GFR Assessment of Living Kidney Donors CandidatesLiving kidney donation provides the best outcomes (survival, cost, and quality of life) of all renal replacement modalities. Living kidney donors, on the other hand, are at an increased risk of end-stage kidney disease (ESKD) after donation compared with healthy nondonors for multiple reasons. Extensive pre-donation screening is required to assess eligibility for donation to avoid the rejection of suitable candidates and minimize the acceptance of donors with an increased risk of ESKD.
Heart Transplantation, Either Alone or Combined With Liver and Kidney, a Viable Treatment Option for Selected Patients With Severe Cardiac AmyloidosisHeart transplantation in cardiac amyloidosis (CA) patients is possible and generally considered for transplantation if other organs are not affected. In this study, we aimed to describe and assess outcomes in patients following heart transplantations at our CA referral center.
The project, funded by charity Kidney Research UK, could increase the supply of kidneys available for transplant, particularly within ethnic minority groups who are less likely to be a match for the majority of donated kidneys.
Professor Mike Nicholson and PhD student Serena MacMillan used a normothermic perfusion machine – a device which connects with a human kidney to pass oxygenated blood through the organ to better preserve it for future use – to flush blood infused with an enzyme through the deceased kidney.
The enzyme acted like “molecular scissors” to remove the blood type markers that line the blood vessels of the kidney resulting in the organ being converted to the most common O type.
A kidney from someone with an A blood type cannot be transplanted to someone with a B blood type, nor the other way around. But changing the blood type to the universal O will allow more transplants to take place as O can be used for people with any blood group.
|Session 1: Qualifying a composite surrogate for long-term graft loss after kidney transplantation
|Session 2: RWE use in transplant clinical trials
|Session 3: Future endpoints in kidney transplantation
This survey focuses on issues encountered by physicians in day-to-day decision-making.
Your responses will aid TTS in developing strategies, programs and resources to improve access and transparency in transplantation, emphasizing increasing deceased donor organ transplantation.
The information collected will also aid the work TTS is doing as part of our World Health Organization collaboration.
All responses will be kept confidential and anonymous.