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MULTIDISCIPLINARY CARE MODEL FOR OPTIMAL MANAGEMENT OF THE NASH LIVER TRANSPLANT WAITLIST CANDIDATE - MAY 21, 2019
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    TTS Education Committee Webinar Series "Trends and Challenges in Liver Transplantation"
    TITLE: Multidisciplinary Care Model for Optimal Management of the NASH Liver Transplant Waitlist Candidate
    Tuesday, May 21, 2019 - 4:00 PM EDT (Montreal time)

    sukru Organizer: Sukru Emre, MD
    Professor of Surgery (Transplant) and of Pediatrics, Yale University
    New Haven, CT, USA
    Annmarie Huysman Liapakis Moderator: Annmarie Huysman Liapakis, MD
    Associate Professor of Medicine (Digestive Diseases), Yale School of Medicine
    New Haven, CT, USA
    Wajahat Mehal Discussant: Wajahat Mehal, MD, PhD
    Professor of Medicine (Digestive Diseases),
    Director of Yale Weight Loss Program,
    Director of Yale Fatty Liver Disease Program,
    Yale School of Medicine
    New Haven, CT, USA
    Andrew Posselt Discussant: Andrew Posselt, MD, PhD, FACS
    Professor of Surgery
    Director of Pancreatic Islet Transplant Program
    University of California, San Francisco School of Medicine
    San Francisco, CA, USA

    Objectives:

    Dr. Mehal will speak on implementation of multidisciplinary care model - pharmacologic weight loss therapy in advanced liver disease and special considerations for the sarcopenic obese patient.

    Dr. Posselt will speak on bariatric surgery: approach and special considerations in advanced liver disease.

    Wajahat Mehal's Biography:

    Dr. Mehal obtained his medical education at the University of Oxford England and completed his residency and GI fellowship at Yale University. He has been on faculty since 2001 and started the Fatty Liver Disease Program. He also leads a basic science research programs which examines the role of pattern recognition receptors and metabolic pathways in NASH. His work is funded by NIH grants and industry collaborations.

    Andrew Posselt's Biography:

    Dr. Andrew Posselt is an attending general and multi-organ transplant surgeon at UCSF and Director of the Pancreatic Islet Transplant Program. He specializes in adult and pediatric kidney, liver and pancreas transplantation as well as laparoscopic and open bariatric surgery. In addition to caring for patients, he conducts research on pancreatic islet transplantation, mechanisms of allograft rejection and tolerance, and the metabolic and biochemical consequences of bariatric surgery.

    Dr. Posselt is a professor-in-residence in surgery at UCSF, where he supervises residents and fellows in transplant services and general surgery. He earned medical and doctorate degrees in immunology from the University of Pennsylvania and completed an internal medicine residency, general surgery residency and transplant fellowship at UCSF, before joining the staff in 2003.


  • Medical and Surgical Aspects of Acute Liver Failure - April 24, 2019
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    TTS Education Committee Webinar Series "Trends and Challenges in Liver Transplantation"
    TOPIC: Acute Liver Failure
    TITLE: Medical and Surgical Aspects of Acute Liver Failure
    Wednesday, April 24, 2019 - 3:00 PM EDT (Montreal time)

    sukru Organizer and Moderator: Sukru Emre, MD
    Professor of Surgery (Transplant) and of Pediatrics, Yale University
    New Haven, CT, USA
    Manuel Rodriguez-Davalos Discussant: Manuel Rodriguez-Davalos, MD, FACS
    Transplant and Hepatobiliary Surgery
    Primary Children's Hospital - Intermountain Medical Center
    Salt Lake City, UT, USA
    Jody C. Olson

    Discussant: Jody C. Olson, MD, FACP
    Associate Professor of Medicine
    University of Kansas Medical Center
    Kansas City, KS, USA

    Manuel Rodriguez-Davalos' Biography:

    Manuel Rodriguez-Davalos, Medical Director, Living Donor Liver Transplantation Program, Intermountain Medical Center and Surgical Director, Pediatric Liver Transplantation, Primary Children's Hospital, Intermountain Healthcare. Dr. Rodriguez-Davalos has previously held positions in transplant at Yale University, Mount Sinai Medical Center and New York Medical College.

