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In Case You Missed It…Recent Recordings


Transplantation Journal Highlights

Transplantation - Social Media Content

Guidelines advise eculizumab prophylaxis for most kidney transplant recipients with atypical HUS. This study is in regard to death-censored graft survival, rescue therapy is not inferior to eculizumab prophylaxis.
Kidney Transplantation in Patients With aHUS: A Comparison of Eculizumab Prophylaxis Versus Rescue Therapy
Guidelines advise eculizumab prophylaxis for most kidney transplant recipients with atypical hemolytic uremic syndrome (aHUS). However, recurrence rates may be overestimated, and starting eculizumab at relapse (“rescue therapy”) may prevent graft loss. Randomized controlled trials have not compared the efficacy, safety, and costs of different treatment strategies. We performed a comparative study, including a previously described Dutch cohort treated with rescue therapy and a UK cohort using eculizumab prophylaxis.
Well-read review on the generation, activation, and functions of the T-bet+ B-cell subset outside of allotransplantation, and the relevance of this subset as mediators of allograft injury
T-bet+ B Cells in Humans: Protective and Pathologic Functions
The humoral immune system comprises B cells and plasma cells, which play important roles in organ transplantation, ranging from the production of both protective and injurious antibodies as well as cytokines that can promote operational tolerance. Recent data from conditions outside of transplantation have identified a novel human B-cell subset that expresses the transcription factor T-bet and exerts pleiotropic functions by disease state. Here, we review the generation, activation, and functions of the T-bet+ B-cell subset outside of allotransplantation, and consider the relevance of this subset as mediators of allograft injury.

Transplantation Direct - Social Media Content

Evaluating Islet Cell Isolation and Transplantation From Donors Following Medical Assistance in Dying
Limited information is available regarding outcomes of islet cell isolation (ICI) and transplantation (ITx) using medical assistance in dying (MAiD) donors. We aimed to assess the feasibility and outcomes of ICI and ITx in MAiD donors.
Mesangial Expansion by Morphometry at 5 y After Kidney Transplantation: Incidence, Risk Factors, and Association With Graft Loss
Mesangial expansion (ME) is an understudied histologic lesion in renal allografts. The current Banff mm score is not reproducible and may miss important ME features. The study aimed to improve the quantification of ME using morphometry, assess changes over time, and determine its association with allograft loss.

In the News 

Duquesne University has received a new $1.5 million grant that will expand research into using nanoparticle technology to preserve human limbs for transplantation surgeries.

Aug. 7 - The grant awarded to Dr. Jelena M. Janjic of Duquesne’s School of Pharmacy will create novel preservation strategies for multiple tissue types, including skin, bone, nerves and blood vessels. Preserving tissue is essential for successful transplantation, as several hours can pass before the donor tissue is recovered and transplanted into the patient. As the lead researcher, Dr. Janjic will partner with Dr. Vijay S. Gorantla, professor of surgery at Atrium Health Wake Forest Baptist Medical Center, to study the efficacy of novel therapies developed in her lab at Duquesne. Faron Pharmaceuticals, a Finnish drug discovery company, and BMIOrganbank, a leader in clinical and research solutions for organ preservation, are industry collaborators on the project.

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