Transplant tourism, travel with the intent of receiving or donating a transplanted organ, is increasing but not without risks. Unfortunately, many of these procedures are not recorded in databases and the incidence of complication is unknown. The transplant tourism is often associated with a worse outcome, early rejection, graft loss and a higher rate of infection and death. Vaccination before undergoing immunossupression is indicated and the evaluation of serologic response may help. Pretransplant evaluation of the donor/recipient is variable and the quality of screening tests may be substandard. Health-care associated infections are frequent, patients may be colonized or infected with multi-resistant bacteria. Some transplant-associated infections are geografically restricted and the source of infection can be the transplanted organ or transfused blood. These infections may appear early or late after the procedure. Optimizing their posttransplant prophylaxis, obtaining information about possible donor-derived infection and immunosuppresion is advisable. Re-screen the patient for blood-borne and some endemic pathogens (if there is an epidemiological risk) may also aid in early recognition of infection providing efficacious therapy.