    He is committed to innovation and collaboration to improve organ donation, transplantation and allocation systems to benefit those in need, especially children. He has particular interest in living donor transplants, organ allocation, and portal hypertension.

    His current research involves living donor liver transplantation the use of partial grafts and extended criteria for donation in liver transplantation, and preservation techniques for decreasing ischemia-reperfusion injury.

    He has served on numerous liver transplantation advisory boards and was a member at large of the United Network for Organ Sharing (UNOS ) Liver Committee and as well as the pediatric transplantation committee. He is part of the publications committee with IPTA, Education committee of TTS, Associate editor of our journal “Transplantation”, Task force for liver allocation with SPLiT and oversees the International Liver Transplant Society Pediatric Liver Transplant Registry.

    He received his medical degree from the Anahuac University. He did a year of research in portal hypertension and hepatobiliary surgery at the National Institutes of Health System in Mexico. He was a surgical intern at the Mayo Clinic in Rochester, MN, and completed his surgical training at the Mayo Clinic Hospital in Scottsdale, AZ. He was a clinical fellow in multi-organ transplant surgery at Mount Sinai Medical Center.

    Jody C. Olson's Biography:

    Jody Olson is an Associate Professor of Medicine and Surgery at the University of Kansas Medical Center in Kansas City, Kansas. He attended medical school at the University of Nebraska Medical Center. He completed his internal medicine residency at the University of Minnesota under the CDC sponsored Global Health Pathway. After residency he completed advanced fellowships in Critical Care Medicine and Transplant Hepatology at Mayo Clinic in Rochester, Minnesota. Currently he practices both general and transplant hepatology and is an intensivist providing ICU care for both liver transplant patients and hepatobiliary surgery patients. His clinical research interests are centered on the intensive care management of patients with advanced liver disease. He serves as the site primary investigator for the US Acute Liver Failure Study Group at the University of Kansas.


  • Machine Perfusion in Liver Transplantation - January 30, 2019
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    TTS Education Committee Webinar Series "Trends and Challenges in Liver Transplantation"
    TITLE: Machine Perfusion in Liver Transplantation
    Wednesday, January 30, 2019 - 11:00 AM EST (Montreal time)

    sukru Organizer and Moderator: Sukru Emre, MD
    Professor of Surgery (Transplant) and of Pediatrics, Yale University
    New Haven, CT, USA
    Paolo Muiesan Discussant: Paolo Muiesan, FRCS, FEBS
    Professor and Consultant HPB Surgery & Liver Transplantation
    Queen Elizabeth & Birmingham Children's Hospitals
    Birmingham, UK
    Peter Friend

    Discussant: Peter Friend, MD, FRC
    Professor of Transplantation
    Consultant Transplant and HPB Surgeon
    Director Oxford Transplant Centre
    University of Oxford
    Oxford, UK


    Objectives:

    Dr. Muiesan will speak on the topic of Hypothermic Machine Perfusion.
    Dr. Friend will speak on the topic of Normothermic Machine Perfusion.

    Paolo Muiesan's Biography:

    Paolo Muiesan graduated in Medicine at the University of Brescia (Italy). He continued his education as acting intern in University of California Davis, as resident in General Surgery and then further specialized in Vascular Surgery at the University of Milan. He trained in adult and pediatric liver transplantation and hepatobiliary surgery at King′s College Hospital in London. To complete his training in HPB Surgery and Liver Transplantation he visited the University of Nebraska Medical Center and the University of Western Ontario in 1996 and Kyoto University Transplant Centre in 1998.

    He became Consultant Surgeon in HPB Surgery and Transplantation at King’s College Hospital in 1998 and moved to Birmingham Queen Elizabeth and Children’s Hospitals ten years later. He visited the Asan Medical Centre in Seoul in 2008 and 2009 in preparation to start the Living Donor Liver Transplant program in Birmingham and attended several courses on laparoscopic liver surgery. He became Professor in HPB Surgery and Transplantation at University of Birmingham in 2015.

