Presenter: Emily and Camille, Blumberg and Kotton, Philadelphia, United States Authors: Emily Blumberg, Philadelphia, PA, USA and Camille N. Kotton, Boston, MA, USA
Val-GCV in liver transplants – Pro And Cons
Emily Blumberg, Philadelphia, PA, USA
Camille N. Kotton, Boston, MA, USA
Prevention of CMV improves outcomes after liver transplant. Both pre-emptive therapy and prophylaxis are established modalities of prevention. In the initial PV16000 study comparing valganciclovir with oral ganciclovir (Paya et al, AJT 2004), liver transplant patients on valganciclovir had higher rates of tissue invasive disease, and the US FDA did not approve valganciclovir for use in this population. It was approved for use in other regions of the world, including the EU and Canada. In a survey of transplant clinicians, the majority use valganciclovir for prophylaxis. While some studies show inferior outcomes with valganciclovir, others show no inferiority. We will review recent data regarding the use of valganciclovir in liver transplant recipients.
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