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May 19, 2026

Transplant Related Diagnostics

Making Sense of Viral Loads: PCR Interpretation, Kinetics, and Clinical Application

Tuesday, May 19, 2026 - 10:00 AM (Local time in Montreal)
Local time (Corresponding local time at your current location)
The duration of this presentation is scheduled for 60 minutes.

Overview

Accurate interpretation of viral load testing is central to the management of transplant recipients, yet significant variability in reporting units, assay platforms, and specimen types continues to create confusion in clinical practice. This webinar will provide a practical, case-based approach to interpreting real-time PCR results for common post-transplant viral infections, including CMV, BK virus, and EBV.


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Participants will gain a clearer understanding of how to interpret viral loads reported in IU/mL versus log values, and why logarithmic expression may better reflect clinically meaningful changes. The session will explore the clinical significance of low-level viremia, including how to distinguish true signal from assay variability, and will review expected viral kinetics and optimal monitoring intervals.

In addition, the webinar will address key challenges in standardization, including differences across testing platforms (e.g., amplicon size), specimen types (whole blood vs plasma), and conversion between copies/mL and IU/mL—highlighting practical implications for BK virus monitoring. Principles of diagnostic stewardship will be emphasized to support appropriate test utilization and interpretation. Finally, speakers will discuss when to suspect antiviral resistance in CMV infection and when resistance testing should be pursued.

This session is designed to equip transplant clinicians and laboratory professionals with the tools needed to translate viral load data into confident, evidence-based clinical decisions.



Objectives

  • Interpret viral load results across reporting formats (IU/mL, copies/mL, and log values) and apply this understanding to clinical decision-making in CMV, BK virus, and EBV.
  • Evaluate the clinical significance of viral load results, including low-level viremia, viral kinetics, and appropriate monitoring intervals in transplant patients.
  • Recognize key sources of variability and apply diagnostic stewardship principles, including differences across assay platforms, specimen types, and when to pursue additional testing (e.g., CMV resistance testing).

Supporting Materials


TTS Education Chair
Camille N. Kotton, United States 
Co-Host
Bio
TTS Councilor - North America
Atul Humar, Canada  
Co-Host
Bio
Hans H. Hirsch, Switzerland 
Co-Host
Bio

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Contact

Staff Directory
+1-514-874-1717
info@tts.org

Address

The Transplantation Society
International Headquarters
740 Notre-Dame Ouest
Suite 1245
Montréal, QC, H3C 3X6
Canada

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