    Professor Muiesan leads the living donor, auxiliary, domino and DCD liver transplantation programs in Birmingham. Other clinical and research interests include normothermic regional perfusion and machine perfusion as novel means of organ preservation for transplantation. His interests also include liver resections for cholangiocarcinoma, ALPPS and ex-situ, ante-situ liver resections.
    He currently leads the surgical program for treatment of cholangiocarcinoma. Further interests include pancreatic resections with vascular involvement and Appleby procedures, open and laparoscopic, and radiofrequency ablation of primary and secondary liver tumors.

    He served as Chair of the European Liver Intestine Transplant Association (ELITA) and Council Member of the European Society of Organ Transplantation (ESOT) from 2012 to 2015 and has been appointed Chair of the pediatric committee of the International Liver Transplantation Society (ILTS) and ILTS Council member in 2018. He joined by invitation the European Surgical Association in 2016. He has written 13 book chapters and is author/coauthor of over 210 publications.

    Peter Friend's Biography:

    Professor Peter Friend obtained his medical degree from the University of Cambridge (Magdalene College). He is a Fellow of the Royal College of Surgeons (Eng) and has a doctoral degree (MD) from the University of Cambridge. He is the Professor of Transplantation, University of Oxford and an Honorary Consultant Surgeon at Oxford University Hospitals NHS Foundation Trust, specialising in organ transplantation and hepatobiliary surgery. He is also Director of the Oxford Transplant Centre and Fellow of Green Templeton College.

    Peter has  authored more than 200 scientific papers, is a member of the Council of the Royal College of Surgeons and also of the International Transplantation Society. He is a past-president of the British Transplantation Society. Peter is also one of the co-founders of OrganOx, a spin-out company from the University of Oxford, established to develop novel ways to preserve and repair donor transplant organs.


  • Triage for Simultaneous Liver Kidney Transplantation and Clinical Pearls to Optimize Renal Protection After Liver Transplantation - November 6, 2018
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    TTS Education Committee Webinar Series "Trends and Challenges in Liver Transplantation"
    TITLE: Triage for Simultaneous Liver Kidney Transplantation and Clinical Pearls to Optimize Renal Protection After Liver Transplantation
    November 6, 2018 - 2:00 PM EST (Montreal time)

    sukru Organizer: Sukru Emre, MD
    Professor of Surgery (Transplant) and of Pediatrics, Yale University
    New Haven, CT, USA
    Marcelo Cantarovich Moderator: Marcelo Cantarovich, MD
    Professor, Department of Medicine, Division of Nephrology, Faculty of Medicine, McGill University
    Montréal, QC, Canada
    Annmarie Huysman Liapakis Discussant: Annmarie Huysman Liapakis, MD
    Assistant Professor of Medicine (Digestive Diseases), Yale School of Medicine
    New Haven, CT, USA
    Clifford D. Miles Discussant: Clifford D. Miles, MD, MS, FAST
    Associate Professor of Internal Medicine
    University of Nebraska Medical Center
    Omaha, NE, USA


    Objectives:

    1. To discuss triage strategies for liver transplant candidates with renal dysfunction requiring simultaneous liver kidney transplantation, versus liver transplant alone (based on clinical indication and UNOS policy compliance)
    2. To review international similarities and differences in combined organ allocation policies
    3. To learn how to optimize clinical management- monitoring and therapeutic strategies in patients with pre-existent renal dysfunction, and how to reduce the incidence of renal dysfunction after liver transplantation

    Annmarie Huysman Liapakis Biography:

    Dr. AnnMarie Liapakis is an Assistant Professor of Medicine and Surgery and practicing gastroenterologist with the Division of Digestive Disease, Department of Internal Medicine at Yale University and provides transplant hepatology care within the Yale New Haven Transplantation Center. She is a leader in the living donor liver transplant program and has created a subspecialty clinic for care of patients with combined kidney and liver disease within the transplantation center. She additionally has sub-specialty interest in viral hepatitis C and direct acting antiviral therapy in the context of transplantation. She currently serves as co-chairperson for Donate Life Connecticut and is the vice chairperson of education of the medical advisory committee of the CT chapter of the American Liver Foundation.

