Transplantation Updates

Just Released - Transplantation - January 2023 Issue

A year after we published the first definitive evidence of the failures of two doses of covid vaccine, we now publish the results of another year's experience both with the disease and its evolution, and also the response of multiple vaccine doses in our patients. Elsewhere there is a focus on what various minimally invasive techniques can and can't tell us - a definitive review of the molecular microscope for the heart and some caution on ddcfDNA as well as a nice review of the current realities and potential for such markers. Regulator T cells are subject of some interesting research papers and we have the definitive overview of innate B cell function in alloreactivity. There is much for everyone as we start the new year: from lung to heart, liver to kidney, VCA to islets.

Table of Contents

In View

Around the World
| Gender Disparity in Asian-Pacific Countries: An Analysis of the ASTREG-WIT-KT Registry

Research Highlights
| Research Highlights

Game Changer
| A First Step Toward a Cross-tissue Atlas of Immune Cells in Humans

Special Article
| Registry of the International Society of Uterus Transplantation: First Report

Expert Insight
| Lung Transplantation for COVID-19–related Lung Disease: Clinical Experience and Call for a Global Registry


| COVID-19 Vaccines and Solid Organ Transplantation: More Doses, More Protection
| The Potential Clinical Application of Induced Tolerogenic Macrophages
| Donor-derived Cell-free DNA Measurement in Kidney Transplant Patients Without Allograft Dysfunction: More Evidence and More Questions
| Understanding Current Limitations to Exercise Interventions After Liver Transplantation


| The Molecular Microscope Diagnostic System: Assessment of Rejection and Injury in Heart Transplant Biopsies
| Diagnostic Potential of Minimally Invasive Biomarkers: A Biopsy-centered Viewpoint From the Banff Minimally Invasive Diagnostics Working Group
| Mammalian Target of Rapamycin Inhibitors and Kidney Function After Thoracic Transplantation: A Systematic Review and Recommendations for Management of Lung Transplant Recipients
| Do Treg Speed Up with CARs? Chimeric Antigen Receptor Treg Engineered to Induce Transplant Tolerance
| Regulatory T Cells: Liquid and Living Precision Medicine for the Future of VCA
| Beyond Adaptive Alloreactivity: Contribution of Innate B Cells to Allograft Inflammation and Rejection
| Diagnostic and Therapeutic Implications of Ex Vivo Lung Perfusion in Lung Transplantation: Potential Benefits and Inherent Limitations

Original Basic Science

| A Prevascularized Sinus Tract on the Liver Surface for Islet Transplantation
| CCAAT/Enhancer-binding Protein Homologous Protein Promotes ROS-mediated Liver Ischemia and Reperfusion Injury by Inhibiting Mitophagy in Hepatocytes
| Lymph Node Fibroblastic Reticular Cells Attenuate Immune Responses Through Induction of Tolerogenic Macrophages at Early Stage of Transplantation
| Clamping of the Aortic Arch Vessels During Normothermic Regional Perfusion Does Not Negatively Affect Donor Cardiac Function in Donation After Circulatory Death

Original Clinical Science—Liver

| Outcomes of Sorafenib for Recurrent Hepatocellular Carcinoma After Liver Transplantation in the Era of Combined and Sequential Treatments
| Impact of Older Donor Age on Recipient and Graft Survival After LDLT: The US Experience
| Urgent Liver Transplantation for Acute Liver Failure in Pregnant Women: The Optimum Timing for Delivery
| Does Exercise Training Improve Physical Fitness and Health in Adult Liver Transplant Recipients? A Systematic Review and Meta-analysis

Original Clinical Science—General

| PASC in Solid Organ Transplant Recipients With Self-reported SARS-CoV-2 Infection
| Humoral Response to the Fourth BNT162b2 Vaccination and Link Between the Fourth Dose, Omicron Infection, and Disease Severity in Renal Transplant Recipients
| Real-world Evidence of COVID-19 Vaccines Effectiveness in Solid-organ Transplant Recipient Population in Colombia: A Study Nested in the Esperanza Cohort
| Splenic Vessels as a Rescue for Pediatric Kidney Retransplantation in Children With Iliac-caval Agenesis or Thrombosis
| Seeking Standardized Definitions for HLA-incompatible Kidney Transplants: A Systematic Review
| Clinical Outcomes and Risk Factors for Carbapenem-resistant Enterobacterales Bloodstream Infection in Solid Organ Transplant Recipients
| Prediction of Renal Function in Living Kidney Donors and Recipients of Living Donor Kidneys Using Quantitative Histology
| An Assessment of the Value of Donor-derived Cell-free DNA Surveillance in Patients With Preserved Kidney Allograft Function
| Can the Area Under the Curve/Trough Level Ratio Be Used to Optimize Tacrolimus Individual Dose Adjustment?

