P-281

Vitamin D receptor genotype and pancreas allograft

N. Azarpira, S. Nikeghbalian, B. Geramizadeh, M. Aghdai, M. Darai, M. Rahsaz
Transplant Research Center, Shiraz, Iran

Objective: Transplantation of pancreasgrafts is an established treatment for diabetes mellitus. Polymorphisms ingenes, coding for proteins involved in immune response, may influenceimmunological and non- immunological mechanisms that lead to allograft loss.Vitamin D receptor (VDR) agonist has been shown to reduce short and long termallograft rejection in animal model. There are functional polymorphisms in VDRgene.

Material and Methods: A totalof 20 pancreatic recipients with at least 2 years follow-up were selected and genotyped for polymorphismin the VDR genes (FokI) and the association of each genotype with acuterejection was evaluated.

Results and conclusion: Among them 14 recipients with FF and 6 patientswith Ff genotype were identified. Six patients had documented rejection episode.We are unable to find statistically significant association between study polymorphism and clinical outcomes.

P-281

Vitamin D receptor genotype and pancreas allograft

N. Azarpira, S. Nikeghbalian, B. Geramizadeh, M. Aghdai, M. Darai, M. Rahsaz
Transplant Research Center, Shiraz, Iran

Objective: Transplantation of pancreasgrafts is an established treatment for diabetes mellitus. Polymorphisms ingenes, coding for proteins involved in immune response, may influenceimmunological and non- immunological mechanisms that lead to allograft loss.Vitamin D receptor (VDR) agonist has been shown to reduce short and long termallograft rejection in animal model. There are functional polymorphisms in VDRgene.

Material and Methods: A totalof 20 pancreatic recipients with at least 2 years follow-up were selected and genotyped for polymorphismin the VDR genes (FokI) and the association of each genotype with acuterejection was evaluated.

Results and conclusion: Among them 14 recipients with FF and 6 patientswith Ff genotype were identified. Six patients had documented rejection episode.We are unable to find statistically significant association between study polymorphism and clinical outcomes.