This page contains exclusive content for the member of the following sections: TTS, CTS, IPITA, ISODP, IXA, ITA, TID, IHCTAS, IPTA. Log in to view.

Experimental Models

171.1 - Experimental Models

Presenter: Julie, Kerr-Conte, Lille, France
Authors: Julie Kerr-Conte


What experimental model(s) should we use to assess human islet quality in vivo? diabetic or nondiabetic immunodeficient mice? How many islets per mouse? 

Are there any differences in islet function/implantation between the immunodeficient mouse strains? Should we use Matrigel?

What about using rodent islets for research on human diabetes1?

Should we use large animal models? Why? What teams have and what species have they used?

Are we using the right human islet donors for transplantation (age, BMI, HbAlc)? Experimental models to test the capacity of human islets to adapt to their environment?

1. Of rodents and men: species-specific glucose regulation and type 2 diabetes research PC Chandrasekera & J Pippin 2013.


Julie Kerr-Conte received her BS in Biology from SUNY Albany and her Masters in Physiological Chemistry from the University of Winsconsin. In 1990 under the leadership of Dr. Karim Boudjema, she assisted in setting up a transplantation center in Strasboug. She then went on to earn her PhD in Health Sciences at the Science and Technology University in Lille. In 2005 she earned HDR in Biology at the University of Lille where she currently is Professor of cell therapy/cell biology in the Medical Faculty. She also serves as Deputy Director of INSERM in the translational research of diabetes.

Important Disclaimer

By viewing the material on this site you understand and accept that:

  1. The opinions and statements expressed on this site reflect the views of the author or authors and do not necessarily reflect those of The Transplantation Society and/or its Sections.
  2. The hosting of material on The Transplantation Society site does not signify endorsement of this material by The Transplantation Society and/or its Sections.
  3. The material is solely for educational purposes for qualified health care professionals.
  4. The Transplantation Society and/or its Sections are not liable for any decision made or action taken based on the information contained in the material on this site.
  5. The information cannot be used as a substitute for professional care.
  6. The information does not represent a standard of care.
  7. No physician-patient relationship is being established.



Staff Directory


The Transplantation Society
International Headquarters
740 Notre-Dame Ouest
Suite 1245
Montréal, QC, H3C 3X6