(Photo) Transplant nurses Katie Stegner, left, and Sara Macedon, center, and transplant surgeon Jayme Locke
This week, Locke and UAB nurses Katie Stegner and Sara Macedon are on their way back to Cape Town to again work with Muller to broaden transplant capabilities. The goal this time is to help Groote Schuur set up a paired exchange program modeled after the UAB Kidney Chain, the world’s longest ongoing transplant chain.
Submitted by Dr Andrea Schlegel, Editorial Fellow, Transplantation.
The Impact of Liver Graft Injury on Cancer Recurrence Posttransplantation.
Li CX, Man K, Lo CM.
Transplantation. 2017 ;101(11):2665-2670.
This review article summarizes the latest findings on the impact of ischemia reperfusion injury and organ quality on tumor recurrence, mainly HCC after liver transplantation (LT). The authors characterize specific risks linked to graft types, eg living donor livers, donation after circulatory death or steatotic grafts. Focus of this review are underlying mechanisms that promote HCC recurrence following LT. The authors provide a very detailed analysis not only on the cellular inflammatory response, involving the microenvironment of the liver, but also on tumor cell migration and invasion promoted by an impaired microcirculation. The review also includes an analysis on the impact of reperfusion injury including hypoxia and angiogenesis on tumor cell aggressiveness. Finally, reactive progenitor cell recruitment and mobilization of other immune cells promoting tumor recurrence in a later phase after LT are highlighted. Overall, the link between reperfusion injury and tumor recurrence is a most relevant clinical problem. Novel preservation strategies in liver transplantation may provide additional relevant insights and treatment options.
UPDATE OF THE INTERNATIONAL INTESTINAL TRANSPLANT REGISTRY AND INTESTINAL TRANSPLANT OUTCOMES
Speaker: Matthew Everly, PharmD, BCPS, FAST, Director, Terasaki Research Institute, Los Angeles, CA, USA
February 21 - The UAE's first full liver transplant from a deceased donor, was performed by a five-person medical and surgery team led by Dr Antonio Pinna, Transplant Surgeon at Cleveland Clinic Abu Dhabi.
February 21 - A combination of machine learning and quantitative computed tomography (CT) could predict the eventual onset of bronchiolitis obliterans syndrome (BOS), also known as popcorn lung, in patients receiving lung transplants, researchers reported in Academic Radiology this week.
February 25 - Laparoscopy allows for a quicker recovery and could get more living donors to come forward.
The Transplantation Society of Australia and New Zealand (TSANZ ) 2018 Annual Scientific Meeting will be held at the Melbourne Convention Centre, Victoria, from 28th April - 1st May, 2018. Featured speakers include TTS members Sandy Feng, Stanley Jordan and Kathryn Tinckam. TSANZ is an affiliated society of TTS.