    Clifford D. Miles Biography:

    Dr. Miles is an associate professor of Internal Medicine at the University of Nebraska Medical Center, in Omaha, Nebraska. He joined the faculty there as a transplant nephrologist in 2007, and is now the Medical Director of kidney & pancreas transplantation for UNMC’s partner hospital Nebraska Medicine. Dr. Miles received his medical degree from the University of Nebraska, and then completed his residency in internal medicine at Dartmouth Hitchcock Medical Center in Lebanon, N.H. His training finished with fellowships in nephrology and transplant nephrology at the University of Michigan Medical Center, Ann Arbor. In June 2007, Dr. Miles also received a Master's of Science degree in clinical research and design and statistical analysis from the University of Michigan Medical Center's School of Public Health. Dr. Miles has served UNOS as a past regional representative to the Kidney Transplant Committee and current At-Large member of the Membership and Professional Standards Committee. He is also the Chair of the Heartland Kidney Network’s Medical Review Board.


  • Kidney Problems in Liver Transplantation - May 15, 2018
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    TTS Education Committee Webinar Series "Trends and Challenges in Liver Transplantation"
    TITLE: Kidney Problems in Liver Transplantation
    Tuesday, May 15, 2018 - 2:00 PM EDT (Montreal time)

    sukru Organizer: Sukru Emre, MD
    Professor of Surgery (Transplant) and of Pediatrics, Yale University
    New Haven, CT, USA
    Marcelo Cantarovich Moderator: Marcelo Cantarovich, MD
    Professor, Department of Medicine, Division of Nephrology, Faculty of Medicine, McGill University
    Montréal, QC, Canada
    Annmarie Huysman Liapakis Discussant: Annmarie Huysman Liapakis, MD
    Assistant Professor of Medicine (Digestive Diseases), Yale School of Medicine
    New Haven, CT, USA
    Clifford D. Miles Discussant: Clifford D. Miles, MD, MS, FAST
    Associate Professor of Internal Medicine
    University of Nebraska Medical Center
    Omaha, NE, USA


    Annmarie Huysman Liapakis Biography / Overview:

    Dr. AnnMarie Liapakis is an Assistant Professor of Medicine and Surgery and practicing gastroenterologist with the Division of Digestive Disease, Department of Internal Medicine at Yale University and provides transplant hepatology care within the Yale New Haven Transplantation Center. She is a leader in the living donor liver transplant program and has created a subspecialty clinic for care of patients with combined kidney and liver disease within the transplantation center. She additionally has sub-specialty interest in viral hepatitis C and direct acting antiviral therapy in the context of transplantation. She currently serves as co-chairperson for Donate Life Connecticut and is the vice chairperson of education of the medical advisory committee of the CT chapter of the American Liver Foundation.

    During the webinar Dr. Liapakis will cover:

    • Management of hepatorenal syndrome
    • Outcomes of hepatorenal syndrome, organ access
    • Indications for combined liver/kidney transplant
    • Learn how to optimize care of the cirrhotic patient to prevent hepatorenal syndrome

    Clifford D. Miles Biography / Overview:

    Dr. Miles is an associate professor of Internal Medicine at the University of Nebraska Medical Center, in Omaha, Nebraska. He joined the faculty there as a transplant nephrologist in 2007, and is now the Medical Director of kidney & pancreas transplantation for UNMC’s partner hospital Nebraska Medicine. Dr. Miles received his medical degree from the University of Nebraska, and then completed his residency in internal medicine at Dartmouth Hitchcock Medical Center in Lebanon, N.H. His training finished with fellowships in nephrology and transplant nephrology at the University of Michigan Medical Center, Ann Arbor. In June 2007, Dr. Miles also received a Master's of Science degree in clinical research and design and statistical analysis from the University of Michigan Medical Center's School of Public Health. Dr. Miles has served UNOS as a past regional representative to the Kidney Transplant Committee and current At-Large member of the Membership and Professional Standards Committee. He is also the Chair of the Heartland Kidney Network’s Medical Review Board.

