Title: Regeneration of Split Liver on a Pump using Cirrhotic Serum
Mentor: James F. Markmann
Institution: University of Pennsylvania, USA
Title: The Impact of Machine Perfusion on Immune Response and Live Birth Rate after Allogenic Uterus Transplantation
Mentor: Andrea Schlegel
Institution: Cleveland Clinic, USA
Title: Immune Checkpoint Inhibitors in Renal Transplant Patients
Mentor: Alain Le Moine
Institution: Hôpital Erasme, Belgium
Title: Renal Transplantation Ecosystem Assessment in Tanzania, a Mixed Methods Study
Mentor: Francis Furia
Institution: Muhimbili University of Health and Allied Sciences (MUHAS)
Summary: The demand for Renal Replacement Therapy (RRT) is increasing globally. Only 3% of people with End Stage Renal Disease in East Africa receive any RRT. Tanzania's government has made significant efforts in establishing RRT services including nephrology services in the majority of tertiary hospitals and two national renal transplant (RT) programs. Challenges impacting equitable access to RRT services are multifaceted and complex, especially in resource-limited settings. Multidisciplinary team efforts are required for RT programs' sustainability and success. In response, the overall aim of our project is to form a basis for quality research in this area, and using funds from The Transplant Society (TTS) Research Grants we are going to determine the barrier and facilitating factors as well as the capacity to support RT services expansion employing a mixed methods approach.
Title: SAFE-NMP: Safety Assessment For Extended Normothermic Machine Perfusion in Deceased Donor Kidney Transplantation - A Single-Center Pilot Study
Mentor: Ashish Sharma
Institution: Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh INDIA
Summary: The SAFE-NMP pilot study explores the safety and feasibility of extended normothermic machine perfusion (NMP) in preserving deceased donor kidneys prior to transplantation. By enhancing metabolic recovery and reducing preservation injuries, NMP offers benefits like reliable organ viability assessment and improved logistics. This study will compare kidney graft outcomes between extended-NMP and the traditional static cold storage (SCS) and will also assess the optimal period of NMP in deceased donor kidneys.
Title: Use of a Novel Anti-Humoral Therapy - IdeS – as a Desensitization Strategy in Xenotransplantation
Mentor: Andrew B. Adams, MD PhD
Institution: University of Minnesota
Summary: Dr. Matar’s research will focus on strategies to prevent antibody-mediated rejection in xenotransplantation. Specifically, Dr. Matar will study the efficacy of IdeS, an antibody-degrading enzyme with specificity for IgG, as a desensitization strategy in a pig to primate model of kidney xenotransplantation. Dr. Matar will be mentored by Dr. Andrew Adams, MD PhD, currently a Professor of Surgery and chief of the Division of Transplantation at the University of Minnesota.
Applications that do not conform to these guidelines will be returned without review.
Please note, only applicants whose notice of intent is accepted by our peer-review committee will be eligible to submit a full grant application
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