Official Sections CTRMS ISVCA IPITA IPTA ISODP IRTA IXA SPLIT TID

2018 - Online Interactive Update Course (en, sp, pt)


This page contains exclusive content for the member of the following sections: TTS, CTS, IPITA, ISODP, IXA, ITA, TID, IHCTAS, IPTA, SPLIT

Rejection Pathology

3.2 - Tolerance: What Is It and How Do We Achieve It?

Presenter: Leonardo V., Riella, , United States
Authors: Leonardo V. Riella

[en] This module focuses on the most relevant aspects of the advances in rejection pathology. 

Rejection pathology has undergone big changes during the last years, while reconsidering the antibody-mediated rejection, the interpretation of cell phenomena and the associated humoral responses. New roles and processes are being discovered about tolerance and chimerism.

The processes resulting in damage and those determined by tolerance are always present, strongly interacting with the relationship of the recipient and the donor immune systems with the graft. They explain the spontaneous evolution, the minimum treatment to the transplanted organs, and contribute to the planning of treatments to increase life expectancy.


[sp] Este módulo está centrado en los aspectos más relevantes de los avances en el conocimiento de la patogenia del rechazo.

Éste ha tenido grandes cambios en los últimos años, en la re-consideración de los fenómenos mediados por anticuerpos, la interpretación de los fenómenos celulares y su intrincamiento con los humorales. Nuevos protagonistas y procesos se están descubriendo sobre tolerancia y quimerismo.

Tanto los procesos que desembocan en daño como aquellos que determinan tolerancia están siempre presentes, en intensa interacción, en la relación del sistema inmune de receptor y donante y el injerto. Explican la evolución espontánea y bajo tratamiento de los órganos trasplantados y contribuyen a diseñar tratamientos para prolongar su vida.


[pt] Este módulo está centrado nos aspectos mais relevantes dos avanços do conhecimento sobre a patogenia da rejeição.

Este módulo está centrado nos aspectos mais relevantes dos avanços do conhecimento sobre a patogenia da rejeição.

Nesse tópico, houve grandes mudanças nos últimos anos, visando a reavaliação dos fenômenos mediados por anticorpos, a interpretação dos fenômenos celulares e seu envolvimento com os fenômenos humorais. Novos protagonistas e processos relativos à tolerância e o quimerismo vêm sendo descobertos.

Tanto os processos que desembocam em uma lesão como aqueles que determinam tolerância estão sempre presentes, com interação intensa, na relação entre os sistemas imunes do receptor e do doador e o enxerto. Explicam a evolução espontânea e sob tratamento dos órgãos transplantados, e contribuem para o desenho de tratamentos que buscam prolongar sua vida.

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