The September content of Transplantation Direct is available online. This issue covers a wide-variety of subjects in transplantation. Starting with kidney transplants, we have studies on the relationship of soluble aKlotho and intact FGF on transplant outcomes, the association of BK virus and urinary tract infections with DGF, management of cases of donor-derived EBV mucocutaneous ulcertation, and a review of sex and gender disparities in living kidney donation. Also, specific components of frailty are evaluated in kidney-pancreas and pancreas alone transplantation. In liver transplantation, lessons learned from an in-depth analysis of adverse events are provided to improve living liver donation, and practices and attitudes are examined at US transplant centers regarding early transplantation for alcohol-associated liver disease. For those interested in lung transplants, there are articles on the use of -NAD+ to reduce acute rejection, and on the use of Azithromycin prophylaxis to decrease lymphocytic bronchitis. In intestinal transplantation, we have an article examining immunosuppression practices amongst US intestinal transplant centers. Related to organ donation and procurement, a case study and literature review of donor-origin neuroendocrine cancer is presented, as well as the use of CNIs to reduce kidney ischemia-reperfusion injury. From Finland, authors there used the Finnish Transplant Registry to take a renewed look at tuberculosis in transplant recipients. We welcome you to visit our Transplantation Direct website to get complete details of these articles in open-access.