The Transplantation Direct June issue is now available online. Organ donation continues to be a hot topic, with a report from a large OPO regarding a systematic approach to decrease donor kidney non-use. Also in kidney transplantation, studies are presented on the highly predictive value of walking ability and brain natriuretic peptide for waitlist removal and serum creatinine (versus biopsy) for predicting antibody-mediated rejection, as well as studies on using antibodies to mask MHC I antigens during ex vivo organ perfusion (pig) in alloimmunized recipients, and key differences regarding presentation and workup of cases of lithiasis versus encrusted pyelitis. In liver transplantation, we have articles on markers distinguishing primary nonfunction from early graft dysfunction, characterization of outcomes and complications with steroid use, and experiences with pure laparoscopic donor right hepatectomy from an experienced Southeast Asian Center. For our lung transplant readership, the use of tixagevimab-cilgavimab in COVID-19+ transplant recipients with breakthrough infections is evaluated, relative versus absolute changes in donor-derived cell-free DNA is compared for diagnosis of acute allograft dysfunction, and a case of postmortem vascular Ehlers Danlos syndrome is reported. In islet transplantation, there is an analysis of cognitive outcomes in recipients. Experimentally, we have an article on the potential role of extracellular vesicle-associated GARP/TGF:LAP production as a mechanism immune tolerance. For further details on all these studies, please visit the Transplantation Direct open-access website!