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Transplantation Updates

Transplantation - Highlighted Tweets

The effectiveness of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 Omicron variant in immunosuppressed solid organ and islet transplant (SOT) recipients is unclear.

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The original SARS-CoV-2 vaccination regimen (2 doses) induces insufficient short-term response in kidney transplant (KT) recipients. This study assessed the response to a third dose and the long-term immunogenicity after 2 doses in KT.

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Transplantation Direct - Highlighted Tweet

Targeting interleukin-6 (IL-6) was shown to counteract donor-specific antibody production and antibody-mediated rejection (AMR) activity. It is not known whether, or to what extent, IL-6 antagonism modulates biomarkers indicative of tissue damage (donor-derived cell-free DNA [dd-cfDNA]) and parenchymal inflammation (C-X-C motif chemokine ligand [CXCL] 10).

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ITS 2023 - Program Overview is now available!

Join us in Niagara-on-the-Lake from April 30 to May 3, 2023 for the 3rd International Transplantation Science Meeting!

CLICK HERE TO REGISTER

Highlights Include:

3 Keynote Speakers
8 Scientific Sessions
Pre-Workshop on "Emerging 'Omics' and Machine Learning Techniques: The Next Frontier in Transplant Research"
Numerous opportunities to network

Highlighted Meeting - MESOT 2023

View the Scientific Program!

The 18th Congress of the MESOT will be an ideal opportunity to share and learn from peers and in the field. State-of-the-art lectures, plenaries, oral presentations and poster receptions will stimulate deep discussions on the latest scientific research in all fields of organ transplantation in the Middle East, Mid Asia and the world.

MESOT 2023 will be held on May 24-26, 2023 in Ankara, Turkey, and is endorsed by The Transplantation Society (TTS), The Turkish Transplantation Society (TOND) and The Turkic World Transplantation Society (TDTD).

CLICK HERE TO VIEW AND DOWNLOAD THE PROGRAM

CLICK HERE TO VISIT THE WEBSITE

Women in Transplantation

Trainee WIT Pillar Member – Expression of Interest

WIT has recently opened a position on each of our Pillars for a trainee with a clinical or research focus in transplantation.

Please note that the position on Pillar 2 has already been filled.

The missions of each Pillar are as follows:

Pillar 1: Advancing and inspiring women transplant professionals
Pillar 3: Advocacy for equity in access to transplantation and donation

Please send your Expression of Interest to Katie Tait at katie.tait@tts.org.

Submission deadline: February 28, 2023

VISIT THE WIT HOMEPAGE FOR FULL DETAILS

Latest Recordings

View the recordings (CTRMS / TTS Members Only)

In the News

Whole Slide Imaging and AI can Improve Organ Transplantation, Study Shows

Feb. 3 - Today, many viable organs, particularly kidneys and livers, from deceased donors are more likely to be discarded because transplant biopsy reports are inconsistent, and manual reads of frozen section biopsy slides are labor-intensive. Together, the University of Utah and Techcyte explored whether implementing whole slide imaging and artificial intelligence could address this problem.

All of Us Research Program Participants Fuel Both Scientific and Personal Discovery

Feb. 7 - The NIH’s All of Us Research Program is a historic effort to create an unprecedented research resource that will speed biomedical breakthroughs, transform medicine and advance health equity. To create this resource, we are enrolling at least 1 million people who reflect the diversity of the United States.

Chilling Donors Not as Good as Machine Perfusion for Kidney Transplant

Feb. 4 - Therapeutic hypothermia of donors didn't preserve kidney function as well as machine perfusion of the organ during cold storage, a randomized trial found. Compared with kidneys pumped with a non-oxygenated, cold dialysate after removal, those obtained from brain-dead organ donors that underwent mild therapeutic hypothermia had significantly higher risk for delayed graft function.

