2011 - BSS 2011 Symposium

This page contains exclusive content for the member of the following sections: TTS

Plenary Session 3: Emerging Issues in Transplantation: Composite Tissue Transplantation and Immunosenescence

7.1 - Aging and its Impact on Effector and Memory Cells

Presenter: Susan L., Swain, Worcester, United States
Authors: Susan L. Swain

Aging and it’s Impact on Effector and Memory Cells

Susan L. Swain, Department of Pathology, University of Massachusetts Medical School 

Our studies over the past few years have given us new insights into the diversity of immune mechanisms that memory cells have at their disposal to attack pathogens, that could in other circumstances be directed against transplants. We find that even what appears to be a fairly homogeneous Th1 effector population, gives rise to memory cells that when restimulated carry out a broad array of functions at distinct times and in different locations. Within 2 days, restimulation of memory CD4 T cells leads to an enhanced innate inflammatory response in lung and other sites. Before 5 days the responding cells have helped naïve B cells to ensure a more rapid and effective antibody response via a cognate interaction occurring in peripheral lymphoid organs. During this same timeframe the CD4 memory response enhances the response of CD8 naïve T cells through less well-characterized pathways.  The memory cells in the periphery also expand and differentiate into secondary (20) effectors with kinetics only slightly faster than those of 10 effectors generation. These migrate to the lung by day 6 or so and participate in direct viral clearance via multiple mechanisms including cytotoxicity and IFNg-dependent effects. These multiple activities occurring in different sites can synergize and are able to provide very strong protection against influenza. Because memory cells respond at low antigen dose and require less costimulation than naïve cells, they clearly can present a formidable barrier to transplantation.

Important Disclaimer

By viewing the material on this site you understand and accept that:

  1. The opinions and statements expressed on this site reflect the views of the author or authors and do not necessarily reflect those of The Transplantation Society and/or its Sections.
  2. The hosting of material on The Transplantation Society site does not signify endorsement of this material by The Transplantation Society and/or its Sections.
  3. The material is solely for educational purposes for qualified health care professionals.
  4. The Transplantation Society and/or its Sections are not liable for any decision made or action taken based on the information contained in the material on this site.
  5. The information cannot be used as a substitute for professional care.
  6. The information does not represent a standard of care.
  7. No physician-patient relationship is being established.



Staff Directory
This email address is being protected from spambots. You need JavaScript enabled to view it.


The Transplantation Society
International Headquarters
505 Boulevard René-Lévesque Ouest
Suite 1401
Montréal, QC, H2Z 1Y7