Transplantation - November 2021 Issue

JUST RELEASED - TRANSPLANTATION - NOVEMBER ISSUE

This issue contains important early information on breakthrough COVID-19 infection in vaccinated transplant recipients from both the USA and UK. Clearly we are going to have to go for third and fourth vaccine shots in our patients. Research continues in many other important areas - Reviews of frailty in heart transplant recipients, mitochondrial dysfunction and kidney preservation are all highly informative. New studies in liver, heart, kidney and islet transplantation all have implications for clinical practice so there is much to read this month.

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ISODP 2021 Webinar Series - LAST CHANCE TO SIGN UP!

Join us for our upcoming 3-Day Webinar Series taking place virtually from November 1-3, 2021.

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ISODP Members have been automatically registered to the event with a Zoom confirmation sent to their address on file. The event is also open and free to all healthcare and associated professionals with an interest in the field. The recordings will be accessible to ISODP and TTS members only.


Upcoming Events and Webinars 

WIT-TTS Webinar | November 15

TID 2021 Virtual | November 17-18


Latest Video Additions

3rd International Congress
International Society of Uterus Transplantation

Friday October 8, 2021 - (12 videos)

1st IPTA VIRTUAL Fellows & Allied Health & Nursing Professionals (AHNP) Meeting

October 14-15 & 21, 2021 (3 videos)

Liver Transplantation and Anesthesia & Critical Care Involvement

Anesthesia and Critical Care Committee Webinar - October 27, 2021

Disease-modifying therapy in short bowel syndrome

IRTA Webinar - October 19, 2021

Hot Off The Press

«HOT OFF THE PRESS» 
RECENT PUBLICATIONS IDENTIFIED
BY TTS EDUCATION COMMITTEE ON COVID-19

Articles this week reviewed by Dr. Enver Akalin

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

Mario Witkowski et al.
Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. PMID: 34695836

This study shows that viral load decline in COVID-19 correlates with NK cell status and that NK cells can control SARS-CoV-2 replication by recognizing infected target cells. In severe COVID-19, NK cells show remarkable defects in virus control, cytokine production and cell-mediated cytotoxicity despite high expression of cytotoxic effector molecules.

Single-cell RNA-sequencing (scRNA-seq) of NK cells along the time course of the entire COVID-19 disease spectrum reveals a unique gene expression signature. Transcriptional networks of interferon-driven NK cell activation are superimposed by a dominant TGFβ response signature with reduced expression of genes related to cell-cell adhesion, granule exocytosis and cell-mediated cytotoxicity. In severe COVID-19, serum levels of TGFβ peak during the first 2 weeks of infection, and serum obtained from these patients profoundly inhibits NK cell function in a TGFβ-dependent manner. Our data reveal that untimely production of TGFβ is a hallmark of severe COVID-19 and may inhibit NK cell function and early virus control.

Mortality risk factors of COVID-19 infection in kidney transplantation recipients: a systematic review and meta-analysis of cohorts and clinical registries

Suwasin Udomkarnjananun et al.
Sci Rep. 2021 Oct 8;11(1):20073. doi: 10.1038/s41598-021-99713-y. PMID: 34625642

From a total 1,137 articles retrieved, 13 were included in the systematic review and meta-analysis comprising 4,440 kidney transplant recipients (KTR). Compared with survivors, non-survivors were significantly older (WMD 10.5 years, 95% CI 9.3–11.8). KTR of deceased donor were at higher risk of death (OR 1.73, 95% CI 1.10–2.74).

Comorbidities including diabetes mellitus, cardiovascular disease, and active cancer significantly increased mortality risk. KTR with dyspnea (OR 5.68, 95% CI 2.11–15.33) and pneumonia (OR 10.64, 95% CI 3.37–33.55) at presentation were at higher mortality risk, while diarrhea decreased the risk (OR 0.61, 95% CI 0.47–0.78). Acute kidney injury was associated with mortality (OR 3.24, 95% CI 1.36–7.70). Inflammatory markers were significantly higher in the non-survivors, including C-reactive protein, procalcitonin, and interleukine-6.

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