Brain Blood Vessel Disease Halted by Bone Marrow Transplant

Feb. 3 - Preliminary research from the National Institute of Neurological Disorders and Stroke (NINDS), a division of the NIH, showed that bone marrow transplants prevented or improved blood vessel disease in the brains of adults with sickle cell disease.

Human brain organoids respond to visual stimuli when transplanted into adult rats

Feb. 2 - In a study publishing in the journal Cell Stem Cell, researchers show that brain organoids -- clumps of lab-grown neurons -- can integrate with rat brains and respond to visual stimulation like flashing lights.

More than 15,000 liver transplants performed in first two years of acuity circles policy

Feb. 1 - In the two years following the launch of the U.S. national liver allocation policy based on acuity circles, nearly 15,300 deceased donor liver-alone transplants were performed nationwide. This was an increase of 4.3 percent over the corresponding two-year period before implementation.

A New (Old) Drug Joins the COVID Fray, and Guess What? It Works

Feb. 8 - With SARS-CoV-2 sidestepping monoclonal antibodies faster than a Texas square dance, the need for new therapeutic options to treat — not prevent — COVID-19 is becoming more and more dire.

Study Shows Deadly Toll on MDs of Pandemic's Early Wave

Feb. 6 - An investigation that was published in April 2021 by The Guardian and Kaiser Health News found that more than 3600 US healthcare workers who responded to COVID-19 had died by then. Almost one third were nurses, and close to one fifth were physicians. A new study published today in JAMA Internal Medicine confirms that more US physicians died from March 2020 to December 2021 than usual.

'Exciting': Off-the-Shelf T-cell Therapy Shows Promise

Feb. 6 - Posoleucel, an investigational off-the-shelf T-cell therapy, showed promising safety and efficacy for eradicating multiple viruses in a phase 2 study of patients who previously underwent allogeneic stem cell transplant (allo-SCT).

FDA Approves First Oral Agent For Anemia in Kidney Dialysis Patients

Feb. 2 - The US Food and Drug Administration (FDA) has approved daprodustat (Jesduvroq), the first oral treatment for anemia caused by chronic kidney disease (CKD) in adults who have been on dialysis for at least 4 months.

Upcoming Meetings and Announcements

BTS (British) 2023

March 1-3, 2023
Edinburgh, UK

Bitish Transplantation Society 2023 Congress

BTS (Belgian) 2023

March 17, 2023
Brussels, Belgium

Belgian Transplantation Society 2023 Congress

IPTA 2023

March 25-28, 2023
Austin, Texas, USA

12th Congress of the International Pediatric Transplant Association

IPITA/HSCI/JDRF Beta Cells Summit

April 24-25, 2023
Cambridge, MA, USA

4th Stem Cell Derived Beta Cells Summit

ITS 2023

April 30-May 3 2023
Niagara-on-the-lake, Canada

3rd International Transplantation Science Meeting

MESOT 2023

May 24-26, 2023
Ankara, Turkey

18th Congress of the Middle East Society for Organ Donation

CIRTA 2023

June 30 - July 3, 2023
Chicago, USA

18th Congress of the Intestinal Rehabilitation and Transplant Association (CIRTA XVIII)

CAST 2023

August 25-28, 2023
Hong Kong

Congress of the Asian Society of Transplantation

SPLIT 2023

October 16-17, 2023
Montreal, Canada

27th Annual Meeting of the Society of Pediatric Liver Transplantation

ISODP 2023

October 18-21, 2023
Las Vegas, USA

16th Congress of the International Society for Organ Donation and Procurement

IPITA-IXA-CTRMS Joint Congress

October 26-29, 2023
San Diego, USA

Joint Congress of the
International Pancreas and Islet Association (IPITA)
International Xenotransplantation Association (IXA)
Cell Transplant and Regenerative Medicine Society (CTRMS)

TTS 2024

September 22-25, 2024
Istanbul, Turkey

30th International Congress of The Transplantation Society (TTS 2024)

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