Thrombotic microangiopathy (TMA) is a rare and devastating complication of kidney transplantation, which often leads to graft failure. Posttransplant TMA (PT-TMA) may occur either de novo or as a recurrence of the disease. De novo TMA can be triggered by immunosuppressant drugs, antibody-mediated rejection, viral infections, and ischemia/reperfusion injury in patients with no evidence of the disease before transplantation. Recurrent TMA may occur in the kidney grafts of patients with a history of atypical hemolytic uremic syndrome (aHUS) in the native kidneys.
Trifecta (ClinicalTrials.gov #NCT04239703) is a prospective trial defining relationships between donor-derived cell-free DNA (dd-cfDNA), donor-specific antibody (DSA), and molecular findings in kidney transplant biopsies. Previous analyses of double results showed dd-cfDNA was strongly associated with rejection-associated molecules in the biopsy. The present study analyzed the triple results in 280 biopsies, focusing on the question of dd-cfDNA levels in DSA-negative antibody-mediated rejection (AMR).
Normothermic regional perfusion (NRP) has gained widespread adoption in multiple European countries. The aim of this study was to examine the influence of thoracoabdominal-NRP (TA-NRP) on the utilization and outcomes of liver, kidney, and pancreas transplantation in the United States.
Following the outbreak of coronavirus disease 2019 (COVID-19) in the United States, the number of kidney waitlist additions and living-donor and deceased-donor kidney transplants (LDKT/DDKT) decreased substantially but began recovering within a few months. Since then, there have been several additional waves of infection, most notably, the Delta and Omicron surges beginning in August and December 2021, respectively.
We are delighted to announce and invite you to “save the date” for the 41st Annual Scientific meeting (ASM) of the Transplantation Society of Australia and New Zealand (TSANZ) which will be held from Sunday 18 – Tuesday 20th June 2023 at the Brisbane Convention and Exhibition Centre in beautiful and sunny Brisbane, Queensland.
The TSANZ Scientific Program and Education Committee (SPEC), in conjunction with the TSANZ Council, have prepared an exciting program convened by Dr Chandima Divithotawela and A/Professor Antiopi Varelias.
This year's program features Plenary sessions from several renowned international speakers on recent advances in the areas of transplant immunology, xenotransplantation, emerging cellular therapies, chronic rejection and organ donation. Not limited to this, the program will also span transplant genetics, cutting-edge basic science topics, ethical issues of transplantation and will include a Women in Transplant (WIT) session.
As with previous years, this year, we are delighted to host three pre-ASM sessions including:
The annual Awards dinner with live entertainment will be held in the iconic Brisbane City Hall, a short stroll along the Victoria Bridge over the stunning Brisbane River. Besides networking opportunities, several social events are planned by the TSANZ Early Career Researcher Committee (ECRC) including:
We look forward to welcoming you to Australia’s River City in June 2023 for what will be an exceptional and exciting meeting!