pathologist at Cedars-Sinai Medical Center in Los Angeles, CA, USA, and Professor of Pathology, Cedars-Sinai Professorial Series. He is a past president of the Renal Pathology Society (2008) and was the recipient of its Jacob Churg Award for Outstanding Contributions in Renal Pathology in 2012 and Robert H. Heptinstall Lifetime Achievement Award in 2023. He currently serves on the editorial boards of Kidney International (since 2002), Clinical Nephrology, and Histopathology (International Editorial Advisory Board), and was an Associate Editor of the American Journal of Transplantation from 2014-2021. He also served on the Program Committee for the Banff Conferences on Allograft Pathology from 2011 - 2019, chairing this Committee for the 2013 and 2017 conferences. His main interests are glomerular diseases, especially IgA nephropathy, and kidney transplant pathology.
Transplant nephrologist, University Hospitals Leuven
Leuven, Belgium
Maarten Naesens is a transplant nephrologist at the University Hospitals Leuven. Next to the clinical duties, he performs translational research at the Department of Microbiology, Immunology and Transplantation at the KU Leuven, focusing on risk factors, diagnosis, and impact of kidney transplant rejection. From 2024 onwards, he is Associate Editor of Kidney International, the official journal of the International Society of Nephrology (ISN) and is involved in the organization of the European Society of Organ Transplantation (ESOT) and Banff congresses. He has published more than 290 peer-reviewed articles in the field of kidney transplantation.
Professor of Clinical Pathology and Laboratory Medicine
Weill Cornell Medicine/New York Presbyterian Hospital
New York, USA
Surya V Seshan MBBS, is a Professor of Pathology and Laboratory Medicine and Director of Electron Microscopy laboratories at Weill Cornell Medicine, Chief, Renal Pathology Division, New york-Presbyterian Hospital, New York, NY, USA. Dr. Seshan is a past President of the Renal Pathology Society, and has served as a co-investigator in several university-and NIH-funded grants for both basic and translational research dealing with transplant rejection with Dr. Manikkam Suthanthiran’s group, and other experimental models of disease. She is an active participant and contributor to several international Consensus Conferences and Classification schema in native (currently lupus nephritis & TMA) and transplant renal diseases, being a member of several current and past Banff Schema Transplant Pathology Working Groups including BKV nephropathy, criteria for preimplantation renal biopsies assessment, antibody mediated rejection, pancreatic transplant biopsy studies, electron microscopy in renal transplant rejection, TMA, Activity & Chronicity indices in transplant pathology. She served on the editorial board of the journal Transplantation. She is currently the co-Director of the International Summer School in Renal Pathology and Precision Medicine, Univeristy of Bari, Italy since 2011, member of the International committee for classification of Antiphospholipid antibody Syndrome and member of the North American & Caribbean Regional of Governers associated with Internationational Society of Nephrology (ISN). She will assume the Chairmanship of the ISN Renal Pathology Working group from Feb 2025.
Overview
The Banff Activity and Chronicity Indices Working Group seeks a wider consensus from the International Transplant community in the development and incorporation of these indices in assessment of kidney transplant rejection, using the existing standardized and validated Banff lesion scores for the individual pathologic findings, for potential clinical utility and rationale for supplementing the pathology reporting of transplant kidney biopsies.
Learning Objectives
To review the current Banff kidney transplant rejection classification and its complex subcategories (active, chronic-active, chronic), from the clinical and the pathological perspective.
To justify the development of activity and chronicity indices based on Banff lesion scores, to simplify the evaluation of rejection activity and chronicity while adding precision.
To further discuss whether this could stratify patients for prognostic and therapeutic decisions, eventually replacing the subcategories of active, chronic-active and chronic forms of T-cell mediated and antibody mediated rejection.
Initiate active discussion and encourage input from the audience regarding the potential of activity and chronicity indices to predict prognosis, response to therapy and allograft outcome.
Supporting Material
Naesens M, Cornell LD, Seshan SV, Haas M. Towards activity and chronicity indices for the staging of kidney transplant rejection: a viewpoint by the Banff Working Group. Transplantation, Accepted for publication, Dec 2024.
Naesens M, Haas M. et al. Towards activity and chronicity indices for the evaluation of kidney transplant rejection: a viewpoint by the Banff Working Group. Transplantation 2025 (in press)
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