Letters to the Editor

| RE: Imlifidase-generated Single-cleaved IgG: Implications for Transplantation
| Laparoscopic Sleeve Gastrectomy for Obesity After Combined Liver-intestinal Transplantation: A Case Report
| Psoriasis Flare in a Liver Transplant Patient: A Case Report of a Successful Treatment With Apremilast
| Single-center Experience on Nonlung Solid Organ Transplantation From SARS-CoV-2–positive Donors


| Antibody-mediated Rejection Without Detectable Donor-specific Antibody Releases Donor-derived Cell-free DNA: Results From the Trifecta Study: Erratum
| Four Decades of Clinical Liver Transplantation Research: Results of a Comprehensive Bibliometric Analysis: Erratum

Just Released - Transplantation Direct - December 2022 Issue

We end the 2022 Transplantation Direct publication year by presenting a wide range of exciting research. In kidney transplantation, early posttransplant studies on signs of IFTA and on delayed graft function (DGF) related to use of balanced low chloride crystalloid solutions and to DGF severity stratification at discharge are investigated; longer-term outcomes are investigated in relation to living donor psychosocial evaluations and eHealth experiences, and the effects of Clazakizumab on biomarkers in patients with ABMR are tested . For liver, we have articles looking at MELD-era impact concerning portopulmonary hypertension and transplantation for Budd-Chiari Syndrome; also, hepatitis E infection issues are studied in an endemic region, a case study/literature review on hilar amputation neuroma in liver transplantation is presented, length of stay impact is examined in simultaneous liver-kidney transplant recipients, and there is a cutting edge assessment of hyperspectral imaging of machine perfused allografts. In pediatrics, a case series looks at treatment strategies in ABO incompatible liver recipients. For lung transplanters, “long-term" dd-cfDNA levels are examined in allograft recipients. In the realm of pancreas transplantation, studies are presented on induction therapy selection in older SPK recipients, and in pancreas alone recipients; also, one group investigates outcomes in older recipients receiving a SPK transplants. For all the details via open access, please visit our Transplantation Direct website.

Table of Contents

Kidney Transplantation

Liver Transplantation

Lung Transplantation

Pancreas and Islet Transplantation

Infectious Disease

Transplantation - Highlighted Articles

“Creating Blue Skies Overhead for All” Introduction of the 2022 Recipient of the Medawar Prize of the Transplantation Society: Professor Jeremy Chapman

The Medawar Prize was designed to honor Sir Peter Medawar for his contributions to transplantation research. His most notable work was the discovery of acquired immune tolerance, for which he was awarded the Nobel Prize in 1960 shared with Sir Frank Macfarlane Burnet.

Paired Exchange Living Donor Liver Transplantation: A Nine-year Experience From North India

Paired exchange liver transplantation is an evolving strategy to overcome ABO blood group incompatibility and other barriers such as inadequate graft-to-recipient weight ratio and low remnant liver volume in donors. However, for the transplant team to carry 4 major operations simultaneously is a Herculean effort. We analyzed our experience with liver paired exchange (LPE) program over the past 9 y.

Transplantation Direct - Highlighted Tweet

Relationship of Exercise Capacity, Physical Function, and Frailty Measures With Clinical Outcomes and Healthcare Utilization in Lung Transplantation: A Scoping Review

Measures of exercise capacity, frailty, and physical function are commonly used in lung transplant candidates and recipients to evaluate their physical limitations and the effects of exercise training and to select candidates for transplantation. It is unclear how these measures are related to clinical outcomes and healthcare utilization before and after lung transplantation. The purpose of this scoping review was to describe how measures of exercise capacity, physical function, and frailty are related to pre- and posttransplant outcomes.

TTS-ILTS Paired Transplant Centers Program - Apply Today!

