109.1 - Experimental Models
Presenter: Julie, Kerr-Conte, Lille, France
Authors: Julie Kerr-Conte
What experimental model(s) should we use to assess human islet quality in vivo? diabetic or nondiabetic immunodeficient mice? How many islets per mouse?
Are there any differences in islet function/implantation between the immunodeficient mouse strains? Should we use Matrigel?
What about using rodent islets for research on human diabetes1?
Should we use large animal models? Why? What teams have and what species have they used?
Are we using the right human islet donors for transplantation (age, BMI, HbAlc)? Experimental models to test the capacity of human islets to adapt to their environment?
1. Of rodents and men: species-specific glucose regulation and type 2 diabetes research PC Chandrasekera & J Pippin 2013.
Julie Kerr-Conte received her BS in Biology from SUNY Albany and her Masters in Physiological Chemistry from the University of Winsconsin. In 1990 under the leadership of Dr. Karim Boudjema, she assisted in setting up a transplantation center in Strasboug. She then went on to earn her PhD in Health Sciences at the Science and Technology University in Lille. In 2005 she earned HDR in Biology at the University of Lille where she currently is Professor of cell therapy/cell biology in the Medical Faculty. She also serves as Deputy Director of INSERM in the translational research of diabetes.
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