The March issue of Transplantation Direct is online and open for everyone. Several articles on immunosuppression in kidney transplantation offer insight on long-term outcomes using prolonged-release tacrolimus, Belatacept dosing every 2 months vs 1 month (an RCT), immunosuppression adherence in Japan, and fasting status and circadian variation with MMF and the glucoronate metabolite. Additionally, there is a report on first-in-human use of a novel thermal barrier bag during kidney transplantation. On the topic of liver transplantation, we have articles on the use of an anticoagulation stratification algorithm and on the role of pretransplant infections in pediatric LDLT recipients. For the cardiologists, a study looks at the influence of tricuspid regurgitation after heart transplantation and another tests ex vivo heart perfusion in the US to push the distance to transplant center boundaries. This issue also features articles on organ donation and procurement, including a first trial of special flushing procedures to reduce bile duct injury, a study estimating acquired blood borne virus infections in donated organs (Australia), utilization and outcomes from normothermic regional perfusion programs using DCD organs, and the role of center-specific factors play into use of COVID+ organs. Also related to the recent COVID outbreak, spread of community-acquired respiratory infections in lung transplant recipients is examined. Not to be left out, an article on busulfan or treosulfan conditioning in older patients is available for our hematopoietic stem cell transplant experts. Many facet of transplantation medicine are covered in this Transplantation Direct issue – please visit our open access site for further details.