Transplantation June 2021 Issue

JUST RELEASED - TRANSPLANTATION - JUNE ISSUE

This month includes a careful examination of donor-derived cell-free DNA with a meta-analysis, an overview, and a commentary, all of serve to highlight the real progress and separate that from the hype surrounding this biomarker. We publish the next in the series of ILTS consensus statements - on DCD complications. The liver community will also read with interest the analysis of the Liver kidney safety net and also the circumstances where pretransplant bariatric surgery does not impact liver transplant outcomes. The kidney teams continue to combat ABMR and peripheral vascular disease, both of which are reviewed in detail. Teenage adherence and mental health of living kidney donors are also addressed as are many other subjects including heart and lung transplant issues.

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IPITA 2021 Virtual Congress - Abstract Deadline

We invite you to submit your abstract to the IPITA 2021 and be part of an engaging scientific program presenting cutting-edge clinical data and updates on state-of-the-art research.

Key facts you should know:

  • Abstracts will be accepted as either an oral or an e-poster presentation.
  • E-posters will include a 1-minute pitch video showcased in the virtual e-poster lounge.
  • By submitting an abstract, you will have the opportunity to win one of the IPITA 2021 Congress Awards!
  • We are planning a “Best Poster Showdown” session during which presenters of abstracts shortlisted for an award will have the opportunity to interact live with the audience and compete for the “Best Poster Abstract Award”. A total of three “Best Poster Abstract Awards” will be bestowed, one for each of the main congress themes (Pancreas Transplant; Islet Transplant; Stem Cell and Regenerative Medicine).
  • This year we also welcome abstracts under the topic of “COVID, Pancreas and Islet Transplantation and Diabetes”. Top-rated abstracts under this category will be presented during the pre-congress COVID-19 workshop.
  • Accepted abstracts will be published in an online supplement of the Transplantation Journal (subject to author approval).

Starting June 14, Join us for the TTS Masterclass Series

Delivered by the world’s best known and regional experts, each Masterclass includes presentations by an international and a regional expert to bring perspective to the topic, highlight differences and opportunities, and bolster active discussions.

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Hot off the Press 

«HOT OFF THE PRESS» 
RECENT PUBLICATIONS IDENTIFIED
BY TTS EDUCATION COMMITTEE ON COVID-19

Selected Publications by TTS Education Committee. This week's selection made by Drs. Enver Akalin, Marlies Reinders and Millie Samaniego.

SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees

Daryl Geers et al.
Sci Immunol, 2021 May 25;6(59):eabj1750. doi: 10.1126/sciimmunol.abj1750.
This study analyzed humoral and cellular immune responses to wild type SARS-CoV-2 and the B.1.1.7 and B.1.351 variants of concern in a cohort of 121 BNT162b2 mRNA-vaccinated health care workers. This study shows that some variants can partially escape humoral immunity induced by SARS-CoV-2 infection or BNT162b2 vaccination, but S-specific CD4+ T-cell activation is not affected by the mutations in the B.1.1.7 and B.1.351 variants.

Occurrence of severe Covid-19 in vaccinated transplant patients

Sophie Caillard et al.
Kidney International (2021), doi: https://doi.org/10.1016/j.kint.2021.05.011. PMID: 34029554
This study describes a total of 55 solid organ transplant recipients (52 kidney and 3 simultaneous kidney-pancreas) who developed Covid-19 after receiving two doses of mRNA based SARS-CoV-2 vaccines. Nine and forty-six patients received the mRNA-1273 (Moderna) and the BNT162b2 (Pfizer-BioNTech) vaccine, respectively. 15 (27%) required hospitalization for oxygen therapy. Of them, six were admitted to an intensive care unit and three died. Among the 25 patients with available data on anti-SARS-CoV-2 antibodies between the second vaccine dose and the onset of Covid-19 symptoms, 24 had negative serology and one had positive results with weak antibodies levels. Vulnerable immunocompromised patients who are non-responsive to mRNA-based SARSCoV-2 vaccines should undergo close serological follow-up and/or maintain strict sanitary protection measures.

Development of COVID-19 Infection in Transplant Recipients After SARS-CoV-2 Vaccination

Nicole M. Ali et al.
Transplantation2021, May 26. doi: 10.1097/TP.0000000000003836. PMID: 34049360
This is a retrospective chart review of 14 patients who were diagnosed with COVID-19 at a 23.5 days after completion of vaccination series. One patient died, 2 remain hospitalized and 11 are recovered at home. Fifty percent of patients infected required hospitalization for treatment of disease. This study suggests that immunoincompetent populations should continue to practice strict COVID-19 precautions postvaccination.

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