Announcement - Councilor-at-Large for Oceania

We are pleased to announce that Germaine Wong has been nominated for the position of Councilor-at-Large for Oceania. As she is running unopposed, there will be no by-election, and Germaine will commence her service on the Council immediately.

Thank you for your continued support and engagement with The Transplantation Society.

Transplant Nephrologist
University of Sydney and Westmead Hospital

Bio

Upcoming Webinar Presentation

CLICK HERE FOR DETAILS

DICG Supported Publication

Policy and Legal Review of Organ Transplantation in Six Countries

With great efforts made by The Transplantation Society and other bodies, extensive guidelines have been formulated to assist the development of ethical organ transplantation. Such guidelines, supplemented by domestic regulatory frameworks have led to a decline in unethical transplant practices around the world. Nonetheless, organ trafficking and coercion and exploitation in matters of transplantation continue to be reported.

The Declaration of Istanbul Custodial Group (DICG) commissioned a study to analyse how organ transplant policies are implemented in six countries - India, Egypt, Philippines, Costa Rica, Pakistan, and Colombia.

The report summarizes barriers and facilitators to implementing the ethical principles and guidelines in domestic laws and policies that may guide countries in strengthening their policy frameworks to further safeguard ethical organ transplantation.

CLICK HERE TO DOWNLOAD THE FACT SHEET

CLICK HERE TO DOWNLOAD THE EXECUTIVE SUMMARY

CLICK HERE TO DOWNLOAD THE ANALYTICAL SUMMARY

VISIT THE DICG WEBSITE

ISN-TTS Sister Transplant Program Presentation

Grand Rounds in Transplant Nephrology – an ISN-TTS Sister Transplant Centres Initiative: Post-transplant diabetes in paediatric kidney transplant recipients

Post transplant Diabetes (PTDM) is a well-recognized complication after Kidney transplantation. Recent updates include recognition of impaired glucose tolerance, optimization of immunosuppression, prevention of PTDM and incorporation of new glucose lowering agents. Peri-transplant hyperglycemia is being increasingly identified and treated in paediatric population. We discuss a case series of children who developed post transplant hyperglycemia. Two of them were asymptomatic, two of them had high tacrolimus levels and two of them required insulin therapy. Optimization of immunosuppression and insulin therapy resulted in resolution of hyperglycaemia.

CLICK HERE FOR DETAILS AND TO REGISTER

Transplantation Journal Highlights

Transplantation - Social Media Content

Advancing the Scientific Basis for Determining Death in Controlled Organ Donation After Circulatory Determination of Death

In controlled organ donation after circulatory determination of death (cDCDD), accurate and timely death determination is critical, yet knowledge gaps persist. Further research to improve the science of defining and determining death by circulatory criteria is therefore warranted. In a workshop sponsored by the National Heart, Lung, and Blood Institute, experts identified research opportunities pertaining to scientific, conceptual, and ethical understandings of DCDD and associated technologies. This article identifies a research strategy to inform the biomedical definition of death, the criteria for its determination, and circulatory death determination in cDCDD.

Chronic Rejection After Kidney Transplantation

In kidney transplantation, ongoing alloimmune processes—commonly triggered by HLA incompatibilities—can trigger chronic transplant rejection, affecting the microcirculation and the tubulointerstitium. Continuous inflammation may lead to progressive, irreversible graft injury, culminating in graft dysfunction and accelerated transplant failure. Numerous experimental and translational studies have delineated a complex interplay of different immune mechanisms driving rejection, with antibody-mediated rejection (AMR) being an extensively studied rejection variant. In microvascular inflammation, a hallmark lesion of AMR, natural killer (NK) cells have emerged as pivotal effector cells.

Transplantation Direct - Social Media Content

The Post-transplant Lymphoproliferative Disorders—Metagenomic Shotgun Microbial Sequencing (PTLD-MSMS) Study Methods and Protocol

Post-transplant lymphoproliferative disorders (PTLDs) remain a feared complication of transplantation, with significant morbidity and mortality. The oncogenic Epstein-Barr virus (EBV) is a key pathogenic driver in 50%–80% of cases. Numerous prognostic indices, comprising multiple clinical, epidemiological and tumor characteristics, including EBV tumor positivity, do not consistently associate with worse patient survival, suggesting a potential role for EBV genome variants in determining outcome. However, the precision medicine tools for determining if a viral genome variant is pathogenic are very limited compared with human genome variants.

Continuous Renal Replacement Therapy During Long-term Normothermic Machine Perfusion of Human Donor Livers for up to 7 D

Normothermic machine perfusion (NMP) is used to preserve and test donor livers before transplantation. During NMP, the liver is metabolically active and produces waste products, which are released into the perfusate. In this study, we describe our simplified and inexpensive setup that integrates continuous renal replacement therapy (CRRT) with NMP for up to 7 d. We also investigated if the ultrafiltrate could be used for monitoring perfusate concentrations of small molecules such as glucose and lactate.