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Efecto del precondicionamiento isquemico en modelos experimentales microquirurgicos de isquemia–reperfusion intestinal / Effect of Ischemic Preconditioning in Experimental-Microsurgical Models of Intestinal Ischemia-Reperfusion

62.1 - Efecto del precondicionamiento isquemico en modelos experimentales microquirurgicos de isquemia–reperfusion intestinal / Effect of Ischemic Preconditioning in Experimental-Microsurgical Models of Intestinal Ischemia-Reperfusion

Presenter: Pablo, Stringa, La Plata, Argentina
Authors: Pablo Stringa

Overview:

La injuria por isquemia reperfusión (IIR) es una reacción inflamatoria con alta morbi-mortalidad en pacientes sometidos a trasplante intestinal o que sufren diversas enfermedades intestinales. Pese a que se postulan varias estrategias para atenuar la IIR, no existe consenso sobre cuál es la más adecuada. Entre ellas, el Precondicionamiento isquémico aparece como un tratamiento promisorio capaz de disminuir la IIR y por tal motivo es objeto de estudio.

Ischemia-reperfusion injury (IRI) is an inflammatory reaction with high morbidity and mortality in patients undergoing intestinal transplantation or suffering from intestinal diseases. Therefore, establishing strategies to mitigate IRI are major objectives in surgical fields including transplantation. Ischemic preconditioning appears as a promising treatment able to decrease IIR. For this reason it is the object of our study.


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