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2024 - TTS Education Webinar Series
10727.7 - CMV in Transplantation: Facing Challenges and Advances
Presenter: Camille N. Kotton, Margaret R. Jorgenson, , , Authors: Camille N. Kotton, Margaret R. Jorgenson, Nicolas Mueller, Michelle Yong, Alessandra Mularoni, Cameron Wolfe
Outline
The webinar will cover CMV management, focusing on updates of the use of new drugs and methods of assessing immunity, in addition to discussing controversial aspects in CMV infection management and prevention. It will also address which metrics can be used to monitor and enhance disease treatment, as well as intervention strategies for optimizing drugs and diagnostic resources.
The webinar will consist of three 20-minute expository lectures and a 30-minute panel of experts discussing key points and answering audience questions. This will be case based to foster discussion.
Learning Objectives
To foster a critical view on CMV prevention strategies
To enhance understanding of the current evidence regarding the use of cell-mediated immunity assays in CMV management
Understanding the concept, diagnostic methods, and management of refractory and resistant CMV
To comprehend possible metrics and interventions to enhance the management of CMV infection and disease
Director, Infectious Disease and Infection Control Service, ISMETT
Alessandra Mularoni is Director of the Infectious Disease and Infection Control Service at ISMETI - a solid organ transplant center partner of the University of Pittsburgh-located in Palermo, Italy. At ISMETI she works as ID consultant for liver, kidney, pancreas, heart, and lung transplant programs for children and adults. She also works in hospital epidemiology and infection control. Since 2016 she has been Clinical Assistant Professor at the School of Medicine at the University of Pittsburgh. She is councilor of Transplant Infectious Disease (TID-TTS), of Italian Society of Antiinfective Therapy (SITA) and member of ESCMID.
Clinical Director, Transplant Infectious Disease
Department of Medicine, Infectious Disease Division
Massachusetts General Hospital
Camille Nelson Kotton is the clinical director of the Transplant and Immunocompromised Host Infectious Diseases Program in the Infectious Diseases Division at Massachusetts General Hospital, and an associate professor of medicine at Harvard Medical School in Boston, MA. She has worked in the field of transplantation since 2001. She was the president of the TTS Transplant Infectious Disease Section (2007-2014), chair of the American Society of Transplantation Infectious Disease Executive Committee (2014-2016), and serves as councilor for TTS (2020-2024) and secretary-elect (2024-), on the TTS Fundraising Committee, and co-chairs the TTS Education Committee since 2022. She has led four versions of the TTS-supported International Consensus Guidelines on CMV Management after Solid Organ Transplant (2008, 2012, 2017, 2024) and co-led the Second International Consensus Guidelines on the Management of BK Polyomavirus in Kidney Transplantation (2024), all published in Transplantation, where she serves as associate editor. She has a special interest in international transplant work and was integrally involved in the TTS-supported guidelines on Recommendations for Management of Endemic Diseases and Travel Medicine in Solid-Organ Transplant Recipients and Donors: Latin America (2018) and South Asian Transplant Infectious Disease Guidelines for Solid Organ Transplant Candidates, Recipients, and Donors (2023).
Clinical Pharmacist
Department of Pharmacy, University of Wisconsin Hospital
Margaret Jorgenson, PharmD, BCTXP is an infectious diseases trained clinical pharmacist with 15 years’ experience in abdominal solid organ transplant at UW Health. As founder and program lead of the CMV Stewardship initiative at this center, her focus is optimizing patient outcomes through quality improvement.
Head, University Hospital Zurich Transplant Center
Division of Infectious Diseases and Hospital Epidemiology
University Hospital Zurich
After graduation in 1990 (University of Zurich Medical School) Nicolas Mueller was Board certified in Internal Medicine in 1998 and in Infectious Diseases in 2004. In 2005 he was appointed senior lecturer at the University of Zurich and is a senior attending physician at the Division of Infectious Diseases and Hospital Epidemiology at the University Hospital Zurich.
His is involved in the routine care of transplanted patients. Basic research interests are viral infections in animal models of allo- and xenotransplantation, which he studied in the laboratory of Dr. Jay Fishman from 1998 to 2003. Currently, Dr. Mueller is involved in the Swiss Transplant Cohort Study on a local and national level and conducts epidemiological and translational studies in the field of transplant infectious diseases
Infectious Diseases Physician
Royal Melbourne Hospital and Peter MacCallum Cancer Centre
Melbourne, Australia
Michelle Yong MBBS FRACP MPH PhD is an Associate Professor in Infectious Diseases and Post-doctoral researcher at Peter MacCallum Cancer Centre, The Royal Melbourne Hospital and the National Centre for Infections in Cancer (NCIC), University of Melbourne, Australia.
She is an experienced clinician with a research interest in CMV and opportunistic infections in transplant and immune-compromised hosts having published widely on the understanding of CMV-related transplant outcomes and cytomegalovirus (CMV)-specific immunity. She sits on national and international guideline writing panels including the ASTCT guidelines on resistant and refractory CMV. A. Prof Yong is the current vice-president of the Immune-compromised Host Society (ICHS), member of the TAVI Forum and has editorial roles at Current Opinion Infectious Diseases and Clinical Microbiology Reviews. She leads a clinical trials unit and is principal investigator on numerous studies exploring novel viral and fungal therapeutics.
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