    During the webinar Dr. Miles will cover:

    • Review the etiologies of kidney injury in the setting of liver disease
    • Discuss pathophysiology of hepatorenal syndrome
    • Know how to establish the diagnosis of hepatorenal syndrome


  • PSC/PBC and AIH - April 19, 2018
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    TTS Education Committee Webinar Series "Trends and Challenges in Liver Transplantation"
    TOPIC: PSC/PBC and AIH
    TITLE: Autoimmune Liver Disease 360º
    Thursday, April 19, 2018 - 3:00 pm DST (Montreal time)

    sukru Organizer/Moderator: Professor Sukru Emre, MD
    Professor of Surgery (Transplant) and of Pediatrics, Yale University, USA
    David Assis Discussant: David Assis, MD
    Assistant Professor of Medicine (Digestive Diseases)
    Yale School of Medicine New Haven, CT, USA
    Julie Heimbach Discussant: Julie Heimbach, MD
    Transplant Surgeon and Surgical Director of Liver Transplantation
    Mayo Clinic, Rochester, MN, USA


    David Assis Biography:

    Dr. David N. Assis is a hepatologist and assistant professor of medicine at Yale University School of Medicine. His training in liver diseases, including research fellowship and transplant hepatology, took place at Yale. He now focuses on autoimmune liver diseases in his clinical practice and also performs NIH-funded translational research to better understand the mechanisms of Autoimmune Hepatitis, Primary Biliary Cholangitis and Primary Sclerosing Cholangitis, and to develop new immune-based therapies for treatment of these disorders.

    Julie K. Heimbach Biography:

    Julie K. Heimbach, M.D., is a Professor of Surgery and the Chair of the Division of Transplantation Surgery at Mayo Clinic in Rochester, Minnesota. She is currently a member of the Governing Board of the American Association for the Study of Liver Disease; chair of the Communications Committee of the American Society of Transplant Surgeons; and chair of the Liver and Intestinal Transplant Committee of the OPTN/UNOS, the national organization charged with oversight of organ transplantation in the United States. She also serves as associate editor of the American Journal of Transplantation. Dr. Heimbach’s research focuses on living donor transplantation, obesity and transplantation, and liver transplantation for hilar cholangiocarcinoma.


  • Challenging Problems in Pediatric Liver Transplantation: Long Term Allograft Attrition - March 28, 2018
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    TTS Education Committee Webinar Series "Trends and Challenges in Liver Transplantation"
    Challenging Problems in Pediatric Liver Transplantation: Long Term Allograft Attrition
    Wednesday, March 28, 2018 - 2pm EST (Montreal)

    sukru Organizer/Moderator: Professor Sukru Emre, MD
    Professor of Surgery (Transplant) and of Pediatrics, Yale University, USA
    Esquivel Discussant: Carlos O. Esquivel, MD, PhD
    Arnold and Barbara Silverman Professor in Pediatric Transplantation,
    Stanford University School of Medicine, Stanford, CA, USA
    Horslen Discussant: Simon P. Horslen, MB ChB
    Director of the Hepatobiliary and Intestinal Failure programs
    Medical Director for Solid Organ Transplantation, Seattle Childrens Hospital, USA


    Overview:

    Dr. Simon Horslen would like to make the case that the most difficult and yet the most important problem we face in Pediatric Liver transplantation is long term allograft health. While short term outcomes have improved dramatically, the long-term rate of graft fibrosis and graft loss has really not changed, and because of the age of pediatric patients at the time of transplant most of the morbidity falls on the adolescents and young adults.


