Multidrug resistant bacteria in solid organ transplant recipients
3.2 - Optimising anti-bacterial therapy; do we underdose and set the scene for resistance?
Presenter: Jason, Roberts, Brisbane, Australia Authors: Jason Roberts
Transplant patients, like trauma, burns and critically ill patients, can develop dramatically altered pharmacokinetics (antibacterial concentrations) leading to altered pharmacodynamics (antibacterial effects, e.g. bacterial killing). Part of these altered effects may be sub-optimal rates of bacterial eradication which can predispose to the development of sub-populations of resistant pathogens leading to greater patient morbidity and potentially mortality. Minimising the emergence of antibiotic resistance may be achieved through optimized antibacterial therapy. In this presentation, the issues surrounding the emergence of resistance associated with sub-optimal dosing will be discussed as well as some key points related to optimizing dosing of specific antibiotic agents.
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