JUST RELEASED - Transplantation Direct - September 2025 Issue
The September issue of Transplantation Direct is loaded with content across an array of topics. First, we present a comprehensive series of 10 state-of-the-art mini-reviews on the topic of ECP (extracorporeal photopheresis) use in solid organ transplantation, emphasizing mechanisms of action and clinical applicability. In addition, we have articles on organ donation related to use of quarantine practices to prevent donor infection transmission, to Continuous Distribution policy for US kidney allocation, and to policies for determining transplant candidacy from the Consortium for the Holistic Assessment of Risk in Transplant (CHART). In lung transplantation, studies are presented on the use of anti-platelet agents in perfusion/transplantation, and on split heterotopic bilateral lung transplants. On the topic of gender in transplantation, post-transplant infections linked to menopause are explored, as well as patterns of sex differences related to waitlist mortality. In tissue reconstruction research, the use of sub-normothermic machine perfusion for forearm VCAs is examined. Experience in treating high-titer antibody-mediated rejection in ABO blood-type incompatible liver transplant recipients is presented in another article. Finally, in kidney transplantation, studies are presented on the use of immune checkpoint inhibitors to treat cancer in recipients, on CMV status as it relates to cognitive impairment, and on performance of transplants at less well-staffed times during the day. Please visit our Transplantation Direct website for all the details on these and other articles.
Cardiac Mitochondrial and Electrophysiological Changes in Transplanted Ovine Hearts Following Preservation by Hypothermic Oxygenated Perfusion
During heart transplantation (HTx), donor hearts are exposed to injury via brain death (BD) and cardiac preservation using static cold storage (SCS). Preservation using hypothermic oxygenated machine perfusion (HOPE) may reduce myocardial injury compared with SCS preservation. This study sought to better understand how the BD donor cardiac allograft is modified before HTx and posttransplant following HOPE preservation.
International Xenotransplantation Association (IXA) Position Paper on Kidney Xenotransplantation
Porcine kidney xenotransplantation for end-stage renal disease (ESRD) has reached the stage of clinical testing following major advances in donor pig genetic modifications and effective immunosuppressive strategies through decades of rigorous translational research. Reports of pig kidney xenograft survival beyond 1 year post-transplant in nonhuman primate (NHP) models justify optimism for its potential as an alternative to allotransplantation.
Is 2 h of Hypothermic Machine Perfusion for Pancreas Preservation Effective in Improving Graft Reperfusion?
Static cold storage (SCS) remains the standard method for organ preservation. The development of parenchymal edema during prolonged hypothermic machine perfusion (HMP) was a major barrier to the introduction of this technique for the preservation of pancreases. A short period of HMP could optimize the pancreas for reperfusion while minimizing the side effects related to perfusion. Our objective is to evaluate the impact of short-term HMP on the pancreatic reperfusion.
Modernizing the Design Process for US Organ Allocation Policy: Toward a Continuous Distribution Policy for Kidneys
The allocation of a limited supply of donor organs remains a critical challenge for organ transplantation. The analytical tools that policymakers rely upon for improving allocation policy have seen little advancement since the introduction of computer simulation in 1995. In recent years, simulation has increasingly become a bottleneck in the policy design process. Partnering with the Organ Procurement and Transplantation Network Kidney Transplantation Committee, our team introduced new analytical techniques into the policy design process.
The ISN and TTS join forces to support the training of young physicians from low resource areas receiving hands-on training in advanced host institutions to acquire state of-the-art knowledge in transplantation
The ISN-TTS Sister Transplant Centers Program is a joint partnership set up to create new kidney transplant centers and develop existing kidney transplant programs in emerging economies.
International Transplant Nurses Society (ITNS) Symposium - October 3–5
The Annual Symposium presented International Transplant Nurses Society features world-class speakers providing cutting-edge research and clinical information in transplant nursing. Attendees will have the opportunity to continue their professional education in a highly respected, stimulating environment, while earning continuing education credits and CEPTCs. TTS’ Allied Health Professional Committee Chair Estephan Arredondo will present on "Bridging Borders: Exploring Spain and Europe’s Legacy and Innovation in Transplantation”. ITNS' Annual Symposium is an ideal context to engage in innovative sessions, address evolving issues, and connect with an international organization of nurses devoted to the advancement of transplant nursing excellence.
Asian Transplantation Week 2025 (ATW 2025) - November 20-22
Since its international expansion in 2016, ATW has continued to evolve as a leading platform for transplantation professionals across the Asia-Pacific region. Each year, the congress has seen remarkable growth both in scale and in the quality of its scientific content.
This year, under the theme “Together for Innovation: Breaking Boundaries in Asian Transplantation” ATW 2025 is set to offer a dynamic and forward-looking scientific program. It will bring together global experts to share emerging insights, debate pressing challenges, and foster meaningful dialogue across diverse areas of transplantation.
