This month brings a focus on how and where we will get progress in clinical practice with '-omics', big data analysis and linkages. There is also a reminder to understand the fragility of the results we rely upon - robust or p values gone in a puff of wind. A beautiful review of the macrophage in transplantation will be important reading for most of us. The focus in liver transplantation remains IRI and the DCD donor, with concomitant interest in Biliary strictures. Angiotensi receptor antibodies are carefully analyzed in a single center heart transplant study. Long term use of Everolimus is analyzed in kidney transplant recipients, while an analysis of eGFR calculators does not inspire us to rely upon any of the 63 equations examined.
We invite all our members and the transplant community as a whole to present their latest research at the Congress. Choose among many submission topics and we are also offering abstract-based awards!
Accepted abstracts will be published in an online supplement of Transplantation.
This study assessed 52 COVID-19 household contacts to capture immune responses at the earliest timepoints after SARS-CoV2 exposure. Using a dual cytokine FLISpot assay on peripheral blood mononuclear cells, the frequency of T cells specific for spike, nucleocapsid, membrane, envelope and ORF1 SARS-CoV-2 epitopes that cross-react with human endemic coronaviruses were analyzed. Higher frequencies of cross-reactive (p = 0.0139), and nucleocapsid-specific (p = 0.0355) IL-2-secreting memory T cells in contacts who remained PCR-negative despite exposure (n = 26), when compared with those who convert to PCR-positive (n = 26); no significant difference in the frequency of responses to spike is observed, hinting at a limited protective function of spike-cross-reactive T cells. In summary, pre-existing non-spike cross-reactive memory T cells protecting SARS-CoV-2-naïve contacts from infection, thereby supporting the inclusion of non-spike antigens in second-generation vaccines.
The SARS-CoV-2 Omicron variant (B.1.1.529) contains mutations that mediate escape from antibody responses, although the extent to which these substitutions in spike and non-spike proteins affect T-cell recognition is unknown. This study shows that T-cell responses in individuals with prior infection, vaccination, both prior infection and vaccination, and boosted vaccination are largely preserved to Omicron spike and non-spike proteins. However, a subset of individuals (∼21%) with a >50% reduction in T-cell reactivity to the Omicron spike were indetified. Evaluation of functional CD4+ and CD8+ memory T cell responses confirmed these findings and reveal that reduced recognition to Omicron spike is primarily observed within the CD8+ T cell compartment potentially due to escape from HLA binding. Booster vaccination enhanced T-cell responses to Omicron spike. In contrast to neutralizing immunity, these findings suggest preservation of T-cell responses to the Omicron variant, although with reduced reactivity in some individuals.
In 2022, two Officer positions will be vacated and 5 of the 12 Councilors-at-large representing the Regions will be changing. The elections will take place early in 2022 and those elected will assume their new roles starting at the 2022 TTS Congress in Buenos Aires.
Members can access the online nominating form at www.tts.org/nominations. Since each nominee must have his or her form signed by three supporting members (including him/herself), the online process allows for efficient and rapid circulation.
For more information on elections, visit the TTS website and consult the By-Laws in the “About” section.
Recognized as the world's highest dedicated award for the most outstanding contributions in the field of transplantation.
THE INTERNATIONAL TRANSPLANTATION SCIENCE MENTEE-MENTOR AWARDS FOR THE 29TH INTERNATIONAL CONGRESS OF THE TRANSPLANTATION SOCIETY (TTS 2022) – BUENOS AIRES, ARGENTINA, SEPTEMBER 10-14, 2022.
The Transplantation Society celebrates the contributions of basic science to the field of transplantation with the International Transplantation Science Mentee-Mentor Awards to recognize the efforts of scientists who have advanced our understanding of transplantation science and fostered the development of the young investigators who will be the future leaders in our field.
The application will open in January 2022. Deadline for submission is April 10, 2022.Click here for more details