Transplantation Direct - July 2023 Issue

Just Released - Transplantation Direct - July 2023 Issue

We are pleased to announce that Transplantation Direct has received its first Impact Factor of 2.3. As a relative newcomer journal in the field, this is a very encouraging initial evaluation that we will continue to build on, and a milestone step forward for the journal.

Our July issue has a broad spectrum of content, including reports in kidney transplantation on the need for follow-up biopsies in cases of TCMR and on first evidence of endocrine activity in normothermic machine perfusion kidneys; in addition, there are case reports on Birt-Hogg-Dubé syndrome with renal cell carcinoma in a living donor transplant and the use of checkpoint inhibitor therapy in a recipient with upper tract urothelial carcinoma. In liver transplantation, a study on important characteristics of new-onset systolic heart failure is presented. There are several reports in lung transplantation, including an assessment of whether ECMO bridging to transplantation increases HLA sensitization, the use of CMV immunity testing to predict viremia, a trial that evaluated safety of transplanting HCV-RNA+ lungs, a study looking at whether DQA1 eplet mismatch load can predict CLAD, and introduction of a multimodal education plan to reduce skin cancer in lung transplant recipients. We have an article in pancreas transplantation on outcomes regarding surgical site infections after peri-operative prophylaxis with enterococcus coverage. On the topic of organ donation, a Canadian group reports on sociodemographic variables at play in their organ donation organizations. For complete details on all these articles, please visit our open access Transplantation Direct website.

Table of Contents

Letter to the Editor

Kidney Transplantation

Liver Transplantation

Lung Transplantation

Pancreas and Islet Transplantation

Organ Donation and Procurement

News Spotlight

Lessons learned from first genetically-modified pig heart into human patient

A new study published in The Lancet has revealed the most extensive analysis to date on what led to the eventual heart failure in the world's first successful transplant of a genetically-modified pig heart into a human patient. This groundbreaking procedure was conducted by University of Maryland School of Medicine (UMSOM) physician-scientists back in January 2022 and marked an important milestone for medical science.

Kidney transplant recipients may benefit from new fluid therapy

July 6 - The Lancet - A major clinical trial authored by many TTS members was published in The Lancet. This study has found a simple change to world practice for kidney transplants could deliver real benefits for recipients and reduce their need for dialysis by 25 per cent. This group also published a paper in our Transplantation Direct in December 2022.

Transplantation Highlighted Articles

Transplantation - Highlighted Tweets

Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion
End-ischemic ex situ normothermic machine perfusion (NMP) enables assessment of donor livers prior to transplantation. The objective of this study was to provide support for bile composition as a marker of biliary viability and to investigate whether bile ducts of high-risk human donor livers already undergo repair during NMP.
Imlifidase Desensitization in HLA-incompatible Kidney Transplantation: Finding the Sweet Spot
Imlifidase, derived from a Streptococcus pyogenes enzyme, cleaves the entire immunoglobulin G pool within hours after administration in fully cleaved antigen-binding and crystallizable fragments. This review discusses outcomes of preclinical and clinical studies on imlifidase and describes the phase III desensitization trials that are currently enrolling patients. A comparison is made with other desensitization methods.

Transplantation Direct - Highlighted Tweets

MHC Class I Masking to Prevent AMR in a Porcine Kidney Transplantation Model in Alloimmunized Recipients
We hypothesized that masking MHC ex vivo before transplantation could help to prevent early AMR in presensitized recipients. We evaluated a strategy of MHC I masking by an antibody during ex vivo organ perfusion in a porcine model of kidney transplantation in alloimmunized recipients.
Walking Ability and Brain Natriuretic Peptide Are Highly Predictive of Kidney Transplant Waiting List Removal
Kidney transplant waitlist management is complex because waiting time is long, and the patients have significant comorbidities. Identification of patients at highest risk for waiting list removal for death and medical complications could allow better outcomes and allocation of resources.

IPITA-IXA-CTRMS Joint Congress - Registration is Open!

Early-bird Registration Deadline: July 24
Take advantage of the reduced fees!

The International Pancreas and Islet Transplant Association (IPITA), the International Xenotransplantation Association (IXA), and the Cell Transplant and Regenerative Medicine Society (CTRMS) reaffirm their strong partnership as leaders in transplantation and promise to provide an outstanding and innovative program.

Leading experts and opinion leaders from all over the world will present the latest data and address important needs in clinical and experimental transplant therapy. Specific sessions will be devoted to hot research in whole-organ pancreas transplantation, islet transplantation, stem cell therapy, xenotransplantation and transplant biology.

We are expecting close to 600 delegates from all over the world.

We look forward to welcoming YOU to San Diego!

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