CTRMS Webinar - November 11, 2024

Promoting regeneration through mitochondrial transfer-mediated vascular regeneration and anti-inflammatory biomaterials

Monday, November 11, 2024 - 9:00 AM (Local time in Montreal)
Local time (Corresponding local time at your current location)
The duration of this presentation is scheduled for 60 minutes.

Overview

Dr. Melero-Martin will discuss how mitochondrial transfer through tunneling nanotubes or mitochondria transplantation enhances endothelial cell engraftment and could improve treatments for limb ischemia and myocardial infarction.

Dr. Leong will discuss the design of biomaterials such as nucleic acid-binding polymers to regulate inflammation by scavenging effects and/or targeted delivery of therapeutic agents to inflamed sites for enhanced bioavailability and minimized systemic side effects.

Learning Objectives

  1. Understand the challenges of endothelial cell engraftment and vascularization for treatment ischemic conditions
  2. Understand the mechanisms of mitochondrial transfer and mitophagy
  3. Therapeutic application of mitochondrial transfer for endothelial cell regeneration
  4. Understand the importance of regulating inflammation
  5. Understand how to use biomaterials to control inflammation
  6. Therapeutic application of nucleic acid-binding polymers as a novel approach for managing inflammatory diseases

Supporting material

Lin RZ, Im GB, Luo AC, Zhu Y, Hong X, Neumeyer J, Tang HW, Perrimon N, Melero-Martin JM.
Mitochondrial transfer mediates endothelial cell engraftment through mitophagy.
Nature. 2024 May;629(8012):660-668. doi: 10.1038/s41586-024-07340-0. Epub 2024 May 1. PMID: 38693258.

Alice Tomei, USA
Moderator
Bio

Ekaterine Berishvili Berney, Switzerland
Moderator
Bio

Juan Melero-Martin, USA
Speaker
Bio

Kam W. Leong, USA
Speaker
Bio

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Contact

Staff Directory
+1-514-874-1717
info@tts.org

Address

The Transplantation Society
International Headquarters
740 Notre-Dame Ouest
Suite 1245
Montréal, QC, H3C 3X6
Canada