Just Released - Transplantation Journal - October Issue

This issue contains a number of important papers that you cannot afford to miss. First, the ILTS consensus guidelines created in collaboration with the iLDLT and LTSI societies provide guidelines for all aspects of Small for Size Syndrome. Second, biomarker sciences are well covered in an overview of Liver biomarkers, two brilliant articles on proteomics, one from a more technical and the other a more clinical perspective, an overview of RNA Seq approaches and an authoritative analysis of biomarkers for tolerance. Elsewhere in the issue are papers on bone mineral disorders after transplantation, liver allocation in children, frailty in lung recipients and much more.

Table of Contents

Around the World

Research Highlights

Game Changer

Special Feature

Meeting Report


News Spotlight

Girl receives UK’s first kidney transplant without need for lifelong drugs

An eight-year-old girl has been spared from taking lifelong drugs to stop her body rejecting her kidney transplant thanks to a UK-first treatment. Aditi Shankar’s immune system was “reprogrammed” after a stem cell transplant, resulting in her body accepting a donor kidney as its own, clinicians said.

Biden signs Securing the U.S. Organ Procurement Transplantation Network Act into law

As a result of the OPTN (H.R. 2544), Congress aims to increase competition and transparency in the transplant system by reforming the way the Health Resources and Services Administration (HRSA) funds and manages the network. Under the bipartisan legislation, which was passed by the U.S. House and Senate in July, HRSA can award grants, contracts or cooperative agreements to support the OPTN, while eliminating a cap on the amount of available support funding for the network. The OPTN must operate using select awards, and the Government Accountability Office must review its historical financial operations.

Second Pig-Heart Transplant Patient at UM Faring Well

The second patient to be transplanted with a genetically modified pig heart at the University of Maryland Medical Center (UMMC), Baltimore, is said to be stable and doing well after the September 22 operation. The organ passed an early test by avoiding hyperacute rejection.
Physicians for the patient, a 58-year-old former lab tech repeatedly turned down for standard allograft transplantation, say they are making good use of lessons from last year's case of David Bennett, who survived in hospital with difficulty for 2 months after receiving the first such heart at the center in January 2022.

$2.8M NIH Grant to Support Development of Kidney Transplant AI

Researchers at University of Florida (UF) Health have been awarded a $2.8 million grant from the National Institutes of Health (NIH) to develop an artificial intelligence (AI)-based clinical decision support system to help improve kidney transplant outcomes.
As part of the five-year project, the research team will examine how AI models could assist with diagnosis, prediction, and care management for kidney transplant patients. In particular, one of the tools being developed will leverage patient data and analysis of kidney tissue samples to predict transplant outcomes.

TTS-ISN Sister Centers Application Submission - DEADLINE APPROACHING!

Submission Deadline: October 15

Thanks to a partnership with The Transplantation Society (TTS), this program pairs up emerging transplant centers with established centers so they can benefit from educational support and work together to increase opportunities for kidney transplant patients in low-resource countries.

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Transplantation Journal Highlights

Transplantation - Highlighted Tweets

South Asian Transplant Infectious Disease Guidelines for Solid Organ Transplant Candidates, Recipients, and Donors
These guidelines discuss the epidemiology, screening, diagnosis, posttransplant prophylaxis, monitoring, and management of endemic infections in solid organ transplant (SOT) candidates, recipients, and donors in South Asia. The guidelines also provide recommendations for SOT recipients traveling to this region. These guidelines are based on literature review and expert opinion by transplant physicians, surgeons, and infectious diseases specialists, mostly from South Asian countries (India, Pakistan, Bangladesh, Nepal, and Sri Lanka) as well as transplant experts from other countries.
Surgical Treatment of Hepatocellular Carcinoma: Multicenter Competing-risk Analysis of Tumor-related Death Following Liver Resection and Transplantation Under an Intention-to-treat Perspective
Early-stage hepatocellular carcinoma could benefit from upfront liver resection (LR) or liver transplantation (LT), but the optimal strategy in terms of tumor-related outcomes is still debated. We compared the oncological outcomes of LR and LT for hepatocellular carcinoma, stratifying the study population into a low-, intermediate-, and high-risk class according to the risk of death at 5-y predicted by a previously developed prognostic model. The impact of tumor pathology on oncological outcomes of low- and intermediate-risk patients undergoing LR was investigated as a secondary outcome.

Transplantation Direct - Highlighted Tweet

Prolonged Survival and Preserved Renal Graft Function in a Kidney Transplant Patient With Advanced Urothelial Carcinoma Using an Immune Checkpoint Inhibitor: A Case Report
Upper tract urothelial carcinoma (UTUC) is a rare but aggressive malignancy with an incidence of 2 cases per 100 000 people. Cisplatin-based chemotherapy is the standard treatment for advanced UTUC with a very poor prognosis. The median overall survival is 6–15 mo and the 5-y survival rate is <5%. Pembrolizumab, an immune checkpoint inhibitor (ICI), has been introduced for treating advanced urothelial carcinoma (UC) in cisplatin-ineligible patients. However, to our knowledge, there is no report concerning treating advanced UTUC in kidney transplant patients (KTPs).

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