Program Schedule

Deadline to Apply: January 1, 2023
Program Start Date: April 1, 2023

An experienced supporting transplant center (SC) in the developed world is paired with an emerging transplant center (EC) to facilitate vital multidisciplinary training and an exchange of knowledge and expertise.
The project aims to benefit both centers. The SC is involvedin global health, and promotes ethical and competent transplantation in regions of the world with limited or no current access to transplantation. The EC connects with a multidisciplinary team of experts in transplantation from a world-leading center.
The ultimate goal is for Level 3 centers to graduate and become true local centers of excellence for regional training and support.
The TTS-ILTS Paired Transplant Centers Program is bound by a limited budget which it cannot exceed. This budget is divided over all center pairs who receive a different financial allocation dependent on their level within the program.
  • Level 1 - maximum annual allocation per pair: $ 3,500 USD
  • Level 2 - maximum annual allocation per pair: $12,000 USD
  • Level 3 - maximum annual allocation per pair: $15,000 USD
Programs Launched in April 2022
Dow Universtiy Hospital, Karachi, Pakistan paired with the University of Chicago, Chicago, USA

TTS and ILTS congratulates these teams and wishes them every success in their collaborations over the next six years and beyond.

Recent Paired Centers Site Visit

Dr. Shams-Ud-Din as part of the TTS-ILTS Paired Transplant Centers Program travelled to UCSF. His trip's purpose was to interact with the UCSF Organ transplant team, to see their protocols of pre and post transplant Patient management, to see deceased donor organ transplantation, organ procurement and normothermic perfusion dynamics and implications.

International Transplantation Science (ITS) Meeting

ITS 2023 will be held in Niagara-on-the-Lake, Ontario, Canada from April 30th to May 3rd, 2023. The meeting is intended to stimulate in-depth, cutting-edge discussions from leading experts addressing challenges that arise from connecting basic fundamental to translational science in transplantation.

Abstract Deadline: December 20, 2022

IPTA 2023 - Extended Early-Bird Registration Deadline

Join us in Austin, Texas, March 25-28, 2023, for the 12th Congress of the International Pediatric Transplant Association!

Early-Bird Registration Extended Deadline: January 15, 2023

Latest Recordings

SPLIT is running a "4th Year Fellow Series" which includes talks on advanced hepatology and pediatric transplantation topics aimed to increase the knowledge of 4th year liver transplant fellows globally.

The series is open to SPLIT Fellows only however all TTS and SPLIT members may view the recordings!

Highlighted Upcoming Events

Mark your calendars for the 2023 World Congress of Nephrology. WCN’23 will host thousands of participants, including the world’s leading experts in kidney health, to exchange the latest science and clinical applications to improve kidney care and prevent kidney disease worldwide. WCN’23 will be jointly organized alongside the 21st Asian Pacific Congress of Nephrology (APCN’23). Hosted by the Nephrology Society of Thailand (NST) and the Asian Pacific Society of Nephrology (APSN), the ISN is pleased to bring WCN’23 to South-East Asia to help advance understanding and awareness of kidney diseases in the region

Survey - Using Social Media to Promote Cutting-Edge Research in Transplantation


Researchers from NYU Langone Health are conducting a research study titled Using Social Media to Promote Cutting-Edge Research in Transplantation. Dr. Macey Levan from the Departments of Surgery and Population Health at NYU Langone Health is the Principal Investigator leading this research. The purpose of this study is to learn how members of the Transplantation community use social media for professional purposes and how they see themselves using it in the future.

You qualify to complete this study if you fall under one of the following categories:

  • Subscribers to the weekly email of new published articles in the Transplantation or Transplantation Direct journals 
  • Have submitted an article to the Transplantation or Transplantation Direct journals in the past 5 years
  • Member of The Transplantation Society (TTS)
  • Subscribers to newsletters from the TTS (Quarterly - Tribune, Weekly - Tribune Pulse)

Participation in this study is voluntary and will consist of completing an online survey about your thoughts on how you use social media for professional purposes and how you see yourself using it in the future. It will take about 5 minutes of your time.

If you are interested in participating, please click the link below to complete the survey: 

If you have any questions or concerns about this study, please contact Dr. Levan at

This study has been reviewed by the NYU Langone Health Institutional Review Board (Study Number: 22-00681).


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