This issue contains important early information on breakthrough COVID-19 infection in vaccinated transplant recipients from both the USA and UK. Clearly we are going to have to go for third and fourth vaccine shots in our patients. Research continues in many other important areas - Reviews of frailty in heart transplant recipients, mitochondrial dysfunction and kidney preservation are all highly informative. New studies in liver, heart, kidney and islet transplantation all have implications for clinical practice so there is much to read this month.
ISODP Members have been automatically registered to the event with a Zoom confirmation sent to their address on file. The event is also open and free to all healthcare and associated professionals with an interest in the field. The recordings will be accessible to ISODP and TTS members only.
This study shows that viral load decline in COVID-19 correlates with NK cell status and that NK cells can control SARS-CoV-2 replication by recognizing infected target cells. In severe COVID-19, NK cells show remarkable defects in virus control, cytokine production and cell-mediated cytotoxicity despite high expression of cytotoxic effector molecules.
From a total 1,137 articles retrieved, 13 were included in the systematic review and meta-analysis comprising 4,440 kidney transplant recipients (KTR). Compared with survivors, non-survivors were significantly older (WMD 10.5 years, 95% CI 9.3–11.8). KTR of deceased donor were at higher risk of death (OR 1.73, 95% CI 1.10–2.74).