The August issue of Transplantation Direct is online. This is an issue touching many areas of the transplantation field, including kidney, liver, lung, heart, intestinal, bone marrow and stem cell transplantation, as well as xenotransplantation. We offer reviews on monoclonal gammopathy of undetermined significance in kidney transplantation (Tx) and on protocols for anonymous living liver donation. There are articles on the topic on normothermic perfusion of DCD kidneys -- one relates to GWAS of key mitochondrial pathways in pig studies, and the other on regional organ perfusion programs. Another article looks at the effect of nephron mass in DCD kidneys regarding pediatric donation to adults. The subjects of other kidney Tx studies include HLA incompatible transplantation in sensitized patients, the impact of Mayo Adhesive Probability score in living donor transplantation, transplanting patients with pre-Tx pulmonary hypertension, outcomes in patients receiving dual basiliximab and ATG induction, and the association of HLA alleles with post-Tx diabetes. Liver transplant articles touch on allograft dysfunction related to DCD vs DBD grafts, long-term results from a prolonged-release tacrolimus trial, desensitizing recipients with preformed DSA, surgical aspects of interposition grafts for split livers, and transplanting organs from a SARS-CoV-2 positive living donors. Other topics relate to biomarkers for restrictive allograft syndrome after lung Tx, veno-arterial ECMO to bridge heart Tx, GvHD after intestinal Tx, and long-term effects of ABO mismatching on stem cell Tx. For those interested in xenotransplantation, mechanisms of neutrophil-induced tissue damage are explored. To unpack all the details, please visit our open access Transplantation Direct website.
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