2011 - 10th Meeting - IHCTAS

This page contains exclusive content for the member of the following sections: TTS, IHCTAS

Plenary Session II. Part 2: Infectious Disease Session

4.3 - Risk of Donor Disease Transmission in Transplantation

Presenter: Matthew J., Kuehnert, Atlanta, GA, USA
Authors: Matthew J. Kuehnert

Risk of Donor Disease Transmission in Transplantation

Matthew J. Kuehnert, Center for Diseases Control and Prevention, Atlanta, GA, USA.

This presentation will include review of recent transmissions through organ transplantation and lessons learned, including transmission from deceased and living donors; preliminary results of a study which estimates the yield of nucleic acid testing (NAT) for organ donor screening; plans to revise the current Public Health Service (PHS) Guidelines for reducing HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) through solid organ transplantation; and identification of knowledge gaps in organ transplant safety, highlighting the need for prospective data collection to improve risk estimates and inform the effectiveness of current policies. Donors should be risk managed from the standpoint of disease transmission to provide the best possible benefit for recipients. This process includes the use of an organ donor screening through epidemiologic and laboratory methods, and recipient informed consent and post-transplant testing.

A standardized and transparent donor screening and recipient evaluation process is particularly critical for relatively new life-enhancing procedures, such as vascularized composite allografts. PHS Guidelines are being revised to assess donor risk through these methods and appropriate recipient evaluation, including the use of NAT. However, there are also research gaps, including the need for better models to estimate risks of false positive tests and other threats to optimal organ placement. Structured databases on donor and recipient results are key, allowing for development of the best risk communication and informed consent.

Important Disclaimer

By viewing the material on this site you understand and accept that:

  1. The opinions and statements expressed on this site reflect the views of the author or authors and do not necessarily reflect those of The Transplantation Society and/or its Sections.
  2. The hosting of material on The Transplantation Society site does not signify endorsement of this material by The Transplantation Society and/or its Sections.
  3. The material is solely for educational purposes for qualified health care professionals.
  4. The Transplantation Society and/or its Sections are not liable for any decision made or action taken based on the information contained in the material on this site.
  5. The information cannot be used as a substitute for professional care.
  6. The information does not represent a standard of care.
  7. No physician-patient relationship is being established.



Staff Directory
This email address is being protected from spambots. You need JavaScript enabled to view it.


The Transplantation Society
International Headquarters
505 Boulevard René-Lévesque Ouest
Suite 1401
Montréal, QC, H2Z 1Y7