P-158

Skin cancer following pancreas transplantation

J. Spanogle, Y. Kudva, R. Dierkhising, W. Kremers, R. Roenigk, J. Brewer, M. Prieto, C. Otley
Mayo Clinic, Rochester, MN, USA

Skin cancer in pancreas transplant recipients has not been extensively characterized. We describe the incidence, tumor burden, and risk factors for skin cancer in 216 pancreas transplant recipients at Mayo Clinic from 1996-2006. Allogenic pancreas transplant recipients had a skin cancer cumulative incidence of 4.7%, 12.7%, and 19.6% by 2, 5, and 10 years post-transplant, respectively. For squamous cell carcinoma, the 2, 5, and 10 year cumulative incidence was 2.8%, 10.3%, and 16.7%, respectively; for basal cell carcinoma, the 2, 5, and 10 year risk was 2.4%, 7.8%, and 17.4%, respectively. For patients who developed a squamous cell carcinoma, the cumulative incidence of developing a second squamous cell carcinoma was 56% at 2 years; for patients who developed a basal cell carcinoma, the cumulative incidence of developing a second basal cell carcinoma was 36% at 2 years. Of the risk factors examined, only age and having a skin cancer prior to transplant was predictive for the development of skin cancer. Nonmelanoma skin cancers commonly occur in recipients of pancreas transplants, and those patients who have a prior history of nonmelanoma skin cancer have a very high likelihood of further skin cancer development.

P-158

Skin cancer following pancreas transplantation

J. Spanogle, Y. Kudva, R. Dierkhising, W. Kremers, R. Roenigk, J. Brewer, M. Prieto, C. Otley
Mayo Clinic, Rochester, MN, USA

Skin cancer in pancreas transplant recipients has not been extensively characterized. We describe the incidence, tumor burden, and risk factors for skin cancer in 216 pancreas transplant recipients at Mayo Clinic from 1996-2006. Allogenic pancreas transplant recipients had a skin cancer cumulative incidence of 4.7%, 12.7%, and 19.6% by 2, 5, and 10 years post-transplant, respectively. For squamous cell carcinoma, the 2, 5, and 10 year cumulative incidence was 2.8%, 10.3%, and 16.7%, respectively; for basal cell carcinoma, the 2, 5, and 10 year risk was 2.4%, 7.8%, and 17.4%, respectively. For patients who developed a squamous cell carcinoma, the cumulative incidence of developing a second squamous cell carcinoma was 56% at 2 years; for patients who developed a basal cell carcinoma, the cumulative incidence of developing a second basal cell carcinoma was 36% at 2 years. Of the risk factors examined, only age and having a skin cancer prior to transplant was predictive for the development of skin cancer. Nonmelanoma skin cancers commonly occur in recipients of pancreas transplants, and those patients who have a prior history of nonmelanoma skin cancer have a very high likelihood of further skin cancer development.