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Journal Updates

Transplantation Journal - April 2021 - Volume 105 - Issue 4

This month's issue contains an in-depth analysis in three papers on machine learning and artificial intelligence as applied to transplantation. We also have important consensus guidelines from ILTS on clinical trials of machine perfusion as well as recommendations on the problem of veno-occulusive disease after HSCT. A little COVID is still too much - but the data continue to accumulate on its impact in the transplant environments. DCD kidneys and AKI as well as papers on lung transplantation after ECMO explore ways to optimize outcomes from more marginal situations. Uromodulin, Osteopontin, Abatacept, Pro-IL-1, and 17-Estradiol all get consideration.

People in Transplantation

WEEK'S MOST
DOWNLOADED PAPER

Patient Functional Status at Transplant and Its Impact on Posttransplant Survival of Adult Deceased-donor Kidney Recipients
Bui, Kevin; Kilambi, Vikram; Rodrigue, James R.; Mehrotra, Sanjay

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Transplantation Direct

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Donor Club Cell Secretory Protein G38A Polymorphism Is Associated With a Decreased Risk of Primary Graft Dysfunction in the French Cohort in Lung Transplantation

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Upcoming Webinars

ISN-TTS JOINT WEBINAR
Donor/Recipient Pair: Infections

TUESDAY, APRIL 6, 2021
3:00 PM CEST / 9:00 AM EST (MONTREAL TIME)

Open to all healthcare professionals

Speaker: Camille Nelson Kotton, Boston, USA
Moderator: Stephanie Pouch, Atlanta, USA

TTS-WTGF JOINT WEBINAR
COVID Vaccinations for Transplantation

THURSDAY, APRIL 15, 2021
8:00 AM EST (MONTREAL TIME)

Open to all healthcare professionals / Donors / Recipients / Families

Speakers:
Steven Chadban, Paul Harden, Camille Kotton, Michael Ison, Ligia Pierotti

Free to attend

Wednesday, April 7, 2021
2:00PM - 6:00PM (İstanbul Time Zone)

The Middle East Society For Organ Transplantation (MESOT) invites you to a new webinar on How to Increase Organ Donation and Transplantation in Our Region during the Covid-19 Pandemic Period.

With COVID-19 pandemic spreading across the globe since last year, it had the immediate effect of severely reducing living and deceased organ donation and transplantation activity worldwide.

IPTA AHNP - PHTS WEBINAR

April 13, 2021
4:00 PM CET / 11:00 AM EDT (MONTREAL TIME)

Open to all healthcare professionals

IPTA AHNP - PHTS WEBINAR - TUESDAY, APRIL 13, 2021 - 11:00AM EST (MONTREAL TIME)


IPITA 2021 Virtual Congress Announcement

Highlighted News

Boldly Going Where No Science Has Gone Before

It was an amazing experience to touch base once again with Kate Rubins, a NASA astronaut aboard the International Space Station. Connecting via live downlink on March 26, 2021, we discussed how space-based research can enable valuable biomedical advances on our planet. For example, over the past five years, NIH’s National Center for Advancing Translational Sciences has funded a series of tissue chip payloads that have launched to the orbiting laboratory. Rubins, who is a biologist and infectious disease expert, has facilitated three of these projects: Cardinal Heart from Stanford University, Electrical Stimulation of Human Myocytes in Microgravity from the University of Florida, and Cartilage-Bone-Synovium from the Massachusetts Institute of Technology.

Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries

The lung transplant procedure was technically challenging, with severe pleural adhesions, hilar lymphadenopathy, and increased intraoperative ...

Infections with ‘U.K Variant’ B.1.1.7 Have Greater Risk of Mortality

The findings, reported in Nature, come from Nicholas Davies, Karla Diaz-Ordaz, and Ruth Keogh, London School of Hygiene and Tropical Medicine. The London team earlier showed that this new variant is 43 to 90 percent more transmissible than pre-existing variants that had been circulating in England [3]. But in the latest paper, the researchers followed up on conflicting reports about the virulence of B.1.1.7.

Hot off the Press 

«HOT OFF THE PRESS» 
RECENT PUBLICATIONS IDENTIFIED
BY TTS EDUCATION COMMITTEE ON COVID-19

Selected Publications by TTS Education Committee. This week's selection made by Drs. Enver Akalin, Marlies Reinders, and Manisha Sahay..

Kidney Transplant Recipients Rarely Show an Early Antibody Response Following the First COVID-19 Vaccine Administration

Stephanie Yi et al Transplantation2021 Mar 19. doi: 10.1097/TP.0000000000003764.
145 kidney transplant recipients who had received their first COVID-19 vaccine, either the Pfizer-BioNTech or Moderna mRNA-1273, only 6.2% (9) showed an antibody response before the second vaccine administration. Seventy-three percent (8) of these patients had total SARS-CoV-2 IgG antibodies, with 8 developing anti-Spike IgG antibody titers ranging from 1:50 to 1:450. No patients demonstrated anti-SARS-CoV-2 Nucleocapsid IgG antibodies. On the contrary, among the 31 waitlisted ESRD patients who received the first vaccine dose, fully 87% produced an antibody response at the time of the second dose.

Predictors of severe COVID-19 in kidney transplant recipients in the different epidemic waves: analysis of the Spanish Registry

Florentino Villanego et al. Am J Transplant. 2021 Mar 23. doi: 10.1111/ajt.16579.
1011 KT with COVID-19 have been prospectively included in the Spanish Registry and followed until recovery or death. In multivariable analysis, age, pneumonia and KT performed ≤6 months before COVID-19 were predictors of death, whereas gastrointestinal symptoms were protective. Survival analysis showed significant increasing mortality risk in four subgroups according to recipient age and time after KT (age less than 65 years and posttransplant time >6 months, age <65 and time ≤6, age ≥65 and time greater than 6 and age ≥65 and time ≤6): mortality rates were, respectively, 11.3%, 24.5%, 35.4% and 54.5% (p<.001). Patients were significantly younger, presented less pneumonia and received less frequently specific anti-COVID-19 treatment in the second wave (July-December) than in the first one (March-June). Overall mortality was lower in the second wave (15.1 vs. 27.4%, p<.001), but similar in critical patients (66.7% vs. 58.1%, p=.29).

Association between Postmortem Kidney Biopsy Findings and Acute Kidney Injury from Patients with SARS-CoV-2 (COVID-19)

Jesu´s Rivero et al. CJASN 2021 https://doi.org/10.2215/CJN.16281020
85 postmortem kidney biopsies of COVID patients were evaluated. Severe AKI was present in 54%of patients. Biopsy findings included FSGS in 29%, diabetic nephropathy in 27%, and arteriosclerosis in 81%.Acute tubular injury grades 2–3 were observed in 49%. Histopathologic characteristics were not associated with severe AKI; however, pigment casts on the biopsywere associated with significantly lower probability of kidney function recovery.

Weak anti-SARS-CoV-2 antibody response after the first injection of an mRNA COVID-19 vaccine in kidney transplant recipients

Ilies Benotmane et al. Kidney Int 2021 Mar 25;S0085-2538(21)00348-3. doi: 10.1016/j.kint.2021.03.014.
242 kidney transplant recipients received their first COVID-19 vaccine with Moderna mRNA-1273. Only 26 (10.8%) KTRs had a positive serology at 28 days post-injection. The median IgG titer was 224 AU/mL (interquartile range: 76−496 AU/mL), whereas the median IgG titer in the seronegative group was < 6.8 AU/mL.

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