Kidney transplant recipients have better survival rates and improved quality of life than long-term dialysis patients. However, delayed graft function, immunosuppressive therapy nephrotoxicity, and rejection episodes may compromise graft and patient survival. The KL gene is highly expressed in kidney tubular cells and encodes the antiaging and kidney-protective protein Klotho, which has membrane-anchored and soluble forms and regulates mineral metabolism.
In recent years, there have been calls for implementation of “epitope matching” in deceased-donor organ allocation policies (later changed to “eplet matching”). Emerging data indeed support the use of molecular mismatch load analysis in specific patient groups, with the objective of posttransplant stratification into different treatment arms. For this purpose, the expectation is to statistically categorize patients as low- or high-immune-risk. Importantly, these patients will continue to be monitored‚ and their risk category, as well as their management, can be adjusted according to on-going findings.
Few studies have addressed immunosuppression management after allograft failure (AF). Immunosuppression withdrawal to minimize complications must be balanced with the risk of sensitization and potentially reduced retransplantation. We aimed to determine relationships between immunosuppression, death, sensitization, and retransplantation among patients with AF.
Scarcity of donor hearts continues to be a challenge for heart transplantation (HT). The recently Food and Drug Administration–approved Organ Care System (OCS; Heart, TransMedics) for ex vivo organ perfusion enables extension of ex situ intervals and thus may expand the donor pool. Because postapproval real-world outcomes of OCS in HT are lacking, we report our initial experience.
Urinary tract infection after transplantation was identified by patients, caregivers and health professionals as an important infection.
We are inviting patients, caregivers and health professionals to complete a survey to identify what aspects of urinary tract infections are important, when designing a clinical trial to prevent transplant-associated urinary tract infections. These aspects may include the population to target, the treatments to evaluate, and the outcomes that are important to report in the trial. Participation is voluntary and anonymous, and you may exit the survey at any time.
Further information can be found on the Participant Information Sheet. All participants will receive a copy of the results. The survey will close March 31, 2023.
Please complete these questions on your own. By clicking “begin”, you are consenting for your data to be used for research purposes.
Click the following link to begin: Start survey or copy and paste the URL (https://uqmedicine.syd1.qualtrics.com/jfe/form/SV_d42Jdb9JDXvpG6i) into your Internet browser:
Your opinion will be valuable and important to help ensure that we consider the most important aspects of urinary tract infection in kidney transplant trials. Participation in this survey will not impact the care provided to patients in any way. If you have any questions, please email contact us at email@example.com
If you would like to speak to an officer of the University not involved in the study, you may contact the Ethics Coordinator at 617 3365 3924 / 617 3443 1656 or email (firstname.lastname@example.org)
Thank you for considering the invitation to participate.
The Women in Transplantation executive is very excited to announce the 2023 WIT funding opportunities. This year, we are thrilled to be able to support THREE 2-year Fellowships. This will be the third year that we are offering these fellowships.
In addition, for the first time, we are also offering ONE grant open to faculty working in low or middle income countries. This very special new grant will allow transplant professionals working in low and middle income countries to work with an experienced mentor from among the WIT membership to address an important question within their own unique context. We hope that this award will spur exciting international collaborations and build more research capacity in lower resource settings.