TTS Strategic Retreat - January 9-11, 2023

The Transplantation Society (TTS) recently held a strategic retreat in Cape Town, South Africa from January 8-11, 2023. The retreat began with a Transplantation journals retreat facilitated by Editor-in-Chief, Jeremy Chapman, followed by a three-day TTS Council retreat led by President, Elmi Muller. The interactive sessions were intense but rewarding, encouraging divergent thinking and exploration of new possibilities and areas of interest for the society and the field. The Executive Committee is reviewing the outcomes of the meeting and gathering additional feedback to draft a new strategic plan to shape the future of TTS. Stay tuned for updates!

IPITA/HSCI/JDRF Summit - Abstract Submission Open

The Program Committee is pleased to announce that abstract submission for the 4th IPITA/HSCI/JDRF Summit on Stem Cell Derived Beta Cells is open!

Please keep note of the following important deadlines:

  • January 12, 2023 | Abstract Submission Opens
  • January 27, 2023 | Abstract Submission Deadline
  • February 24, 2023 | Notification Letters Sent
Submission Topics
  • Stem cell-derived islets
  • Genome editing
  • Encapsulation
  • Islet Development
  • Clinical Trials
  • Off-target cells/safety considerations
  • Biomanufacturing
  • Ethics

Transplantation Updates

Transplantation - Highlighted Tweets

Kidney transplant recipients undergo lifelong monitoring of allograft function and evaluation for transplant complications. The current monitoring paradigm utilizes blood, urine, and tissue markers that are insensitive, nonspecific, or invasive to obtain. As a result, problems are detected late, after significant damage has accrued, and often beyond the time at which complete resolution is possible.

We studied the variation in molecular T cell–mediated rejection (TCMR) activity in kidney transplant indication biopsies and its relationship with histologic lesions (particularly tubulitis and atrophy-fibrosis) and time posttransplant.

Transplantation Direct - Highlighted Tweets

Delayed graft function (DGF) is a major complication of deceased donor kidney transplantation. Saline (0.9% sodium chloride) is a commonly used intravenous fluid in transplantation but may increase the risk of DGF because of its high chloride content. Better Evidence for Selecting Transplant Fluids (BEST-Fluids), a pragmatic, registry-based, double-blind, randomized trial, sought to determine whether using a balanced low-chloride crystalloid solution (Plasma-Lyte 148) instead of saline would reduce DGF. We sought to evaluate the generalizability of the trial cohort by reporting the baseline characteristics and representativeness of the trial participants in detail.

Pretreating porcine kidneys with Corline Heparin Conjugate (CHC) during hypothermic machine perfusion (HMP) has been shown to reduce preservation injury and improve early kidney function. In this first-in-human phase I study, the safety and tolerability of transplanting CHC-pretreated kidneys were evaluated.

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