    Carlos O. Esquivel Biography:

    Carlos O. Esquivel is Professor of Surgery at Stanford University School of Medicine, Chief of the Division of Abdominal Transplantation and the Associate Director of the Institute of Immunity, Transplantation and Infection, an umbrella institute that fosters interdisciplinary research between basic scientists and clinicians. Dr. Esquivel is the first recipient of the Arnold and Barbara Silverman Professorship in Transplantation. He received his M.D. degree from the University of Costa Rica School of Medicine, completed general surgery training at the University of California Davis and then obtained a doctoral degree from the University of Lund in Sweden. He trained in transplantation of the liver, kidney, pancreas and intestine at the University of Pittsburgh under the direction of Dr. Thomas Starzl. In 1995, he was recruited to Stanford to start the Pediatric Transplant Programs at LPCH and rebuild the Adult Liver and Kidney Transplant Program.

    Dr. Esquivel is recognized worldwide as an expert and pioneer in transplantation. He is a creative and productive investigator having contributed 338 publications in the medical literature and given over 200 lectures throughout the United States and internationally. He oversees multiple basic science and clinical research projects and is currently PI for a 5-year, multi-center NIH grant to develop biomarkers for Epstein-Barr Virus-induced post-transplant lymphomas in children. As a transplant leader at Stanford and in key national and international societies, he promotes team cooperation, embraces change and creates an environment for fostering discovery, and for training leaders of the future. In recognition of his many contributions to surgical education, Dr. Esquivel received the American Society of Transplant Surgeons 2015 Francis Moore Excellence in Mentorship in the Field of Transplantation Award.

    Simon Horslen Biography:

    Simon Horslen MB ChB FRCPCH FAST FAASLD is a Professor in the Division of Pediatric Gastroenterology, Hepatology & Nutrition at Seattle Children’s Hospital and the University Of Washington School Of Medicine. He is Medical Director for Solid Organ Transplantation at Seattle Children’s Hospital. Dr. Horslen earned his medical degree at the University Of Bristol, England and is a Fellow and Founder Member of the Royal College of Paediatrics and Child Health.

    He has worked in the US for the last 20 years initially at the University Of Nebraska Medical Center and currently in Seattle. He is a Pediatric Hepatologist and Transplant Physician with many years’ experience of liver and intestinal transplantation in children. Dr Horslen participates in several multicenter research studies including SPLIT (Studies in Pediatric Liver Transplantation), PALF (Pediatric Acute Liver Failure) and ChiLDREN (Children’s Liver Disease Research Network). Dr Horslen is a past-Chair of the UNOS/OPTN Pediatric Committee and of the Pediatric Community of Practice of the American Society of Transplantation (AST). He is current Chair of SPLIT (Studies of Pediatric Liver Transplantation) and President Elect of IRTA (Intestinal Rehabilitation and Transplantation Association).


  • Antibody Mediated Rejection in Liver Transplantation Part I - Role of DSA's and Treatment Options - January 19, 2018
  • Date and time: January 19th, 2018 2:00 PM EST (UTC-5 hours)
    Topic: Antibody Mediated Rejection in Liver Transplantation Part I - Role of DSA's and Treatment Options
    Description: Antibody mediated rejection (AMR) has become one of the hot topics in liver transplantation recently. In this webinar, world known experts in this topic will discuss the immunological, clinical aspects of AMR as well as available treatment options.
    Format: Debate/Discussion

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    sukru Organizer: Professor Sukru Emre, MD
    Professor of Surgery (Transplant) and of Pediatrics, Yale University, USA
    Udeme Ekong Moderator: Udeme D Ekong, MD, MPH
    Associate Professor of Pediatrics (Gastroenterology), Yale University, USA

    wozniak Discussant: Laura J. Wozniak, MD, MS
    Associate Clinical Professor, Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition at UCLA, USA
    oleary Discussant: Jacqueline O'Leary, MD, MPH
    Medical Director of Research for the Baylor Simmons TransplantInstitute in Dallas, Texas, USA
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